3 results match your criteria: "Conn (M.M.); and University of California San Francisco[Affiliation]"
PTC124 targets genetic disorders caused by nonsense mutations.
Nature
May 2007
PTC Therapeutics, 100 Corporate Court, South Plainfield, New Jersey 07080, USA.
Nonsense mutations promote premature translational termination and cause anywhere from 5-70% of the individual cases of most inherited diseases. Studies on nonsense-mediated cystic fibrosis have indicated that boosting specific protein synthesis from <1% to as little as 5% of normal levels may greatly reduce the severity or eliminate the principal manifestations of disease. To address the need for a drug capable of suppressing premature termination, we identified PTC124-a new chemical entity that selectively induces ribosomal readthrough of premature but not normal termination codons.
View Article and Find Full Text PDFSelf-Assembling Capsules.
Chem Rev
August 1997
Department of Chemistry, Amherst College, Amherst, Massachusetts 01002-5000, and Skaggs Institute for Chemical Biology and the Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, California 92037.
Hydrogen bonding in water using synthetic receptors.
Proc Natl Acad Sci U S A
February 1995
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139.
Four water-soluble adenine receptors were synthesized to study the influence of hydrophobic interactions and hydrogen bonding on molecular recognition in aqueous solution. Association constants were measured in aqueous solution at five temperatures from 3-27 degrees C (pH 6, 51 mM ionic strength). For the mono(imide) receptors, delta H was -5.
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