Climate data for building simulations with urban heat island effects and nature-based solutions.

As cities face a changing climate, buildings will be subjected to increasing energy demand, heat stress, thermal comfort issues, and decreased service life. Therefore, evaluating building performance under climate change is essential for maintaining sustainable and resilient communities. To better prepare building simulation climate data with urban effects, a computationally efficient approach is used to generate "urbanized" data, where the city's unique signature is obtained through the dynamic Weather Research and Forecasting model for the Ottawa, Canada region.

Co electrospinning -poly (vinyl alcohol)-chitosan/gelatin-poly (-caprolacton) nanofibers for diabetic wound-healing application.

With the increasing prevalence of diabetes, the healing of diabetic wounds has become a significant challenge for both healthcare professionals and patients. Recognizing the urgent need for effective solutions, it is crucial to develop suitable scaffolds specifically tailored for diabetic wound healing. In line with this objective, we have developed novel hybrid nanofibrous scaffolds by combining polyvinyl alcohol/chitosan (PVA/CS) and gelatin/poly(ε-caprolactone) (Gel/PCL) polymers through a double-nozzle electrospinning technique.

Spatial-temporal characteristics and influencing factors of carbon emission in Chengdu-Chongqing area: an urban transportation perspective.

The Chengdu-Chongqing twin-city economic circle is a vital growth pole and a new power source for Chinese high-quality development. Studying the spatial-temporal characteristics of carbon emissions and the role of factors affecting them under the transportation perspective is of great significance for this region to realize the carbon peak and carbon neutrality and to formulate carbon emission reduction policies. We use the exploring spatial data analysis (ESDA) and spatial regression model combined with the STIRPAT model, and research finding: (1) The total carbon emissions in the research area gradually increased from 2014 to 2020, but the growth rate showed a significant decline in 2019.

Research on reliability index and failure probability of inherent defect insurance from the insurance perspective.

With the continuous improvement of people 's living standards, people have put forward higher requirements for the safety and comfort of housing. Therefore, Inherent Defect Insurance, a financial method to guarantee the quality of construction projects, has also emerged. At present, China 's Inherent Defect Insurance has been gradually promoted, but its claim mechanism has not been analyzed and studied.

A framework for prioritizing urban ecological infrastructure (UEI) implementation tasks based on residents' ecological demands and government policies.

With rapid urbanization, balancing urban ecological infrastructure (UEI) construction and residents' ecological demands (RED) has become an imperative but challenging issue for sustainable development. This study develops an integrated framework to systematically prioritize UEI implementation based on localized RED and government policies. We incorporate the Kano model and quality function deployment (QFD) approach to quantify the complex associations between various resident needs and existing policies.

Experimental and Finite Element Simulation of Polyolefin Elastomer Foams Using Real 3D Structures: Effect of Foaming Agent Content.

In this study, polyolefin elastomer (POE) foams were prepared without any curing agent using a single-step foaming technique. The effect of azodicarbonamide (ADC) content as a chemical foaming agent on the foams' morphology and mechanical properties was studied using scanning electron microscopy (SEM), mechanical properties (tension and compression) and hardness. The results showed that increasing the ADC content from 2 to 3, 4 and 5 phr (parts per hundred rubber) decreased the foam density from 0.

Papillary thyroid carcinoma occurring with undifferentiated pleomorphic sarcoma: A case report.

Background: Papillary thyroid cancer (PTC) is the most common malignant tumor of the thyroid. However, the coexistence of PTC and sarcoma in one patient is rare. In this article, we report the case of a patient who presented with both PTC and undifferentiated pleomorphic sarcoma (UPS), which has not been previously reported in the online Medline database (PubMed).

Enhancing the In-Plane Behavior of a Hybrid Timber Frame-Mud and Stone Infill Wall Using PP Band Mesh on One Side.

Traditional village dwellings in China consisting of timber frames with mud and stone infill walls represent an important part of cultural heritage and civilization. Due to the lack of an effective link between the wood frame and the infill and the poor cohesiveness of clay, the masonry infill can collapse during an earthquake, whereas the wood frame suffers minimal damage. In this study, current retrofitting techniques for village buildings were investigated and discussed.

Lymphocyte infiltration and thyrocyte destruction are driven by stromal and immune cell components in Hashimoto's thyroiditis.

Hashimoto's thyroiditis (HT) is the most common autoimmune disease characterized by lymphocytic infiltration and thyrocyte destruction. Dissection of the interaction between the thyroidal stromal microenvironment and the infiltrating immune cells might lead to a better understanding of HT pathogenesis. Here we show, using single-cell RNA-sequencing, that three thyroidal stromal cell subsets, ACKR1 endothelial cells and CCL21 myofibroblasts and CCL21 fibroblasts, contribute to the thyroidal tissue microenvironment in HT.

DAPK2 activates NF-κB through autophagy-dependent degradation of I-κBα during thyroid cancer development and progression.

Background: Death-associated protein kinase 2 (DAPK2) is a serine/threonine kinase, which has been implicated in autophagy and apoptosis. DAPK2 functions as a tumor suppressor in various cancers. However, the role of DAPK2 in thyroid cancer (TC) is unclear.

A five-gene panel refines differential diagnosis of thyroid nodules.

Background: Molecular testing for oncogenic mutations in fine-needle aspiration has showed high predictive value in identifying malignant lesions from thyroid nodules with indeterminate cytology.

Methods: To figure out an efficient and economical gene panel for most medical institutions in China, we designed a five-gene panel including BRAF/NRAS/KRAS/HRAS/TERT genes and conducted a retrospective study to evaluate the role of this five-gene diagnostic panel in differential diagnosis of thyroid nodules.

Results: A total of 665 patients with 695 thyroid nodules were investigated in the current study.

Treatment of leiomyomatosis peritonealis disseminata with goserelin acetate: A case report and review of the literature.

Background: Leiomyomatosis peritonealis disseminata (LPD) is a rare condition characterized by multiple pelvic and abdominal nodules, which are composed of smooth-muscle cells. To date, no more than 200 cases have been reported. The diagnosis of LPD is difficult and there are no guidelines on the treatment of LPD.

Physical Hybrid of Nanographene/Carbon Nanotubes as Reinforcing Agents of NR-Based Rubber Foam.

Natural rubber (NR) foams reinforced by a physical hybrid of nanographene/carbon nanotubes were fabricated using a two-roll mill and compression molding process. The effects of nanographene (GNS) and carbon nanotubes (CNT) were investigated on the curing behavior, foam morphology, and mechanical and thermal properties of the NR nanocomposite foams. Microscope investigations showed that the GNS/CNT hybrid fillers acted as nucleation agents and increased the cell density and decreased the cell size and wall thickness.

Residual tumor and central lymph node metastasis after thermal ablation of papillary thyroid carcinoma: A case report and review of literature.

Background: Debate exists regarding the use of thermal ablation (TA) to treat papillary thyroid carcinoma (PTC). Some studies have recommended TA as a new, efficient and safe technology for PTC. In this article, we report one case of a residual tumor and central lymph node metastasis (CLNM) after TA for PTC.

Continuous postoperative negative pressure irrigation assisted mammaplasty in treating chronic refractory plasma cell mastitis.

Background: Chronic refractory plasma cell mastitis (CRPCM) is an aseptic inflammation of the breast with a chronic course of the disease, extended treatment cycle (months to years), with a high recurrence rate. The objective of this study was to evaluate the efficacy of continuous postoperative negative pressure irrigation assisted mammaplasty (CPNPIAM) in treating CRPCM.

Methods: Between 2016 and 2018, 36 CRPCM patients receiving CPNPIAM were enrolled in this study.

Sagliker syndrome: A case report of a rare manifestation of uncontrolled secondary hyperparathyroidism in chronic renal failure.

Background: Sagliker syndrome (SS) resulting from uncontrolled secondary hyperparathyroidism (SHPT) in chronic renal failure (CRF) is seldom reported.

Case Summary: A 24-year-old woman presented with asymmetric facial deformity and stature shortening. She was diagnosed with SS, SHPT, CRF, and thyroid cancer.

Early detection of Alzheimer's disease by peptides from phage display screening.

Alzheimer's disease (AD) is the most common neurodegenerative disorder without effective treatment so far. As clinical trials show that early-stage patients are more likely to respond to potential interventions, various technologies have been used to search blood biomarkers for the early diagnosis of AD. Phage display could be used to select specific peptides against desired target and here, we established a peptide binding assay based on phage display peptide library to detect early-stage AD patients.

IL-18 induced IL-23/IL-17 expression impairs Aβ clearance in cultured THP-1 and BV2 cells.

Recent studies have provided overwhelming evidence of the involvement of microglia-related molecular networks in the pathogenesis of Alzheimer's diseases (AD). The potential involvement of pro-inflammatory cytokines interleukin (IL)-18, IL-23 and IL-17 on amyloid (Aβ) clearance is still unclear. In this study, we addressed that there might be a net relationship among IL-18, IL-23, and IL-17 and they can affect Aβ clearance in cultured macrophage/microglia cells.

TRPC6 mRNA levels in peripheral leucocytes of patients with Alzheimer's disease and mild cognitive impairment: A case-control study.

Background: Transient receptor potential canonical (TRPC) 6 inhibits Aβ in Alzheimer's disease (AD) mouse brain and improves the behavioral performance.

Aims: To evaluate the association of TRPC6 expression in peripheral leucocytes from AD and mild cognitive impairment (MCI) patients and to explore its potential value in early diagnosis of AD.

Methods: TRPC6 mRNA levels in peripheral leucocytes were detected by quantitative real-time PCR.

Association of neck circumference and cognitive impairment among Chinese elderly.

Objectives: To investigate the association between neck circumference (NC) and cognitive impairment and interactions between relevant variables to the risk of cognitive impairment.

Methods: A population-based survey was conducted among elderly inhabitants aged 60 years and over from a community in Shanghai suburb. Multivariate logistic regression analyses were performed to evaluate associations and log likelihood ratio tests to examine interactions.

Inhibition of cell-adhesion protein DPYSL3 promotes metastasis of lung cancer.

Background: Our previous screening study suggested that the cell-adhesions protein Dihydropyrimidinase-like 3 (DPYSL3) was a candidate metastatic lung cancer related molecule. This study aimed to analyze the correlation between DPYSL3 and metastatic lung cancer.

Methods: Stable DPYSL3 knockdown Lewis lung carcinoma (LLC) cells were constructed with a retroviral system.

Comparison of breast-conserving surgery with mastectomy in locally advanced breast cancer after good response to neoadjuvant chemotherapy: A PRISMA-compliant systematic review and meta-analysis.

Background: The application of breast-conserving surgery (BCS) on patients with locally advanced breast cancer (LABC) with good response to neoadjuvant chemotherapy (NACT) still remains controversial. The objective in this study is to analyze the safety of BCS in the management of LABC in patients with good response to NACT.

Methods: We searched the electronic databases of Medline (Pubmed) and Cochrane Library for reports on local recurrence (LR), regional recurrence (RR), distant recurrence (DR), 5-year disease-free survival (DFS) or 5-year overall survival (OS) in patients with LABC receiving BCS or mastectomy (MT) and with good response to NACT.

Wind tunnel and numerical data on the ventilation performance of windcatcher with wing wall.

The data presented in this article were the basis for the study reported in the research articles entitled "Evaluation of a two-sided windcatcher integrated with wing wall (as a new design) and comparison with a conventional windcatcher" (P. Nejat, J.K.