23 results match your criteria: "Copernicus Memorial Hospital in Lodz Comprehensive Cancer Center and Traumatology[Affiliation]"

Recovered water - HO from the F[FDG] production as liquid radioactive waste.

Appl Radiat Isot

January 2025

Department of Medical Physics, Copernicus Memorial Hospital in Lodz Comprehensive Cancer Center and Traumatology, Lodz, Poland; Department of Medical Imaging Technology, Medical University of Lodz, Ul. Lindleya 6, 90-131, Łódź, Poland.

In this study, ten recovered water samples were analysed using gamma spectrometry and Liquid Scintillation Counting techniques for identification of radioactive impurities (quality and quantity) and for radioactive waste qualifications. The presence of several radioactive isotopes of H, Co Mn in the recovered [O] water irradiated with 11 MeV protons used to produce [F] fluoride by the O(p,n)F reaction has been confirmed. Radioactive impurities were generated directly in enriched water or washed out from activated Havar foil, or tantalum body target material.

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Background: The current standard of care (SoC) for patients with extensive-disease small-cell lung cancer (ED-SCLC) is chemo-immunotherapy. The efficacy of radiotherapy (RT) for chest consolidation has been established for patients with ED-SCLC who have responded to chemotherapy. There is a lack of data on incorporating RT as chest consolidation and metastasis-directed therapy for ED-SCLC.

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Article Synopsis
  • - Gliomas are a leading cause of cancer deaths in young individuals, and there's uncertainty about the effectiveness of current treatments for certain types (WHO G2/G3) even after genetic factors like IDH1/2 mutations are considered.
  • - The study focused on the miR-200 family of microRNAs, known to regulate many important genes, to identify their relationship with clinical factors and their potential to predict outcomes in glioma patients.
  • - Results indicated that specific miR-200 family members could serve as independent survival predictors, suggesting that their expression levels could help optimize future treatment strategies for glioma patients.
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Introduction: Surgical resection is gold standard for treatment of liver metastasis, locally ablative techniques including computer tomography (CT)-guided interstitial high-dose-rate (HDR) brachytherapy (CT-BRT) and stereotactic body radiotherapy (SBRT) have gained prominence as alternatives, offering comparable outcomes in selected patients. We aim to compare CT-BRT and SBRT - based on dosimetric analysis.

Material And Methods: Patients who underwent CT-BRT for oligometastatic, ≤4cm liver metastases between 2018 and 2024 were eligible.

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Objectives: Vascular and interventional radiology procedures are characterized by high exposure of personnel to ionizing radiation. This study assessed the exposure of medical personnel to ionizing radiation during vascular radiology and mechanical thrombectomy procedures.

Material And Methods: During vascular radiology procedures, the exposure of 4 groups of workers participating in the procedures was analyzed, i.

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Bone metastases (BMs) are the most common cause of cancer-related pain and radiation therapy plays a key role in treating pain caused by it. The half-body irradiation (HBI) is a modality that can be used to treat patients with multiple painful BMs. In the modern era, concerns about toxicity and the availability of new agents requiring robust bone marrow function have limited the use of HBI in advanced cancer.

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Introduction: Radiation induced lymphopenia (RIL) deteriorate survival and diminishes the benefit of immune checkpoint inhibitors in combined treatment of lung cancer. Given the inconsistent data across various studies on the predictors of RIL, we aim to methodically elucidate these predictors and formulate a practical guide for clinicians.

Methods: We conducted observational cohort study in four tertiary cancer centers.

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Article Synopsis
  • Breast conserving treatment usually includes surgery to remove tumors followed by radiotherapy, but accurately identifying the tumor bed can result in unnecessary radiation to healthy tissue. Preoperative stereotactic body radiotherapy (SBRT) aims to target the tumor more precisely.
  • A systematic review was conducted analyzing ten clinical trials involving 188 patients, focusing on early toxicity and cosmetic results of SBRT, with median follow-up of 15 months. Treatments varied in radiation doses and fractionation methods.
  • Findings showed low rates of acute and late toxicity and excellent cosmetic outcomes for most patients. Pathological complete response rates improved with longer intervals between SBRT and surgery and when combined with other therapies, suggesting SBRT’s potential to
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Analysis of ionizing radiation doses received by patients during electrocardiological procedures.

Ir J Med Sci

October 2024

Department of Medical Imaging Technology, Faculty of Medicine, Medical University of Lodz, Lindleya 6, 90-131, Lodz, Poland.

Medical procedures in the field of electrocardiology belong to a large group of cardiological procedures. Performing them involves exposure to ionizing radiation. In this study, five medical procedures in the field of electrocardiology performed in three medical facilities were analyzed in terms of patients' exposure to ionizing radiation.

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Quality control in mammography is a very important element. One of the parameters indicating the appropriate image quality is the threshold image contrast. The CDMAM phantom is used to measure this parameter.

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During the production of F, as a result of the interaction of the beam of protons and secondary neutrons with the structural elements of the target body, many radionuclide impurities are created in the cyclotron. As part of this work, we theoretically predicted which isotopes would be activated in the target tantalum or silver bodies. Subsequently, we used gamma spectrometry analysis to verify these predictions.

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Inflammation-related mRNA expression in patients with multiple myeloma undergoing hematopoietic stem cell mobilization.

Exp Hematol

June 2023

Department of Hematology and Transplantology, Copernicus Memorial Hospital in Lodz Comprehensive Cancer Center and Traumatology, Poland; Department of Hematology, Medical University of Lodz, Poland.

