Identification of senescence rejuvenation mechanism of extract including honokiol as a core ingredient.

Reactive oxygen species (ROS) contribute to aging by mainly damaging cellular organelles and DNA. Although strategies to reduce ROS production have been proposed as important components of anti-aging therapy, effective mechanisms to lower ROS levels have not yet been identified. Here, we screened natural compounds frequently used as cosmetic ingredients to find substances that reduce ROS levels.

In the battle of survival: transcriptome analysis of hypopharyngeal gland of the Apis mellifera under temperature-stress.

Background: Temperature is one of the essential abiotic factors required for honey bee survival and pollination. Apart from its role as a major contributor to colony collapse disorder (CCD), it also affects honey bee physiology and behavior. Temperature-stress induces differential expression of genes related to protein synthesis and metabolic regulation, correlating with impaired gland function.

Sub-lethal exposure to 2,4-Dichlorophenoxyacetic acid disrupts nursing and foraging behaviors in honey bees.

A popular herbicide from the chlorophenoxy group, 2,4-Dichlorophenoxyacetic acid (2,4-D) effectively controls broadleaf weeds in agricultural environments. However, its application threatens honey bee habitats and has been implicated in colony collapse disorder (CCD) due to its toxic effects. While the general hazards of 2,4-D to honey bees are recognized, its specific impact on nursing and foraging behaviors remains poorly understood.

Synergistic ROS Reduction Through the Co-Inhibition of BRAF and p38 MAPK Ameliorates Senescence.

Reactive oxygen species (ROS)-mediated damage to macromolecules and cellular organelles is one of the major causes of senescence. Therapeutic strategies that lower ROS levels have been proposed as important treatments for senescence, but effective mechanisms for reducing ROS levels have not been discovered. Here, we aimed to find a combination that has a synergistic effect on ROS reduction using senomorphics known to reduce ROS.

Comprehensive analysis of primary and secondary metabolites and antioxidant activities provides insights into metabolic profiling of different organs of Pimpinella brachycarpa Nakai.

Pimpinella brachycarpa Nakai is a perennial plant that has been widely used as a traditional medicine. However, the comprehensive analysis of primary and secondary metabolites and antioxidant activities in different organs (flowers, leaves, stems, and roots) has not been extensively studied. A comprehensive analysis using GC-qMS, GC-TOFMS, and HPLC metabolomic analyses identified 66 known metabolites in different organs of P.

The effect of seasonal temperatures on the physiology of the overwintered honey bee.

Honey bee physiology follows an annual cycle, with winter bees living ten times longer than summer bees. Their transition can be disrupted by climate change. Several climate factors, mainly temperature, may contribute to the global losses of winter bees.

Review of the genus Rhagoba Moore, 1888 (Lepidoptera, Crambidae, Spilomelinae) from Laos, with a description of new species.

The genus Rhagoba from Laos is revised, with three species, R. octomaculalis (Moore, 1867), R. obvellata Du & Li, 2012, and R.

First report of the family Attevidae (Lepidoptera, Yponomeutoidea) from Cambodia, with description of a new species.

In the present study, we report a pantropical family Attevidae of the superfamily Yponomeutoidea in Cambodia for the first time. A new species, Atteva chalco sp. nov.

Description of Diduga siamensis sp. nov. and newly recorded D. scalprata (Lepidoptera, Erebidae, Arctiinae) from Thailand, with a checklist of the genus Diduga.

In this study, 11 species of the genus Diduga Moore, [1887] are recognized from Thailand, including a new species, Diduga siamensis Bayarsaikhan & Heppner sp. nov., and one newly recorded species, D.

Senescence Rejuvenation through Reduction in Mitochondrial Reactive Oxygen Species Generation by Extract: In Vitro Evidence.

Oxidative stress caused by reactive oxygen species (ROS) is one of the major causes of senescence. Strategies to reduce ROS are known to be important factors in reversing senescence, but effective strategies have not been found. In this study, we screened substances commonly used as cosmetic additives to find substances with antioxidant effects.

Identification of Cellular Isoschaftoside-Mediated Anti-Senescence Mechanism in and .

As cellular senescence, reactive oxygen species (ROS) accumulate excessively, causing cellular damage. Flavonoids derived from natural products are known for their antioxidant effects and their ability to delay cellular senescence. Previous studies have attempted to mitigate cellular senescence using flavonoids from natural sources.

The Improving Effects of Probiotic-Added Pollen Substitute Diets on the Gut Microbiota and Individual Health of Honey Bee ( L.).

Honey bee ( L.) health is crucial for honey bee products and effective pollination, and it is closely associated with gut bacteria. Various factors such as reduced habitat, temperature, disease, and diet affect the health of honey bees by disturbing the homeostasis of the gut microbiota.

Efficacy assessment of miltefosine and curcumin against infection.

Praziquantel (PZQ) is currently the only approved drug for treating clonorchiasis, but its poor efficacy against larvae has highlighted the need to develop newer drugs. In this study, to address this challenge, we investigated the anti-parasitic efficacy of miltefosine (MLT), curcumin (CUR), and PZQ against metacercariae (CsMC), newly excysted juvenile worms (CsNEJs), and adults. Larvicidal effects of MLT and CUR surpassed those elicited by PZQ .

Enhancing Honey Bee Health: Evaluating Pollen Substitute Diets in Field and Cage Experiments.

Honey bees ( L.) play vital roles as agricultural pollinators and honey producers. However, global colony losses are increasing due to multiple stressors, including malnutrition.

The Effects of Artificial Diets on the Expression of Molecular Marker Genes Related to Honey Bee Health.

Honey bees are commonly used to study metabolic processes, yet the molecular mechanisms underlying nutrient transformation, particularly proteins and their effects on development, health, and diseases, still evoke varying opinions among researchers. To address this gap, we investigated the digestibility and transformation of water-soluble proteins from four artificial diets in long-lived honey bee populations (), alongside their impact on metabolism and DWV relative expression ratio, using transcriptomic and protein quantification methods. Diet 2, characterized by its high protein content and digestibility, was selected for further analysis from the other studied diets.

Geographical Characteristics of and Microbiomes in Korea.

Mosquitoes, the primary vectors of arboviruses, harbor a diverse microbiome that plays a crucial role in their development, immunity, and vector competence. The composition of the mosquito microbiome is heavily influenced by the environment and habitats. Therefore, identifying the relationship between the habitat and the mosquito's microbial community can improve the overall understanding of mosquito biology.

Three new species of Cirrothaumatia Razowski & Becker from Peru, with notes on the genus (Lepidoptera: Tortricidae: Tortricinae: Cochylini).

Three new species of the cochyline genus Cirrothaumatia Razowski & Becker, 1986 are described and illustrated from submontane Andean sites in Peru (Depts. Amazonas, Junn, and San Martn): C. pichita n.