Computational Structural Biology of -nitrosylation of Cancer Targets.

Nitric oxide (NO) plays an essential role in redox signaling in normal and pathological cellular conditions. In particular, it is well known to react with cysteines by the so-called -nitrosylation reaction. -nitrosylation is a selective and reversible post-translational modification that exerts a myriad of different effects, such as the modulation of protein conformation, activity, stability, and biological interaction networks.