4,082 results match your criteria: "Corneal Graft Rejection"
Surv Ophthalmol
December 2024
Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Systematic review and meta-analysis We assessed the efficacy of deep anterior lamellar keratoplasty (DALK) and penetrating (PK) for macular corneal dystrophy (MCD) We searched on 4 databases for articles published up to the end of April 2024. The study's outcome was postoperative visual acuity and other factors that may affect visual outcomes (e.g.
View Article and Find Full Text PDFInt J Ophthalmol
December 2024
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, Guangdong Province, China.
Aim: To investigate the efficacy of systemic mycophenolate mofetil (MMF) as an adjunct in combination with topical tacrolimus (FK506) and corticosteroid eyedrops for preventing corneal graft rejection after high-risk keratoplasty (HRK).
Methods: In this cohort study, 55 consecutive patients (55 eyes) from an eye center who met the criteria of HRK were included. The definition for HRK includes large grafts of no less than 9 mm diameter, vascularized cornea of two or more quadrants, regrafting, or eccentric grafts.
Int J Ophthalmol
December 2024
Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou 570311, Hainan Province, China.
Aim: To evaluate the clinical efficacy and feasibility of superficial corneal opacities treated by excimer laser phototherapeutic keratectomy (PTK) combined with small incision lenticule extraction (SMILE)-derived corneal stromal lenticule transplantation.
Methods: A retrospective interventional case series of nine patients aged 12-59y with superficial corneal opacity caused by different pathologies who underwent standardized PTK combined with SMILE-derived corneal stromal lenticule transplantation was examined. Lenticule patches were fixed with fibrin glue.
Ophthalmol Ther
December 2024
University Eye Clinic Maastricht, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.
Introduction: To investigate 5-year outcomes on intraocular pressure (IOP) and safety of micropulse transscleral cyclophotocoagulation (TSCPC) in patients with glaucoma.
Methods: Patients with mild to advanced glaucoma who underwent a standardized micropulse TSCPC procedure at the University Eye Clinic Maastricht from November 2016 to February 2019 were included.
Results: A total of 165 eyes were included, with outcomes for 112 eyes available after 5-year follow-up.
Transplantation
December 2024
Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France.
Background: Allogeneic graft rejection is the leading cause of graft failure in corneal transplantation (CT) despite the immune privilege of the anterior chamber and corneal bed. The ability to identify patients at higher risk of acute rejection before or after CT could have a major impact on the clinical management of these patients.
Methods: To address this important issue, a multicenter European cohort of low-risk (n = 142) and high-risk (n = 102) CT recipients was established, and the immune system was evaluated in detail in peripheral blood mononuclear cells and plasma before and 6 and 12 mo posttransplantation.
Br J Ophthalmol
December 2024
Department of Translational Medicine and for Romagna, University of Ferrara, Ferrara, Italy.
Background/aims: To explore the outcomes of conjunctival flap (CF) followed by keratoplasty in patients with severe infectious keratitis (IK) unresponsive to medical treatment.
Methods: This is a retrospective monocentric study including 29 eyes of 29 patients with IK resistant to antibiotic treatment associated with stromal ulcer deepening to ≥50% of corneal thickness. All eyes underwent Gundersen's CF procedure and penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK) or mushroom keratoplasty (MK), at least 4 months thereafter.
Sci Rep
November 2024
Chashmyar Company, Tehran, Iran.
Machine learning can be used to identify risk factors associated with graft rejection after corneal transplantation for keratoconus. The study included all keratoconus eyes that underwent primary corneal transplantation from 1994 to 2021. Data relating to the recipient, donor, surgery, and postoperative course that might be associated with the occurrence of a graft rejection reaction were compiled.
View Article and Find Full Text PDFOcul Surf
November 2024
Centre for Regenerative Medicine ''S. Ferrari'', University of Modena and Reggio Emilia, Modena, Italy. Electronic address:
PLoS Negl Trop Dis
November 2024
Global Neglected Tropical Diseases Programme, World Health Organization, Geneva, Switzerland.
J Curr Ophthalmol
October 2024
Department of Ophthalmology, Vall d'Hebron University Hospital, Barcelona, Spain.
Purpose: To highlight the rarity of the endothelial rejection line, also known as the Khodadoust line, as a manifestation following Descemet's stripping automated endothelial keratoplasty (DSAEK). The objective is to present a meticulously detailed case, including imaging and anterior optical coherence tomography (OCT), to enhance understanding and recognition of this phenomenon.
Methods: A detailed case presentation involving a 50-year-old male, 3 years post-DSAEK transplantation for endothelial damage resulting from intraocular surgeries.
Acta Biomater
January 2025
Laboratory of Biochemistry and Biomedical Materials, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China. Electronic address:
BMC Ophthalmol
November 2024
Department of Ophthalmology, Ministry of National Guard Health Affairs, P O BOX 22490, Riyadh, 11426, Saudi Arabia.
Background: Keratoplasty is a surgical procedure in which a damaged or diseased cornea is replaced with healthy donor tissue, thereby restoring vision. Recent advancements have led to the replacement of penetrating keratoplasty (PKP) with the more selective deep anterior lamellar keratoplasty (DALK) procedure, especially for treating keratoconus. Although DALK typically has a shorter recovery time, less pain and a lower risk of rejection, PKP is still being performed for more severe corneal diseases.
