1 results match your criteria: "Coordinating Centers for Disease Control and Prevention[Affiliation]"
Antigenic drift in the evolution of H1N1 influenza A viruses resulting from deletion of a single amino acid in the haemagglutinin gene.
J Gen Virol
December 2007
Influenza Division, Coordinating Centers for Disease Control and Prevention, Atlanta, GA, USA.
Article Synopsis
- Two distinct lineages of H1N1 influenza A viruses were antigenically similar until 1994, when new variants with significant antigenic differences emerged in China.
- The deletion of the amino acid K at position 134 in these new variants, like A/Beijing/262/95, provided a selective advantage, leading to the dominance of the Chinese deletion lineage.
- Research using reverse genetics confirmed that this specific K134 deletion was mainly responsible for the antigenic changes, highlighting the importance of a compatible neuraminidase surface protein for effective viral growth.