131 results match your criteria: "Consorci Hospital General Universitari[Affiliation]"

Objectives: To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality.

Methods: ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively.

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Justification and objectives: The Spanish Academy of Dermatology and Venereology (AEDV) Psoriasis and Pediatric Working Groups (PSW and PWG) have developed a set of recommendations for the management of pediatric psoriasis based on the best available evidence and experts' opinion. Methodology: The methodology of nominal groups was followed, with help from a scoping review. A coordinator was designated, and a group of experts was selected based on their experience and knowledge on the management of psoriasis.

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  • The study investigates the effectiveness of the mySugr mobile app for diabetes management combined with teleconsultations compared to standard clinical care for patients with type 1 diabetes mellitus (T1DM).
  • Conducted over 12 months, participants were divided into two groups: one using the mySugr app and the other receiving usual clinical care; outcomes measured included patient empowerment and glucose-related metrics.
  • Results showed no significant differences between the groups in most health outcomes, although the app users had better variability in glucose levels, indicating that the mySugr app is a viable alternative to traditional care methods despite similar overall effectiveness.
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Unlabelled: In recent years, there has been an increase in the practice of chemsex, which is becoming an increasingly serious public health problem. The complex interaction between chemsex and mental health underscores the need to understand the psychological, social, and environmental factors that influence this practice.

Methods: A qualitative descriptive phenomenological study was conducted in the community of Madrid, Spain to explore the depth of the chemsex phenomenon through a thematic analysis.

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  • Severe recurrent aphthous stomatitis (RAS) significantly affects quality of life, and currently, no approved systemic treatments exist, prompting the exploration of roflumilast, a phosphodiesterase-4 inhibitor.
  • In a study involving 22 RAS patients across five Spanish centers, roflumilast treatment resulted in substantial improvements, including an 88% reduction in flare-ups and a 94% decrease in oral ulcers over 12 weeks.
  • Despite some adverse effects (mainly headache and gastrointestinal issues), roflumilast was generally well tolerated, showing promise as an effective and safe treatment option for RAS.
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The DEBBRAH trial: Trastuzumab deruxtecan in HER2-positive and HER2-low breast cancer patients with leptomeningeal carcinomatosis.

Med

January 2025

Medica Scientia Innovation Research (MEDSIR) - Oncoclínicas&Co, Jersey City, NJ, USA; International Breast Cancer Center (IBCC), Pangaea Oncology, Quiron Group, Barcelona, Spain; Universidad Europea de Madrid, Faculty of Biomedical and Health Sciences, Department of Medicine, Madrid, Spain. Electronic address:

Article Synopsis
  • Leptomeningeal disease (LMD) significantly impacts survival and quality of life, and trastuzumab deruxtecan (T-DXd) has demonstrated effectiveness in treating advanced HER2-positive and HER2-low breast cancer in patients with a history of brain metastases or LMD.
  • In a phase 2 trial involving seven patients with confirmed LMD, T-DXd was administered, revealing a median overall survival (OS) of 13.3 months and a progression-free survival (PFS) of 8.9 months, with many patients achieving disease stabilization.
  • The results suggest T-DXd has promising activity in this challenging patient population, indicating a need for further research on its efficacy in treating LMD.
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Background: Mucocutaneous Behçet disease often presents a therapeutic challenge. Roflumilast has shown promise in the treatment of other inflammatory dermatological conditions.

Objectives: The objective of this study was to evaluate the characteristics, effectiveness and safety of roflumilast in the treatment of Behçet disease-associated aphthosis in routine clinical practice.

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Consensus Statement from the Spanish Academy of Dermatology and Venereology (AEDV) Psoriasis Working Group (SWG) and Pediatric Working Group (PWG) on the Management of Pediatric Psoriasis.

Actas Dermosifiliogr

July 2024

Departamento de Dermatología, Hospital Universitari Germans Trias i Pujol, Germans Trias I Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona, Badalona, Barcelona, España.

Justification And Objectives: The Spanish Academy of Dermatology and Venereology (AEDV) Psoriasis and Pediatric Working Groups (PSW and PWG) have developed a set of recommendations for the management of pediatric psoriasis based on the best available evidence and experts' opinion.

Methodology: The methodology of nominal groups was followed, with help from a scoping review. A coordinator was designated, and a group of experts was selected based on their experience and knowledge on the management of psoriasis.

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  • The study aimed to evaluate how the diagnostic process and time to treatment for idiopathic pulmonary fibrosis (IPF) patients changed from 2011 to 2019, in relation to updates in clinical practice guidelines.
  • A total of 929 out of 1064 patients from a registry were analyzed, revealing that diagnosis methods evolved over time, with a shift from surgical biopsies to non-invasive imaging like chest CT scans.
  • Key findings showed that the average time from symptom onset to diagnosis was 360 days, and many patients experienced delays in receiving antifibrotic treatment, indicating a need for improved diagnostic efficiency.
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Background: A nationwide, prospective, multicenter, cohort study (the Disease-Related caloric-protein malnutrition EChOgraphy (DRECO) study) was designed to assess the usefulness of ultrasound of the rectus femoris for detecting sarcopenia in hospitalized patients at risk of malnutrition and to define cut-off values of ultrasound measures.

