Contact Lens Wear Alters Transcriptional Responses to in Both the Corneal Epithelium and the Bacteria.

Purpose: Healthy corneas resist colonization by virtually all microbes yet contact lens wear can predispose the cornea to sight-threatening infection with . Here, we explored how lens wear changes corneal epithelium transcriptional responses to and its impact on bacterial gene expression.

Methods: Male and female C57BL/6J mice were fitted with a contact lens on one eye for 24 h.

Corneal scar after ulcer in a young patient demanding visual restoration in a timely fashion treated with PTK + topo-guided PRK.

A 23-year-old woman was referred for low visual acuity in the left eye after a corneal ulcer associated with contact lens use 2 years previously. The patient had a history of contact lens use, reported use of antibiotic eye drops with improvement of infection, and subsequent scarring. There were no comorbidities.

Wessely-type immune ring following collagen cross-linking.

A woman in her early 20s with progressive keratoconus underwent corneal collagen cross-linking using the sub400 protocol. The central 5.5 mm of the epithelium was removed after the application of 20% alcohol.

Early Sterile Keratolysis Complication With Decellularized Porcine Corneal Inlay Implant: A Case Report and Cautionary Tale.

Purpose: To describe an early sterile keratolysis associated with a decellularized porcine corneal inlay implant for keratoconus.

Methods: This is a case report of a 23-year-old man with keratoconus who underwent lenticular intrastromal keratoplasty in his OD. Within 4 weeks, the patient presented with anterior sterile keratolysis and partial inlay extrusion, leading to surgical inlay removal.

Contact lens fenestrations and channels in relation to tear exchange and corneal oedema.

Oxygen delivery and tear exchange are considered essential to maintain corneal homoeostasis during contact lens wear. Since the 1940s, fenestrations and back surface channels have been utilised in scleral, corneal rigid, and soft contact lenses in an attempt to enhance corneal oxygen transmission, facilitate the removal of carbon dioxide from the post-lens tear layer, minimise corneal oedema and prevent post-lens tear stagnation. This review examines the use of contact lens fenestrations and channels in both clinical and laboratory settings, and the effect of these modifications upon tear exchange and corneal oedema.

Bacterial endocarditis caused by contact lens usage.

A 17-year-old female was transferred to our hospital due to high fever, general fatigue, and dim eyesight. Three weeks before, she had used cosmetic colored contact lenses and then suffered from bloodshot eyes associated with dim eyesight. Intermittent fever and general fatigue were followed by eye symptoms.

Raman spectroscopy to investigate early biochemical alterations in human tears caused by contact lenses.

Clinical Relevance: The interaction between contact lenses and tear film plays a critical role in lens biocompatibility and can influence discomfort during wear. Early detection of biochemical changes is important for improving ocular surface health, preventing complications, and developing advanced lens materials to enhance long-term comfort.

Background: The pursuit of biocompatible lens materials requires a thorough understanding of their interaction with tear environment.

An unusual cause of hemolacria: retained contact lens in upper fornix.

A 64-year-old male was referred for complaints of blood in tears and bloody discharge of unknown cause in the left eye. The patient was a chronic bandage contact lens (BCL) user. He had no history of recent trauma.

The contact lens-tear film interface: Investigating the tear envelope.

Purpose: To explore the complex interface between the tear film, a unique mucosal fluid which is fundamental to ocular homeostasis and optimal vision, and an in-situ contact lens. This study exploits the use of a unique tear envelope (TE) extraction technique, which harvests the material-influenced layer of tear film that is in intimate contact with the lens during wear, to specifically investigate the influence of contact lens wear on tear film protein dynamics.

Methods: TEs were collected from freshly removed worn lens using a novel microcentrifuge 'piggyback' technique.

Hydrogels as a Potential Biomaterial for Multimodal Therapeutic Applications.

Hydrogels, composed of hydrophilic polymer networks, have emerged as versatile materials in biomedical applications due to their high water content, biocompatibility, and tunable properties. They mimic natural tissue environments, enhancing cell viability and function. Hydrogels' tunable physical properties allow for tailored antibacterial biomaterial, wound dressings, cancer treatment, and tissue engineering scaffolds.

Experimental Study on Ocular Surface Protection by Soft Contact Lenses Due to Volcanic Ash Exposure.