View Article and Find Full Text PDFAdv Sci (Weinh)
November 2024
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China.
Cureus
October 2024
Ophthalmology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pimpri, IND.
Background Infectious keratitis (IK) is one of the major causes of corneal blindness in developing and developed nations. Numerous infections, including bacterial, fungal, viral, and protozoa, have been linked to IK. Corneal perforations can happen as one of the complications of IK.
View Article and Find Full Text PDFSci Rep
November 2024
Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Eye Institute, Gansu Road 4, Heping District, Tianjin, 300020, China.
This study aimed to describe a novel sandwich technique of minimally invasive surgical implantation by using corneal stromal lenticules for corneal perforation. This prospective observational study included nine patients aged 23-79 years (mean, 54 ± 9) from Tianjin Eye Hospital. Corneal stromal lenticules with a central thickness of 120 μm were obtained from small incision lenticule extraction(SMILE).
View Article and Find Full Text PDFInt Ophthalmol
November 2024
Department of Ophthalmology, Ege University Faculty of Medicine, Bornova, 35100, Izmir, Turkey.
Purpose: The aim of this study is to present the results of patients who underwent emergency keratoplasty for tectonic or therapeutic reasons.
Methods: Medical records of 33 patients who underwent tectonic or therapeutic keratoplasty at Ege University Department of Ophthalmology between January 2019 and January 2024 were retrospectively evaluated. Demographic characteristics, ocular and systemic findings, indications of keratoplasty, size of grafts, need for re-keratoplasty, preoperative treatment modalities, need for additional surgical interventions, and prognosis of the patients were investigated.
Int Ophthalmol
November 2024
Department of Biostatistics, LV Prasad Eye Institute, Hyderabad, Telangana, India.
Lancet
November 2024
Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan; Premium Research Institute for Human Metaverse Medicine, Osaka University, Suita, Osaka, Japan. Electronic address:
Background: The loss of corneal epithelial stem cells from the limbus at the edge of the cornea has severe consequences for vision, with the pathological manifestations of a limbal stem-cell deficiency (LSCD) difficult to treat. Here, to the best of our knowledge, we report the world's first use of corneal epithelial cell sheets derived from human induced pluripotent stem cells (iPSCs) to treat LSCD.
Methods: This non-randomised, single-arm, clinical study involved four eyes of four patients with LSCD at the Department of Ophthalmology, Osaka University Hospital.
Front Med (Lausanne)
October 2024
Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, China.
Cornea
October 2024
Department of Ophthalmology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf; and.
Sci Rep
October 2024
Division of Ophthalmology, Department of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
The lymphatic system is a crucial contributor to allograft rejection after corneal transplantation. However, no surgical procedures for the central pathway where conjunctival lymphatic vessels converge have been investigated. Therefore, we aimed to establish a murine model of lymphatic vessel ligation and evaluate its inhibitory effect on corneal allograft rejection.
View Article and Find Full Text PDFCureus
September 2024
Department of Ophthalmology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, IND.
Aim: The aim of the study was to determine any new findings provided by anterior segment optical coherence tomography (AS-OCT) in different corneal diseases diagnosed by slit lamp examination (SLE).
Methods: This cross-sectional, observational, hospital-based study was conducted at a tertiary care centre in Western Maharashtra from September 2022 to June 2024, and it included 93 eyes of 93 patients with isolated corneal diseases. A detailed SLE of the anterior segment was done to assess corneal pathology, corneal thickness, corneal structural integrity, presence of corneal opacities, corneal vascularization, presence of other abnormalities like corneal degeneration, corneal foreign bodies, Kayser-Fleischer (KF) ring, ocular surface squamous neoplasia (OSSN).
Ocul Surf
October 2024
Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Labbafinejad Medical Center, Department of Ophthalmology, Cornea & Ocular Surface Service, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Severe limbal stem cell deficiency (LSCD) resulting from chronic and delayed-onset mustard gas keratopathy (MGK) presents substantial management challenges. This article introduces an "en bloc" surgical procedure combining a 270-degree keratolimbal allograft (KLAL) with central lamellar keratoplasty (CLK) as a novel approach to treat this condition.
Methods: A retrospective case series was conducted at Labbafinejad Medical Center in Tehran, Iran, from 2002 to 2019, including 13 eyes from 13 male patients diagnosed with chronic and delayed-onset MGK.
Ann Transplant
October 2024
Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
BACKGROUND Penetrating keratoplasty (PK) remains the most common corneal transplant method in China. In this paper we aim to analyze the outcomes and the potential factors associated with graft failures of PKs in one of the largest keratoplasty centers in Eastern China during the past 4 years. MATERIAL AND METHODS A retrospective review was performed on 502 eyes from 481 recipients undergoing PKs from January 2018 to December 2021 at the Eye and ENT Hospital of Fudan University.
View Article and Find Full Text PDFMol Ther
November 2024
Institute for Neurosciences of Montpellier, University Montpellier, INSERM, Montpellier, France; Department of Ophthalmology, Gui de Chauliac Hospital, Montpellier, France. Electronic address: