Prognostic thresholds of fluorine-18 fluorodeoxyglucose-positron emission tomography mean and maximum standardized uptake values for survival and nodal involvement in lung neuroendocrine neoplasms.

Objectives: The mean standardized uptake value (SUVmean) and maximum standardized uptake value (SUVmax) on fluorine-18 fluorodeoxyglucose-positron emission tomography are prognostic biomarkers for survival and nodal involvement in non-small-cell lung cancer but their prognostic value in lung neuroendocrine neoplasms (NENs) remains unexplored. In this study, we aimed to examine whether they are also prognostic biomarkers for survival and nodal involvement in lung NENs.

Methods: We retrospectively studied patients with typical carcinoid, atypical carcinoid or large cell neuroendocrine carcinoma who had been radically resected at our institution between 2008 and 2020.

Implementation of an Innovative Technology Called the OR Black Box: A Feasibility Study.

. The operating room (OR) Black Box is an innovative technology that captures and compiles extensive real-time data from the OR, allowing identification and analysis of factors that influence intraoperative procedures and performances - ultimately improving patient safety. Implementation of this kind of technology is still an emerging research area and prone to face challenges.

Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention.

Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel).

Test-retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers.

Background: Myocardial flow reserve (MFR) assessment with cardiac positron emission computed tomography (PET/CT) is well established, and quantification relies on commercial software packages. However, for reliable use, repeatability and reproducibility are important. The aim of this study was therefore to investigate and compare between scans and software packages the repeatability and reproducibility of Rb-PET/CT estimated MFR.

Reproducibility of LVEF, LV volumes, and LV mass between Rubidium-82 PET/CT scans in young healthy volunteers using two commercially available software packages.

Background: Global functional parameters are available from electrocardiographic gated Rubidium-82 positron emission tomography/computed tomography (Rb-PET/CT). However, the reproducibility of these data is not clarified. We aimed to investigate reproducibility of left ventricular ejection fraction (LVEF), endsystolic volume (ESV), enddiastolic volume (EDV), and left ventricular (LV) mass between two scans and between two commercially available software packages.

Platelet count kinetics following interruption of antiretroviral treatment.

Objectives: To investigate the mechanisms of platelet kinetics in the Strategies for Management of Antiretroviral Therapy (SMART) study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) drug conservation compared with continuous treatment viral suppression. Follow-up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART.

Design: SMART patients from sites that determined platelets routinely.

Development of vaccines against Plasmodium falciparum malaria: taking lessons from naturally acquired protective immunity.

The acquisition of substantial anti-malarial protection in people naturally exposed to P. falciparum is often cited as evidence that malaria vaccines can be developed, but is rarely used to guide the development. We are pursuing the development of vaccines based on antigens and immune responses that appear key in naturally acquired protection.