: Sudden volcanic eruptions can lead to volcanic ash entering the eyes, causing severe discomfort and complicating evacuation efforts. The specific effects of volcanic ash on ocular tissues, especially when wearing soft contact lenses (SCLs), are not well documented, prompting this experimental investigation. : White rabbits with normal eyes were randomly divided into three groups: (1) a bare eye group: bare eye + volcanic ash exposure + eye washing, (2) an SCL group: SCL-wearing eye + volcanic ash exposure + eye washing, and (3) a control group: eye washing only.

Ocular thermography and clinical measurements in symptomatic and asymptomatic soft contact lens wearers.

Significance: Symptoms of dryness and discomfort are the main reasons for contact lens dropout. Clinical tests for this purpose are invasive or subjective. Ocular thermography may help to assess the ocular discomfort and dryness in a noninvasive and objective manner.

Tear levels of Transforming Growth Factor-β1 and Interleukin 1-β, and clinical correlations in new contact lens users.

Purpose: To assess alterations in the tear Transforming Growth Factor (TGF)-β1 and Interleukin (IL1)-β concentration in new contact lens wearers; and explore correlations with tear film stability, and ocular physiological response.

Methods: In this clinical setting, 12 neophytes (5 males), with an average age of 24.0 ± 5.

Biomechanical evaluation of different plunger size and plunger position on removing soft contact lenses and rigid gas permeable contact lenses.

Background: To avoid risks of mucosal infection from contact lenses removal, a contact lens plunger is often used.

Objective: Given various types of contact lens plungers available on the market, no study has yet been done on mechanical effects of the contact lens plunger on contact lens removal. Here, this study used finite element analysis to investigate the effects of plunger size and plunger position on the removal of soft and rigid gas permeable (RGP) contact lenses.

Intraoperative variability of corneal epithelium thickness in photorefractive keratectomy.

Purpose: To evaluate the intraoperative central corneal epithelial thickness (ET) as measured by optical coherence pachymetry (OCP) in myopic eyes undergoing alcohol-assisted photorefractive keratectomy (PRK).

Methods: A retrospective review of patients who underwent alcohol-assisted PRK was performed. Data were abstracted on age, gender, contact lens (CL) wear, preoperative refractive errors, keratometry, topographic and ultrasonic pachymetry, and intraoperative OCP measurements before and after epithelium removal.

Proteases, a powerful biochemical tool in the service of medicine, clinical and pharmaceutical.

Proteases, enzymes that hydrolyze peptide bonds, have various applications in medicine, clinical applications, and pharmaceutical development. They are used in cancer treatment, wound debridement, contact lens cleaning, prion degradation, biofilm removal, and fibrinolytic agents. Proteases are also crucial in cardiovascular disease treatment, emphasizing the need for safe, affordable, and effective fibrinolytic drugs.

Application of a practical amniotic membrane ring made on-site for restoration of ocular surface health in dry eye disease.

Purpose: Dry eye disease (DED) is one of the most common ocular surface disorders worldwide. Despite different underlying pathogenic processes, DED is characterized by ocular surface inflammation, which in turn induces further damage to the corneal epithelium and its underlying structures. Amniotic membrane transplants are known to have potent anti-inflammatory effects and also have the ability to enhance epithelial healing.

Uveitis-Glaucoma-Hyphema Syndrome From Subtle Malposition of a Hydrus Microstent.

Uveitis-glaucoma-hyphema (UGH) syndrome is a rare condition characterized by intraocular inflammation, elevated intraocular pressure, and recurrent hyphema. Although UGH syndrome is typically caused by chafing between an intraocular lens and the iris or ciliary body, microinvasive glaucoma devices are becoming increasingly recognized as potential causes of recurrent intraocular inflammation. Herein, we discuss a case of UGH syndrome due to the subtle malposition of a Hydrus microstent that ultimately required surgical removal to manage.

Filamentary keratitis: A review.

Filamentary keratitis (FK) is a clinical sign of underlying ocular and systemic conditions. FK can cause significant irritation, tearing, and photophobia in the eye. It is a refractory debilitating condition caused by dry eye that affects the day-to-day activities of patients.

Absorption and attachment of atropine to etafilcon A contact lenses.

Purpose: Myopia (short-sightedness) is a growing vision problem worldwide. Currently atropine eye drops are used to control the progression of myopia but these suffer from potential lack of bioavailability and low ocular residence time. Commercially available myopia control contact lenses are also used to limit myopia progression, but neither atropine nor contact lenses individually completely stop progression.