Access and knowledge of contraceptives and unmet need for family planning in Pakistan.

Background: Family planning facilities provide an extensive choice of assistance that is beneficial for women and the society. It may limit the fatality risk for mothers and babies by reducing the rate of pregnancies and abortions. The Government of Pakistan has been continuously trying to persuade the people about the importance of family planning.

COVID-19 Diagnosis within 6 Weeks of Arthroscopic Knee Surgery Leads to Higher Risk for Post-operative Venous Thromboembolism.

Purpose: To determine if pre-operative infection with COVID-19 increased risk for post-operative venous thromboembolism (VTE) in patients undergoing arthroscopic knee surgery..

Methods: PearlDiver Mariner 165 database was queried for patients undergoing knee arthroscopy between 2010 through October, 2022.

Unanswered Questions from Abortion Seekers: An application of the Research Prioritization by the Affected Community (RPAC) protocol in the Central Valley, California.

Objectives: Despite protections offered in California, there is limited understanding of abortion access in underserved regions, including the Central Valley. Furthermore, there has been limited community involvement, especially from those directly affected, in the development of research priorities in abortion care. We utilized the Research Prioritization of Affected Communities (RPAC) protocol to identify research priority topics and research questions for future abortion-related research.

Impact of progestin type on the risk of drug interactions between combined oral contraceptives and psychotropic drugs: a pooled analysis of real-world data.

Objective: To assess the risk of contraceptive failure and adverse events (AEs) associated with the type of progestin when co-administered with psychotropic drugs within a routine clinical practice setting.

Study Design: A pooled analysis of four large, prospective, multinational cohort studies including women with a new prescription of combined oral contraceptives (COCs) and concomitant psychotropic drug use from 13 European countries and the United States. We determined the frequency of contraceptive failures and AEs within six months after COC initiation by progestin type.

Non-daily contraception: Reinforcing the choice of users and addressing unmet needs of reproductive health.

Despite great societal efforts promoting female autonomy, Sweden still faces unmet contraceptive needs, with abortion rates being the highest in the Nordic countries. In this commentary, we discuss using non-daily contraception options to combat these unmet needs. Non-daily methods include transdermal (i.

Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.

Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates both oxidative stress and mitochondrial biogenesis. Our previous study reported the cardioprotection of calycosin against triptolide toxicity through promoting mitochondrial biogenesis by activating nuclear respiratory factor 1 (NRF1), a coregulatory effect contributed by Nrf2 was not fully elucidated. This work aimed at investigating the involvement of Nrf2 in mitochondrial protection and elucidating Nrf2/NRF1 signaling crosstalk on amplifying the detoxification of calycosin.

Accelerating Progress in Women's Sexual and Reproductive Health and Rights Decision-Making: Trends in 32 Low- and Middle-Income Countries and Future Perspectives.

Introduction: In 1994, the International Conference on Population and Development (ICPD) Programme of Action established the empowerment and autonomy of women as fundamental to achieving sustainable economic and social progress. Three decades later, significant strides have been made in enhancing sexual and reproductive health and rights (SRHR). However, deep-rooted gender inequality continues to impede substantial progress for many.

Progress in reducing socioeconomic inequalities in the use of modern contraceptives in 48 focus countries as part of the FP2030 initiative between 1990 and 2020: a population-based analysis.

Background: Despite increases in modern contraception use, socioeconomic inequalities in family planning persist. In this study, we aimed to measure progress in reducing socioeconomic inequalities in modern contraceptive prevalence rate (mCPR) and demand for family planning satisfied by modern methods (mDFPS) in 48 countries as part of the Family Planning 2030 (FP2030) initiative between 1990 and 2020 for which Demographic and Health Survey data were available.

Methods: We analysed two rounds of Demographic and Health Survey data per country.

The contraceptive active ingredient levonorgestrel disrupts the physiology of Macrocyclops albidus.

Active pharmaceutical ingredients, such as levonorgestrel (LNG), continue to increase in aquatic ecosystems and are detected in environmental matrices; however, their ability to bioaccumulate and cause reproductive, developmental, and biochemical defects in benthic organisms, such as Macrocyclops albidus, is unknown. This study investigated the effects of LNG on the oxidative stress response, reproduction, and development of M. albidus.

Vacuum Induced Management of Hemorrhage Using Intrauterine Foley Catheter: A Report of Two Cases.

Hemorrhage is a common postpartum complication and, though rare, is also a recognized risk associated with abortion. While most cases can be managed with uterine evacuation and uterotonic agents, some cases require additional surgical procedures. We present two cases, one of hemorrhage following dilation and evacuation, and the other of delayed postpartum hemorrhage, where a Foley catheter was used for vacuum-induced hemorrhage control.

Common myths and misconceptions surrounding hormonal contraception.

Numerous community and professional myths and misconceptions around hormonal contraception exist, many promulgated through social media. As a result of these and other factors, people are moving away from hormonal methods and potentially exposing themselves to increased risk of unintended pregnancy. A number of key myths and misconceptions have been identified in a range of papers and here we summarise the evidence around the basis for these misunderstandings.

Contribution of the community pharmacist workforce to primary care through the lens of medicines classification: comparison of Aotearoa New Zealand and Australia.

Introduction Optimal use of the workforce in primary care is critical due to increasing complexity and demand resulting from multi-morbidity in ageing populations. Improving public access to medicines by making them available via a pharmacist without prescription can support self-care while ensuring oversight by a health professional. Aim The aim of this paper was to identify and explore key differences between New Zealand and Australia in medicines classified nationally for pharmacist-only non-prescription supply.

Adult height in girls with idiopathic central precocious puberty treated with triptorelin.

Objective: Idiopathic central precocious puberty (CPP) precipitates epiphyseal fusion of growth plates in long bones, leading to reduced adult stature. Gonadotropin-releasing hormone analogues (GnRHa) are the treatment of choice for idiopathic CPP, but their benefit on height gain is unclear. We aimed to elucidate the effects of GnRHa treatment on adult height in girls with idiopathic CPP.

Pregnancy intentions and outcomes among young married women in Nepal.

Background: Approximately 44% of Nepalese women ages 15-49, desiring to avoid pregnancy, do not use modern contraceptives, resulting in an estimated 539,000 unintended pregnancies annually.

Objectives: This study aims to investigate the association between young, newly married women's pregnancy intentions and subsequent pregnancies.

Study Design: Data were collected longitudinally from 200 recently married women ages 18-25 in Nepal.

Repeat adolescent pregnancies in Southwestern Uganda: A cross-sectional study.

Background: Pregnancy in adolescents continues to remain a significant public health challenge, with repeat pregnancies in this age group often receiving insufficient attention. In Uganda, repeat adolescent pregnancy varies between 26.1% and 55.

Association Between Emotional Intimate Partner Violence Around the Time of Pregnancy and Postpartum Contraceptive Use: Results from the Pregnancy Risk Assessment Monitoring System 2016-2021.

This study assessed the relationships between emotional intimate partner violence (IPV) before, during, and after pregnancy and postpartum contraceptive use. We used 2016-2021 Pregnancy Risk Assessment Monitoring System data from seven sites ( = 30,125). We used multivariable logistic regression to assess indicators of emotional IPV and provider counseling associated with postpartum contraceptive use.

Intention to use modern contraceptives among current nonusers of reproductive age in Uganda.

Background: Women's intention to use contraceptive methods is critical for better visualization of future needs and for making it more likely to translate into actual use. This study sought to examine the determinants of intention to use modern contraceptives among current non-users of reproductive age in Uganda.

Methods: The study used secondary data from the 2016 Uganda Demographic and Health Survey (UDHS) dataset.

Over-the-counter procured emergency contraception among undergraduate students in a public University in Ghana.

Background: Emergency Contraception (EC) is more popular among young people today, yet, there is little research on Over-the-counter procured EC among undergraduate students in African universities. This study's primary goal is to fill that gap.

Methods: This was an exploratory-cross-sequential study conducted in a public university in Ghana, using 145 purposively sampled sexually active undergraduate students.

Healthcare provider communication and current contraceptive use among transgender men and gender-diverse people: results from an online, cross-sectional survey in the United States.

Objectives: To explore whether discussing contraceptive use with a healthcare provider is associated with current contraceptive use among transgender men and gender-diverse (TMGD) individuals.

Study Design: In 2019, we conducted a cross-sectional survey among transgender men and gender-diverse adults in the United States who were assigned female or intersex at birth. We measured whether respondents had ever discussed contraception with a healthcare provider as well as current use of contraception, reasons for use, and barriers to use.

A statewide analysis of uptake of highly effective contraception offered immediately postpartum in Massachusetts, 2017 - 2021.

Objectives: Our study aims to evaluate trends in Massachusetts in provision of highly effective contraception, including contraceptive implant, intrauterine device (IUD) and permanent contraception, in the immediate postpartum (iPP) period.

Study Design: Deliveries from 2017-2021 were extracted from a Massachusetts Acute Hospital database, and the primary outcomes included permanent contraception, iPP implant, or iPP IUD provision during delivery admission. Covariates included race, ethnicity, insurance, and hospital type.

Comparison of levonorgestrel in different forms and copper intrauterine devices for emergency contraception: A systematic review and meta-analysis.

Objective: Emergency contraception serves as the only dependable method for women to prevent pregnancy following unprotected sex. Among emergency contraception methods, the copper intrauterine device provides continuous, highly effective contraception for over a decade. This study aimed to evaluate the effectiveness, safety, and side effects of the copper intrauterine device over methods containing levonorgestrel for emergency contraception.

Postpartum family planning counselling during maternity care visits in Bangladesh and its effect on contraceptive initiation.

Background: Postpartum family planning (PPFP) is an essential component of birth care that helps avert maternal and newborn health hazards by preventing short-spaced births. Many Asian and African studies found PPFP counselling during antenatal care (ANC) and postnatal care (PNC) effective in increasing PPFP uptake. Studies in Bangladesh, however, provided limited evidence of the feasibility and effectiveness of integrating PPFP in maternal health services.

Reversible suppression of hypothalamo-pituitary-adrenal axis in Addison's disease due to ethinyl oestradiol-induced increase in total cortisol.

Summary: An oral contraceptive pill (OCP)-induced increase in total cortisol lead to reversible suppression of the hypothalamic-pituitary-adrenal (HPA) axis and insulin resistance (IR) in a patient with Addison's disease. We suggest that this might influence the choice of an OCP in such patients. A 20-year-old female was diagnosed with Addison's disease (cortisol: 44 nmol/L, adrenocorticotropic hormone (ACTH): >500 pg/mL) and started on hydrocortisone (HC).

Lack of Clinically Meaningful Effect of Cariprazine on the Pharmacokinetics of a Combined Oral Contraceptive.

Introduction: Cariprazine (CAR) is a potent dopamine receptor partial agonist antipsychotic approved by the EMA and the FDA. To address the uncertainty regarding the effectiveness of hormonal contraceptives during CAR co-administration and whether a second barrier method is necessary, a drug-drug interaction study with an oral contraceptive was conducted post-approval.

Methods: The phase I, fixed-sequence multicenter study involved two periods with 24 patients with schizophrenia, aiming to evaluate the effect of CAR on the pharmacokinetics (PK) of a combined oral contraceptive (COC) containing 30 μg ethinylestradiol (EE) and 150 μg levonorgestrel (LNG).