Methods: Patients at risk of malnutrition according to the Malnutrition Universal Screening Tool (MUST) underwent handgrip dynamometry, bioelectrical impedance analysis (BIA), a Timed Up and Go (TUG) test, and rectus femoris ultrasound studies. European Working Group on Sarcopenia in Older People (EWGSOP2) criteria were used to define categories of sarcopenia (at risk, probable, confirmed, severe).

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Background: X-linked hypophosphatemia (XLH) represents the most prevalent cause of hereditary hypophosphatemia. X-linked hypophosphatemia causes an elevation of fibroblast growth factor 23 (FGF23), a hormone responsible for inducing hyperphosphaturia, and reduced active vitamin D synthesis. Challenges in diagnosis and the absence of well-defined clinical guidelines have resulted in higher rates of late diagnoses.

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Seven- and thirty-day mortality in digoxin poisoning: Results from the DIGITOX study.

Am J Emerg Med

July 2024

Fundación Española de Toxicología Clínica, Spain; Emergency Department, Hospital Universitario de Canarias, Tenerife, Spain; Department of Physical Medicine and Pharmacology, Universidad de La Laguna, Tenerife, Spain.

Background: Digoxin poisonings are relatively common and potentially fatal, requiring immediate therapeutic intervention, with special attention to the patient's hemodynamic status and the presence of electrocardiographic and electrolytic disturbances.

Objective: To identify factors associated with seven-day and thirty-day mortality in digoxin poisoning.

Design, Settings And Participants: A retrospective, observational, multicenter study was conducted across 15 Hospital Emergency Departments (HED) in Spain.

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Article Synopsis
  • X-linked hypophosphatemia (XLH) is a genetic disorder linked to increased levels of fibroblast growth factor 23 (FGF23) and a higher risk of early-onset hypertension, but the exact causes of hypertension in XLH patients remain unclear.
  • A multicenter study of 20 adult XLH patients found that 45% had hypertension, with significant differences in creatinine and LDL cholesterol levels compared to those without hypertension.
  • The study also identified 106 metabolites, with several showing significant differences between hypertensive and non-hypertensive patients, potentially providing insights into hypertension mechanisms in XLH and guiding future research on biomarkers and diagnostics.
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Our study assessed the characteristics of people living with HIV (PLWH) detected via opportunistic screening in Valencia (Spain) to determine diagnoses potentially missed under a more restrictive, indicator-condition diagnostic strategy. We conducted a retrospective analysis of electronic health records of 97 PLWH diagnosed between April 2019 and August 2022. The main outcomes reported were patient CD4 T cell count, known HIV risk factors at diagnosis, and missed opportunities for diagnosis, defined as the failure of a previously untested patient to undergo HIV testing despite attending previous visits to healthcare facilities prior to diagnosis.

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Background: Around 57,000 people in Spain and Portugal currently living with HIV or chronic hepatitis C are unaware of their infection. The COVID-19 pandemic severely disrupted screening efforts for these infections. We designed an intervention to increase and sustain opportunistic blood-borne virus (BBV) screening and linkage to care (SLTC) by implementing the TEST model.

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Diagnosis of pityriasis lichenoides et varioliformis acuta (PLEVA) is based on the characteristic pattern of lesions in different stages of development, ranging from erythematous maculopapules to papules with a crusted and/or necrotic centre. However, it may raise the differential diagnosis with other entities. It is therefore not uncommon to have to perform skin biopsies to reach a diagnosis, including in infants.

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Objectives: Digoxin toxicity accounts for a small percentage of poisonings attended by emergency departments. This study aimed to describe differences between acute and chronic digoxin toxicity and assess the use of digoxin-specific antibody fragments (digoxin-Fab) as an antidote.

Material And Methods: Retrospective, observational, multicenter study in 15 hospital emergency departments in 8 Spanish autonomous communities in 7 years.

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  • A study evaluated the effectiveness and safety of single capsule bismuth quadruple therapy (scBQT) administered three times a day, as opposed to the recommended four times a day schedule, focusing on ease of adherence.
  • Out of 3,712 cases analyzed, the three times a day regimen showed a higher cure rate of 94% compared to 91% for the four times a day schedule, though adherence and safety were similar.
  • The findings suggest that the three times a day scBQT regimen is more effective, with factors like treatment adherence and the type of proton pump inhibitor used being significant predictors of infection cure.
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