Predicting Elevated Postvoid Residual Urine Volume Following OnabotulinumtoxinA Treatment for Overactive Bladder: A Pilot Study.

Objectives: To evaluate possible predictors of elevated postvoid residual volume (PVR) following onabotulinumtoxinA administration in patients with idiopathic overactive bladder (OAB), a condition that may include urinary urgency, frequency, and nocturia, without any identifiable cause or underlying neurological or metabolic condition.

Methods: Adults who had been treated with 100-200 U onabotulinumtoxinA for OAB and had previous failure of other OAB treatments were identified by retrospective review of medical chart data from three urology clinics in the United States treating patients with a variety of urological conditions. A total of 211 patients were allocated to cohorts based on posttreatment PVR < 200 mL (n = 173) and ≥ 200 mL (n = 38).

Advances and challenges in green extraction of chitin for food and agriculture applications: A review.

Chitin, the second most abundant polysaccharide in nature, offers numerous practical applications due to its versatile functional properties. However, its utilization is constrained by significant challenges in extraction, as well as low solubility and high crystallinity. While traditional chemical and biological fermentation methods can achieve high-purity chitin, these processes are often environmentally harmful or time/energy-consuming.

Social functioning and frontal alpha asymmetry in schizophrenia.

Background: Schizophrenia (SZ) is a psychiatric disorder that often involves reduced social functioning. Frontal alpha asymmetry (FAA) is a neurophysiological marker extracted from electroencephalogram (EEG) data that is likely related to motivational and emotional tendencies, such as reduced motivation across various psychiatric disorders, including SZ. Therefore, it may offer a neurophysiological marker for social functioning.

Preliminary Evidence for Perturbation-Based tACS-EEG Biomarkers of Gamma Activity in Alzheimer's Disease.

Background: Alzheimer's disease (AD) is characterized by impaired inhibitory circuitry and GABAergic dysfunction, which is associated with reduced fast brain oscillations in the gamma band (γ, 30-90 Hz) in several animal models. Investigating such activity in human patients could lead to the identification of novel biomarkers of diagnostic and prognostic value. The current study aimed to test a multimodal "Perturbation-based" transcranial Alternating Current Stimulation-Electroencephalography (tACS)-EEG protocol to detect how responses to tACS in AD patients correlate with patients' clinical phenotype.

Efficient Gene Delivery Admitted by small Metabolites Specifically Targeting Astrocytes in the Mouse Brain.

The development of efficient and targeted methods for delivering DNA in vivo has long been a major focus of research. In this study, we introduce a gene Delivery approach Admitted by small Metabolites, named gDAM, for the efficient and targeted delivery of naked DNA into astrocytes in the adult brains of mice. gDAM utilizes a straightforward combination of DNA and small metabolites, including glycine, L-proline, L-serine, L-histidine, D-alanine, Gly-Gly, and Gly-Gly-Gly, to achieve astrocyte-specific delivery of naked DNA, resulting in transient and robust gene expression in these cells.

Lower limb strength differentiates between fallers and non-fallers with multiple sclerosis.

Objective: To determine whether hip flexion (HF), extension (HE), abduction (HA), knee flexion (KF) and extension (KE), and ankle plantarflexion (APF) and dorsiflexion (ADF) Maximum Voluntary Contraction (MVC) differentiates between non-fall and fall history in persons with MS (PwMS) after accounting for age, gender, fatigue, disability, and disease duration.

Design: Secondary analysis of a cross-sectional study.

Setting: Community-based comprehensive MS Center PARTICIPANTS: 172 persons with MS who completed a one-time visit INTERVENTIONS: Not applicable MAIN OUTCOME MEASURES: Lower limb (LL) MVC was measured for each muscle group as isometric peak torque (Newton-meter: Nm) of both limbs (Strongest: S; Weakest: W) using a Biodex Dynamometer and normalized by body weight (Nm/kg).

Examining tobacco use at the intersection of gender, sexual orientation, race, and ethnicity using national U.S. data of sexual and gender diverse youth.

Objectives: To expand the literature documenting that tobacco use inequities persist and continue to increase for minoritized youth populations by exploring patterns of tobacco use across multiple intersections of sexual, gender, racial, and ethnic identities. Studies with this focus are needed to understand the degree to which tobacco use varies across groups who hold multiple minoritized identities.

Methods: The current study used a novel analytical approach- Exhaustive Chi-square Automatic Interaction Detection - to examine lifetime cigarette use among a U.

State of the Art in Left Atrial Appendage Occlusion.

Left atrial appendage occlusion (LAAO) has become an important therapeutic target for stroke prevention in patients with nonvalvular atrial fibrillation. Over the past 2 decades, several advancements in LAAO devices (percutaneous and surgical) have been made for stroke prevention and arrhythmia therapy. However, there are several unanswered questions regarding optimal patient selection, the preferred LAAO approach and device, the management of periprocedural and postprocedural complications, including pericardial effusion, device-related thrombus, and device leaks.

