10,893 results match your criteria: "Congenital Myopathies"
J Biomol Struct Dyn
November 2024
Department of Biosciences, Jamia Millia Islamia, New Delhi, India.
Clinical phenotypic presentations associated with LAMA2 deficiency have shown a variety of manifestations. LAMA2 mutations are mainly linked to congenital muscular dystrophy, but there is also mounting evidence suggesting their presence in inflammatory breast cancer, laryngopharyngeal squamous cell carcinoma, and ventricular tachycardia related to coronary artery disease and cardiomyopathy. This study examined the structural and functional impacts of 144 non-synonymous single nucleotide polymorphisms (nsSNPs) within the LAMA2 gene.
View Article and Find Full Text PDFMolecules
November 2024
Department of Life and Environmental Sciences, Cittadella Universitaria di Monserrato, Blocco A, Room 13, 09042 Monserrato, Italy.
GNE myopathy, also known as hereditary inclusion body myopathy (HIBM), is a rare genetic muscle disorder marked by a gradual onset of muscle weakness in young adults. GNE myopathy (GNEM) is caused by bi-allelic variants in the UDP--acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase)/-acetylmannosamine kinase (ManNAc kinase) gene (), clinically resulting in the loss of ambulation within 10-20 years from the onset of the initial symptoms. The disease's mechanism is poorly understood and non-invasive biomarkers are lacking, hindering effective therapy development.
View Article and Find Full Text PDFNeuromuscul Disord
December 2024
TY Nelson Department of Neurology and Neurosurgery, The Children's Hospital at Westmead, Sydney, NSW, Australia.
Int J Surg Case Rep
December 2024
Algiers university, Head of Orthopaedic Department, University Hospital Center Lamine DEBAGHINE, Bab El Oued, Algiers, Algeria.
Introduction: Compartment syndrome is a surgical emergency caused by elevated pressure within a closed fascial compartment, leading to compromised tissue perfusion and the potential for irreversible damage if not treated promptly. This report presents a rare case of upper limb compartment syndrome in a COVID-19 patient on anticoagulation therapy following multiple failed venipuncture attempts. This work has been reported in line with the SCARE criteria.
View Article and Find Full Text PDFencodes the mitochondrial coenzyme A (CoA) transporter localized at the inner mitochondrial membrane. SLC25A42 deficiency leads to a congenital disease with a heterogeneous clinical presentation, including myopathy, developmental delay, lactic acidosis, and encephalopathy. Twenty-one patients have been described so far.
View Article and Find Full Text PDFBiochem Biophys Rep
December 2024
Department of Pediatric Orthopedics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China.
Neuromuscular scoliosis can be caused by muscular or nervous system dysfunction resulting from genetic variants. Variation in may cause hypertrophic or dilated cardiomyopathy, skeletal myopathies, or a combination of both; however, scoliosis has rarely been reported. We analyzed a Chinese pedigree with two members suffering from scoliosis.
View Article and Find Full Text PDFNeurol Sci
October 2024
Service of Neuromuscular Disorders, Division of Neurology, Department of Internal Medicine, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, 80060-900, Brazil.
We report a 9-year-old girl with delayed motor milestones and respiratory difficulty since birth. She presented as a floppy infant, with generalised muscle wasting, dysphagia and facial weakness. The muscle biopsy of the biceps brachii revealed congenital fibre-type disproportion (CFTD) and Sanger sequencing detected a pathogenic variant in the beta-tropomyosin (TPM2) gene (c.
View Article and Find Full Text PDFNeurology
November 2024
From the Department of Neurology (A.R.S., M.M., D.S., T.L.), Mayo Clinic, Rochester, MN; Department of Laboratory Medicine and Pathology (O.N.), Hennepin Healthcare, Minneapolis, MN; Department of Neurology (A.C.M.), University of North Carolina, Chapel Hill; Department of Neurology (A.S.), Northwestern University, Chicago, IL; Division of Rheumatology (C.H.), Department of Medicine, Northwestern University, Chicago, IL; Departments of Laboratory Services (W.F.R.), Neurology (M.M.A.), and Medicine (R.M.A.), Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Center for Gene Therapy (S.N.), Nationwide Children's Hospital, Columbus, OH; and Department of Medicine (P.S.), Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Front Pediatr
October 2024
Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, Gansu, China.
Nemaline myopathy (NM) is a rare congenital muscle disease that leads to muscle damage, resulting in muscle weakness and atrophy. Cases of scoliosis induced by muscle weakness and atrophy are exceedingly uncommon. The author clinically treated one patient with NM complicated by scoliosis and analyzed its clinical characteristics through a literature review.
View Article and Find Full Text PDFActa Myol
September 2024
Neuromuscular Unit, Department of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy.
Introduction And Aims: We describe a case of long-living COLQ-related congenital myasthenic syndrome (CMS) benefitting from ephedrine with an overall improvement quantified with functional measures.
Results: A 71-year-old man was referred with limb-girdle/axial myopathy and fatigability since infancy. In his thirties, a decremental response was observed at 3Hz-nerve stimulation, although testing seronegative for anti-neuromuscular junction antibodies.
FASEB J
October 2024
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, USA.
Pathogenic variants in the type I ryanodine receptor (RYR1) result in a wide range of muscle disorders referred to as RYR1-related myopathies (RYR1-RM). We developed the first RYR1-RM mouse model resulting from co-inheritance of two different RYR1 missense alleles (Ryr1 mice). Ryr1 mice exhibit a severe, early onset myopathy characterized by decreased body/muscle mass, muscle weakness, hypotrophy, reduced RYR1 expression, and unexpectedly, incomplete postnatal lethality with a plateau survival of ~50% at 12 weeks of age.
View Article and Find Full Text PDFFront Cardiovasc Med
October 2024
Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
J Vet Intern Med
November 2024
Institute of Genetics, Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Background: Skeletal dysplasia encompasses a heterogeneous group of genetic disorders characterized by an abnormal development of bones, joints, and cartilage. Two Chianina half-sibling calves from consanguineous mating with congenital skeletal malformations and cardiac abnormalities were identified.
Hypothesis/objectives: To characterize the disease phenotype, to evaluate its genetic cause, and to determine the prevalence of the deleterious alleles in the Chianina population.
Genes (Basel)
September 2024
Department of Intensive Care and Congenital Malformations of Newborns and Infants, Polish Mother's Memorial Hospital-Research Institute, 93-338 Lodz, Poland.
This paper discusses the cases of siblings that were born healthy, then diagnosed in their neonatal periods with cardiomyopathy and/or severe metabolic acidosis, which ran progressive courses and contributed to death in infancy. Molecular testing of the children confirmed the presence of an m.3303C>T point mutation in the mitochondrial DNA in the gene, which was also present in their oligosymptomatic mother and their mother's sister, an asymptomatic carrier.
View Article and Find Full Text PDFAnn Clin Transl Neurol
December 2024
Center for Inherited Myology Research, Virginia Commonwealth University, Richmond, Virginia, 23298, USA.
Eur J Hum Genet
October 2024
Department of Medical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
An increasing number of individuals with intellectual developmental disorder (IDD) and heterozygous variants in BCL11A are identified, yet our knowledge of manifestations and mutational spectrum is lacking. To address this, we performed detailed analysis of 42 individuals with BCL11A-related IDD (BCL11A-IDD, a.k.
View Article and Find Full Text PDFEur J Paediatr Neurol
November 2024
Department of Clinical Neurosciences for Children, Oslo University Hospital, Oslo, Norway; Section for Rare Neuromuscular Disorders and Unit for Congenital and Hereditary Neuromuscular Disorders (EMAN), Department of Neurology, Oslo University Hospital, Oslo, Norway.
BMC Neurol
October 2024
Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Background: SELENON-related myopathy (SELENON-RM) is a rare congenital myopathy characterized by slowly progressive axial muscle weakness, rigidity of the spine, scoliosis, and respiratory insufficiency. Laminin-a2-related muscular dystrophy (LAMA2-MD) has a similar clinical phenotype, which ranges from severe, early-onset congenital muscular dystrophy type 1A (MDC1A) to milder forms presenting as childhood- or adult-onset limb-girdle type muscular dystrophy. The first 1.
View Article and Find Full Text PDFWien Med Wochenschr
October 2024
Department of Pediatric Neurosurgery, National Institute of Children´s Diseases, Limbova 1, 83340, Bratislava, Slovakia.
Neuromuscul Disord
November 2024
Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Instituto Neurologico Carlo Besta, Milano, Italy. Electronic address:
The 275th ENMC workshop on the diagnosis and management of seronegative myasthenia gravis (SNMG) was held on February 9-11, 2024. The participants included experts in the field of adult and pediatric MG together with patient representatives. This workshop aimed to redefine SNMG in view of recent diagnostic and therapeutic updates and to identify patient unmet needs.
View Article and Find Full Text PDFBMC Vet Res
October 2024
Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, Faculty of Health and Lifesciences, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, UK.
Inherited and acquired muscle diseases are an important cause of morbidity and mortality in human medical and veterinary patients. Researchers use models to study skeletal muscle development and pathology, improve our understanding of disease pathogenesis and explore new treatment options. Experiments on laboratory animals, including murine and canine models, have led to huge advances in congenital myopathy and muscular dystrophy research that have translated into clinical treatment trials in human patients with these debilitating and often fatal conditions.
View Article and Find Full Text PDFEMBO J
December 2024
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
Int J Mol Sci
October 2024
Department of Human Genetics, Ruhr-University Bochum, 44801 Bochum, Germany.
Pathogenic variants in the ryanodine receptor 1 () gene are causative for a wide spectrum of muscular phenotypes, ranging from malignant hyperthermia over mild, non-progressive to severe congenital myopathy. Both autosomal dominant and recessive inheritance can occur, with the more severe forms usually showing recessive inheritance. However, genotype-phenotype correlations are complicated due to the large size of the gene and heterogeneous phenotypes.
View Article and Find Full Text PDFInt J Mol Sci
September 2024
Institute for Biomedical Research and Innovation, National Research Council, 87050 Mangone, Italy.
Med J Islam Repub Iran
May 2024
Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Background: Spinal muscular atrophy is an inherited neurodegenerative disorder that typically leads to severe physical disability. The present study aimed to determine the subjective evaluation of this disorder screening and analyze its influencing factors in Iran.
Methods: A cross-sectional study was performed using data from the second survey of women either pregnant or planning to become pregnant in Tehran, the capital of Iran, in 2022.