Mobilization of CD34+ cells is a key element in the therapy of patients with multiple myeloma (MM) undergoing autologous stem cell transplantation. The use of chemotherapy and the granulocyte colony-stimulating factor can significantly affect the expression of inflammation-related proteins and the migration of hematopoietic stem cells. We assessed the mRNA expression of selected proteins involved in the inflammatory landscape in patients with MM (n = 71).

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High-dose chemotherapy with autologous stem-cell transplantation (ASCT) remains the standard of care in multiple myeloma (MM) patients. This retrospective study aimed to assess the impact of neutrophil-to-lymphocyte ratio (NLR) and other complete blood count (CBC)-based predictors on PFS and OS of transplant-eligible MM patients. The CBC-based biomarkers were evaluated in a single-center cohort of 176 MM patients at three time points: at the diagnosis, the time of ASCT, and +100 d after ASCT.

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Sirtuins are involved in the fate of hematopoietic stem cells (HSCs), including their metabolism, stress response, differentiation, migration, and apoptosis. The aim of this study was to explore SIRT1-7 expression during HSC mobilization. The study included 50 patients with lymphoproliferative disorders (39 multiple myeloma, 11 lymphoma).

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Salvage autologous hematopoietic stem cell transplantation (auto-HSCT) constitutes a therapeutic option for a group of well-selected patients with relapsed multiple myeloma (MM). However, if an insufficient number of stem cells were harvested and stored before the first auto-HSCT, stem cells need to be remobilized. Patients diagnosed with MM who following relapse after auto-HSCT, had remobilization and afterward, auto-HSCT with remobilized cells were included in this retrospective analysis.

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microRNAs play an important role in the regulation of gene expression, cell fate, hematopoiesis, and may influence the efficacy of CD34+ cell mobilization. The present study examines the role of hsa-miR-15a-5p, hsa-miR-16-5p, hsa-miR-34a-5p, hsa-miR-126-3p, hsa-miR-146a-5p, hsa-miR-155-5p, and hsa-miR-223-3p in the course of hematopoietic stem cell mobilization. The numbers of CD34+ cells collected in patients with hematological malignancies (39 multiple myelomas, 11 lymphomas) were determined during mobilization for an autologous hematopoietic stem cell transplantation.

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Background: Salvage autologous hematopoietic stem cell transplantation (autoHSCT) may be used to treat relapse of multiple myeloma occurring after previous autoHSCT. When insufficient number of hematopoietic stem cells was stored from the initial harvest, remobilization of stem cells is necessary.

Purpose: The analysis of stem cell remobilization after previous autoHSCT.

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Article Synopsis
  • Researchers studied the levels of ficolins and mannose-binding lectin (MBL) in 157 patients with acute myeloid leukaemia (AML) compared to 267 healthy individuals.
  • They found that ficolin-1 was significantly lower in AML patients, while ficolin-2, ficolin-3, and MBL were higher, with the highest MBL levels linked to a greater risk of severe infections.
  • Genotyping suggested a specific genetic variant (G/G homozygosity) associated with the disease, and ficolins could serve as potential new biomarkers for diagnosing AML and distinguishing it from other blood cancers.
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This paper aims to determine the levels of exposure to neutron and photon radiation among the personnel engaged in cyclotron operation and the personnel engaged in the production of radiopharmaceuticals, with the use of the environmental radiation monitoring system (RMS) installed in the positron emission tomography laboratory. The annual exposures of employees operating the cyclotron measured with the use of the RMS system are: 1.39 ± 0.

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The photo-transferred thermoluminescence phenomenon in case of emergency dose assessment.

Radiat Environ Biophys

May 2020

Faculty of Biomedical Sciences and Postgraduate Training, Department of Medical Imaging Technology, Medical University of Lodz, Lindleya 6, 90-131, Lodz, Poland.

A major disadvantage of dose reconstruction by means of thermoluminescence (TL) is the fact that during readout of any TL material exposed to ionizing radiation (i.e., during measuring the glow curve), the radiation-induced signal gets lost.

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THE STRUCTURE OF Hp(0.07) VALUES OBTAINED BY THE NUCLEAR MEDICINE PERSONNEL DURING 18F-FDG PRODUCTION AND INJECTION.

Radiat Prot Dosimetry

August 2019

Department of Medical Imaging Technology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Lindleya 6, Lodz, Poland.

The production of 18F-FDG is a multi-stage process, which includes not only obtaining the marker and labelling the radiopharmaceutical but also carrying out the quality control of the obtained compound. The staff can be exposed to ionizing radiation at any stage of production. This article presents the results of hands exposure of staff members employed in a facility, where 18F-FDG is produced and injected into patients.

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Article Synopsis
  • - This study involved 312 patients with multiple myeloma and lymphomas undergoing high-dose chemotherapy and autologous stem cell transplantation, examining the role of certain gene polymorphisms and serum concentrations of immune-related proteins.
  • - Findings indicated that multiple myeloma patients had a higher prevalence of MBL deficiency genotypes, but this was not linked to hospital infections or recovery of white blood cells, although it correlated with more severe infections during follow-up.
  • - Interestingly, high levels of MBL were associated with prolonged fever and some infections post-chemotherapy, while a notable association between a gene mutation and lymphoma was identified, and overall, the influence of MBL on infections in these patients remains conflicting.
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Objectives: Mechanical thrombectomy (MT) is not reimbursed by the Polish public health system. We present a description of 5 years of experience with MT in acute stroke in Comprehensive Stroke Centers (CSCs) in Poland.

Methods And Results: We retrospectively analyzed the results of a structured questionnaire from 23 out of 25 identified CSCs and 22 data sets that include 61 clinical, radiological and outcome measures.

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