4,082 results match your criteria: "Corneal Graft Rejection"
Klin Monbl Augenheilkd
October 2024
Department of Ophthalmology, Saarland University Medical Centre (UKS), Homburg/Saar, Germany.
Corneal stromal opacities can severely impact visual acuity if they are located in the visual axis. Homologous penetrating keratoplasty (HPK) is usually the preferred surgical option in such clinical circumstances. However, autologous penetrating keratoplasty (APK) could be an immunologically safer alternative.
View Article and Find Full Text PDFOcul Surf
October 2024
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater StudiorumUniversity of Bologna, Bologna, Italy. Electronic address:
BMJ Open Ophthalmol
October 2024
Ophthalmology, Stanford University, Stanford, California, USA
Ophthalmologie
October 2024
Zentrum für Augenheilkunde, Universitätsklinikum Köln, Kerpenerstr. 62, 50937, Köln, Deutschland.
Background: EndoArt® (Eye Yon Medical, Ness Ziona, Israel) is a novel artificial corneal inner layer transplant and an innovative treatment alternative for patients at high risk for graft failure after posterior lamellar corneal transplantation (EK).
Aim Of The Study: We present the initial results of the EndoArt® implantation in patients with glaucoma drainage devices (GDD).
Patients And Surgical Procedure: In this study 12 eyes with GDD were retrospectively evaluated.
Am J Ophthalmol
December 2024
Department of Research & Evaluation (J.K., J.T., C.J., A.F., Y.L.), Kaiser Permanente Southern California, Pasadena, California, USA.
Cells
September 2024
Department of Immunology, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bialystok, Poland.
Despite tremendous developments in the field of laboratory testing in transplantation, the rules of eligibility for corneal transplantation still do not include typing of human leukocyte antigens (HLAs) in the donor and recipient or detection of donor-specific antibodies (DSAs) in the patient. The standard use of diagnostic algorithms is due to the cornea belonging to immunologically privileged tissues, which usually determines the success of transplantation of this tissue. A medical problem is posed by patients at high risk of transplant rejection, in whom the immune privilege of the eye is abolished and the risk of transplant failure increases.
View Article and Find Full Text PDFTransplantation
October 2024
Eye Clinic, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.
Eur J Ophthalmol
September 2024
Chief Medical Officer, Paediatric and Strabismus surgery, Aravind Eye Hospital and Post graduate Institute of Ophthalmology, Tirunelveli, India.
J Clin Med
August 2024
Laboratory of Ocular Immunology, Transplantation and Regeneration, Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
: In this study, we establish a protocol for evaluating the outcomes of endothelial keratoplasty, including graft survival, rejection, or failure. Additionally, we also evaluate the alloimmune response in graft recipients. : We performed EK using C57BL/6 (allogeneic) and BALB/c (syngeneic) as donors and BALB/c mice as recipients.
View Article and Find Full Text PDFBMC Ophthalmol
September 2024
Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), 372 Jingsi Road, Jinan, 250021, China.
Background: This study aims to evaluate the clinical outcomes and efficacy of a modified tectonic corneoscleral graft (TCG) in patients suffering from devastating corneoscleral infections.
Methods: Thirty-eight eyes from 38 patients who underwent the modified TCG were included in this study. The outcomes measured were recurrence rates, best-corrected visual acuity (BCVA), ocular surface stability, postoperative complications, and graft survival.
Mol Ther
November 2024
Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA; Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Bedrock Therapeutics, Raleigh, NC 27613, USA. Electronic address:
Corneal blindness affects more than 5 million individuals, with over 180,000 corneal transplantations (CTs) performed annually. In high-risk CTs, almost all grafts are rejected within 10 years. Here, we investigated adeno-associated virus (AAV) ex vivo gene therapy to establish immune tolerance in the corneal allograft to prevent high-risk CT rejection.
View Article and Find Full Text PDFAm J Ophthalmol
December 2024
From the Instituto de Oftalmologia Fundacion Conde de Valenciana IAP (G.O.-M., G.R.V.-D., D.J.-C., J.A.R., K.A.R., J.L.D.-H., C.A.M.-M., A.N., A.R.-M., E.O.G.-H.), Mexico City, Mexico. Electronic address:
Purpose: Describe complications, functional success, and retention of the Lucia Keratoprosthesis (KPro).
Design: Retrospective interventional case series METHODS: The demographic data, baseline characteristics, complications, functional success, and retention were analyzed for Lucia KPro at the Instituto de Oftalmologia Conde de Valenciana in Mexico City from 2021 to 2023. Multivariate regression analysis and Kaplan-Meier plots were performed to identify associations with functional failure.
Curr Eye Res
September 2024
Department of Ophthalmology, The People's Hospital of Leshan, Leshan, Sichuan Province, China.
Purpose: Dermoid excision combined with lamellar keratoplasty was one of the most common surgical techniques for corneal dermoid. Due to the huge shortage of corneal donors, small incision lenticule extraction (SMILE) derived lenticules might be the novel and feasible corneal grafts instead of traditional corneal donors. Therefore, we tried to use FG boned multi-layer lenticules as grafts in the treatment of corneal dermoid.
View Article and Find Full Text PDFCarbohydr Polym
November 2024
College of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610065, China. Electronic address:
J Pers Med
July 2024
Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
Biomater Sci
September 2024
Department of Complex Tissue Regeneration, Maastricht University, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht, the Netherlands.
Corneal diseases, a leading cause of global vision impairment, present challenges in treatment due to corneal tissue donor scarcity and transplant rejection. Hydrogel biomaterials in the form of corneal implants for tissue regeneration, while promising, have faced obstacles related to cellular and tissue integration. This study develops and investigates the potential of granular polyrotaxane (GPR) hydrogels as a scaffold for corneal keratocyte growth and transparent tissue generation.
View Article and Find Full Text PDFEur J Hum Genet
December 2024
UCL Institute of Ophthalmology, University College London, London, UK.
Corneal dystrophies are phenotypically and genetically heterogeneous, often resulting in visual impairment caused by corneal opacification. We investigated the genetic cause of an autosomal dominant corneal stromal dystrophy in a pedigree with eight affected individuals in three generations. Affected individuals had diffuse central stromal opacity, with reduced visual acuity in older family members.
View Article and Find Full Text PDFInt J Ophthalmol
August 2024
Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250021, Shandong Province, China.
Aim: To describe the surgical procedure of fusiform penetrating keratoplasty (FPK) using multiple trephines of different sizes for treating patients with severe infectious keratitis.
Methods: Fourteen eyes underwent FPK, and 15 eyes received conventional penetrating keratoplasty (PK) were included in the study. The best-corrected visual acuity (BCVA), refractive outcomes, endothelial cell density, and postoperative complications were recorded.
J Clin Med
July 2024
Department of Ophthalmology, University Hospital of Cologne, 50937 Cologne, Germany.
Corneal inflammatory hem- and lymphangiogenesis significantly increase the risk for immune rejection after subsequent allogeneic corneal transplantation. The purpose of this study was to analyze the impact of temporary selective inhibition of lymphangiogenesis after transplantation on graft survival. Allogeneic transplantation from C57BL/6 mice to BalbC mice was performed as "high-risk" keratoplasty in a prevascularized corneal host bed (suture-induced inflammatory corneal neovascularization).
View Article and Find Full Text PDFSurv Ophthalmol
August 2024
Department of Ophthalmology, Campus Bio-Medico University, Rome, 00128, Italy; Cornea Rare Diseases Center, Fondazione Policlinico Campus Bio-Medico, Rome, 00128, Italy. Electronic address:
Jpn J Ophthalmol
September 2024
Department of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Itabashi, Tokyo, Japan.
Endothelial transplantation has recently been accepted worldwide, in the long history of corneal transplantation. The introduction of endothelial keratoplasty (Descemet stripping automated endothelial keratoplasty and Descemet membrane endothelial keratoplasty) has enabled us to expand the surgical indications owing to the low incidence of rejection and quick recovery of visual function. New technologies have been developed to ensure stable postoperative outcomes with a shorter learning curve, such as transplantation using cultured human endothelial cells and induced pluripotent stem cells (iPS) or new devices such as artificial endothelium.
View Article and Find Full Text PDFJ Immunother
January 2025
UT Southwestern Medical Center, Internal Medicine, Dallas, TX.
We report the case of corneal transplant rejection in a 77-year-old male receiving durvalumab as consolidative therapy for stage IIIB non-small cell lung cancer (NSCLC). Following successful chemoradiation and initiation of durvalumab, the patient underwent a right corneal transplant for corneal dystrophy. Six months after an initially stable post-transplant course, he developed progressive visual decline culminating in graft failure 1 year later despite treatment with prednisone eye drops.
View Article and Find Full Text PDFACS Nano
July 2024
Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
High-risk (HR) corneal transplantation presents a formidable challenge, with over 50% of grafts experiencing rejection despite intensive postoperative care involving frequent topical eyedrop administration up to every 2 h, gradually tapering over 6-12 months, and ongoing maintenance dosing. While clinical evidence underscores the potential benefits of inhibiting postoperative angiogenesis, effective antiangiogenesis therapy remains elusive in this context. Here, we engineered controlled-release nanomedicine formulations comprising immunosuppressants (nanoparticles) and antiangiogenesis drugs (nanowafer) and demonstrated that these formulations can prevent HR corneal transplantation rejection for at least 6 months in a clinically relevant rat model.
View Article and Find Full Text PDF