The PERFORMANCE II Trial: A Prospective Multicenter Investigation of a Novel Carotid Stent System.

Background: Several randomized clinical trials have shown that the composite endpoint of death, stroke, and myocardial infarction (MI) is equivalent between carotid artery stenting and carotid endarterectomy. However, the risk of minor stroke has been consistently higher with carotid artery stenting.

Objectives: The authors sought to evaluate the safety and effectiveness of a novel carotid stent system comprised of a stent, an adjustable integrated embolic filter and a postdilation balloon, in patients at elevated risk for adverse events from carotid endarterectomy.

New Insights Into Hepatic Impairment (HI) Trials.

Hepatic impairment (HI) trials are traditionally part of the clinical pharmacology development to assess the need for dose adaptation in people with impaired metabolic capacity due to their diseased liver. This review aimed at looking into the data from dedicated HI studies, cluster these data into various categories and connect the effect by HI with reported pharmacokinetics (PK) properties in order to identify patterns that may allow waiver, extrapolations, or adapted HI study designs. Based on a ratio ≥ 2 or ≤ 0.

Integrated Analysis of Single-Cell and Bulk RNA Data Reveals Complexity and Significance of the Melanoma Interactome.

Despite significant strides in anti-melanoma therapies, resistance and recurrence remain major challenges. A deeper understanding of the underlying biology of these challenges is necessary for developing more effective treatment paradigms. Melanoma single-cell data were retrieved from the Broad Single Cell Portal (SCP11).

Nutrition Knowledge and Perceived Dietary Requirements of Adolescent Student-Athletes: A Pilot Study.

Background/objectives: Adherence to sports-specific nutritional guidelines can help optimize athlete performance and health. However, adolescent athletes may not have adequate nutrition knowledge and understanding of specific nutritional requirements. The objective of the current study was to examine the nutrition knowledge and perceived dietary requirements of adolescent athletes.

Emerging Biomarkers and Determinants of Lipoprotein Profiles to Predict CVD Risk: Implications for Precision Nutrition.

Biomarkers constitute a valuable tool to diagnose both the incidence and the prevalence of chronic diseases and may help to inform the design and effectiveness of precision nutrition interventions. Cardiovascular disease (CVD) continues to be the foremost cause of death all over the world. While the reasons that lead to increased risk for CVD are multifactorial, dyslipidemias, plasma concentrations of specific lipoproteins, and dynamic measures of lipoprotein function are strong biomarkers to predict and document coronary heart disease incidence.

Contextual cues can be used to predict the likelihood of and reduce interference from salient distractors.

Our attention can sometimes be disrupted by salient but irrelevant objects in the environment. This distractor interference can be reduced when distractors appear frequently, allowing us to anticipate their presence. However, it remains unknown whether distractor frequency can be learned implicitly across distinct contexts.

The International System for Serous Fluid Cytopathology (TIS) survey in preparation for TIS 2.0.

Introduction: The International System for Serous Fluid Cytopathology (TIS) has gained acceptance and has led to literature validating original concepts and suggesting refinements. In preparation for the second edition of TIS, editors generated a survey to solicit experience with and opinions about TIS.

Materials And Methods: An online survey available from March 8 to June 15, 2024, included 56 questions, offered in 7 languages, related to the practice of serous fluid cytopathology.

Micro-nanoscale polystyrene co-exposure impacts the uptake and translocation of arsenic and boscalid by lettuce (Lactuca sativa).

The influence of micro-nanoplastics (MNPs) on the fate and effects of other pollutants present in the environment is largely unknown. This study evaluated if the root exposure to MNPs (polystyrene, PS; 20 or 1000 nm) had an impact on the accumulation of arsenic and boscalid (As and Bos) in lettuce (Lactuca sativa). Under hydroponic conditions, plants were co-exposed to MNPs at 10 or 50 mg/L, and to 1 mg/L of each environmental pollutant (EP).

Prediction of Aneurysm Sac Shrinkage After Endovascular Aortic Repair Using Machine Learning-Based Decision Tree Analysis.

Introduction: A simple risk stratification model to predict aneurysm sac shrinkagein patients undergoing endovascular aortic repair (EVAR) for abdominal aortic aneurysms (AAA) was developed using machine learning-based decision tree analysis.

Methods: One hundred nineteen patients with AAA who underwent elective EVAR at Tokyo Medical University Hospital between November 2013 and July 2019 were included in the study. Predictors of aneurysm sac shrinkage identified in univariable analysis (P < 0.

Preferences for Inguinal Hernia Repair in Infants: A Survey of the Eastern Pediatric Surgery Network.

Introduction: Laparoscopic inguinal hernia repair (IHR) is being performed more frequently in children, but few studies have evaluated surgical practice patterns in infants. In this study, we surveyed pediatric surgeons within a regional consortium to assess current preferences for IHR strategy in infants. We hypothesized that early-career pediatric surgeons would prefer laparoscopic IHR over open IHR in this patient population.