Formulation of a fast-disintegrating drug delivery system from cyclodextrin/naproxen inclusion complex nanofibrous films.

Naproxen is a well-known non-steroidal anti-inflammatory drug (NSAID) that suffers from limited water solubility. The inclusion complexation with cyclodextrin (CD) can eliminate this drawback and the free-standing nanofibrous film (NF) generated from these inclusion complexes (ICs) can be a promising alternative formula as an orally disintegrating drug delivery system. For this, naproxen/CD IC NFs were generated using the highly water soluble hydroxypropylated derivative of βCD (HPβCD) with two different molar ratios of 1/1 and 1/2 (drug/CD).

Atomic layer deposition of palladium nanoparticles on a functional electrospun poly-cyclodextrin nanoweb as a flexible and reusable heterogeneous nanocatalyst for the reduction of nitroaromatic compounds.

We here show a rational approach for the fabrication of a flexible, insoluble catalytic electrospun nanoweb of cross-linked cyclodextrin (CD) for the reduction of nitroaromatics. CD nanofibers were produced by electrospinning an aqueous HP-β-CD solution containing a multifunctional cross-linker (, 1,2,3,4-butanetetracarboxylic acid, BTCA) and were subsequently cross-linked by heat treatment, which led to an insoluble electrospun poly-CD nanoweb. The poly-CD nanoweb was decorated with Pd nanoparticles (Pd-NPs) by atomic layer deposition (ALD) technique over 20 cycles to give rise to a catalytic electrospun nanoweb (, Pd@poly-CD).