786 results match your criteria: "Comprehensive Health Research Centre [CHRC][Affiliation]"

Article Synopsis
  • This study investigates the link between whole exome sequencing (WES) data and clinical features in children diagnosed with type 1 diabetes before age 5, analyzing 99 unrelated cases.
  • Of the participants, 8.1% had potentially harmful rare variants in MODY genes, which were associated with specific genetic risk factors and different clinical markers compared to those without these variants.
  • The findings suggest that WES may help identify distinct subtypes (endotypes) of type 1 diabetes and pave the way for tailored treatments in young patients.
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Physical Activity and Psychosocial Outcomes in Adults with Achondroplasia: An Exploratory Study.

Int J Environ Res Public Health

August 2024

Department of Psychology, Center for Research in Education and Psychology of the University of Évora (CIEP-UE), University of Évora, 7000-727 Évora, Portugal.

Background: Adults with achondroplasia face physical and psychosocial challenges that may impact their health-related quality of life and mental health. This exploratory cross-sectional study aimed to investigate relationships between health-related quality of life, mental health, and physical activity levels in adults with achondroplasia, focusing on potential gender differences.

Methods: Sixteen adults with achondroplasia (10 women, 6 men; age 37.

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This study aimed to analyze the effect of cardiac rehabilitation programs on the health-related quality of life of patients after a coronary cardiac event using patient-reported outcome measures (PROMs) for up to 6 months of evaluation. : A comprehensive search was carried out in the MEDLINE, CINAHL, CENTRAL, and Web of Science databases for randomized controlled trials comparing the cardiac rehabilitation program with usual care. Two independent reviewers assessed the studies for inclusion, risk of bias using the Cochrane tool, and quality of evidence through the GRADE system.

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People with fibromyalgia (FM) experience a range of symptoms (chronic widespread pain, fatigue, mood disorder, sleep problems, muscle stiffness) that promote deterioration of physical condition and function. With impaired physical function, fear of falling and risk of falling increases. This study evaluated physical function, self-perceived physical fitness, falls, quality of life, and the degree of disability caused by FM according to fear and risk of falling in Spanish adult women with FM.

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Objective: The quality of the relationship between persons with dementia and family carers influences health and quality-of-life outcomes. Little is known regarding those at higher risk of experiencing a decline in relationship quality, who could potentially benefit the most from interventions. We aimed to identify these risk profiles and explore the underlying factors.

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Health literacy and its determinants among higher education students in the Alentejo region of southern Portugal-A cross-sectional survey.

PLoS One

September 2024

NOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, NOVA University Lisbon, Lisbon, Portugal.

Introduction: The capacity of higher education students to comprehend and act on health information is a pivotal factor in attaining favourable health outcomes and well-being. Assessing the health literacy of these students is essential in order to develop targeted interventions and provide informed health support. The aim of this study was to identify the level of health literacy and to analyse its relationship with determinants such as socio-demographic variables, chronic disease, perceived health status, and perceived availability of money for expenses among higher education students in the Alentejo region of southern Portugal.

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: Jump test assessment is commonly used for physical tests, with different type of devices used for its evaluation. The purpose of the present study was to examine the validity and reliability of a freely accessible mobile application (VertVision, version 2.0.

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Legacy in End-of-Life Care: A Concept Analysis.

Nurs Rep

September 2024

School of Health Sciences, Polytechnic University of Leiria, Campus 2, Morro do Lena, Alto do Vieiro, Apartado 4137, 2411-901 Leiria, Portugal.

Comprehending the significance of legacy in end-of-life (EoL) situations helps palliative care professionals enhance person-centered outcomes for those with a life-threatening illness and their families. Our purpose was to conduct a concept analysis of legacy in EoL care. By employing Walker and Avant's approach, we identified the concept's defining characteristics.

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Unlabelled: Our study aims to estimate the prevalence of depressive symptomatology among older adults and to assess their association with loneliness and quality of life according to institutionalisation status in a Portuguese sample.

Background: The World Health Organisation estimates that by 2050, the world's population over 60 will number two billion people, which poses complex challenges in terms of maintaining the mental health of older adults. The COVID-19 pandemic has increased the prevalence of depressive symptoms in this population, but the post-pandemic phase has not yet been studied much.

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The aim of the study is to assess the psychometric properties of the Portuguese version of the 18-items Dysfunctional Attitudes Scale (Form B) in a Portuguese sample of people aged 60 and over. Background: The 18-item Dysfunctional Attitudes Scale (Form B) is an instrument for assessing dysfunctional attitudes and can be useful as a predictor of depression for both initial episodes and relapses Methods: This was a one-stage cross-sectional survey of Portuguese-speaking people aged 60 years and over, able to read and write, functionally autonomous, and living in the community in their usual residences. The instrument was evaluated for its psychometric properties.

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Legislation and policy for involuntary mental healthcare across countries in the FOSTREN network: rationale, development of mapping survey and protocol.

BJPsych Open

September 2024

Health Services Research Unit (HØKH), Akershus University Hospital, Norway; Department of Mental Health Care, Faculty of Health Sciences, Oslo Metropolitan University, Norway; and Centre for Care Research, University of South-Eastern Norway, Norway.

Background: Several countries are currently revising or have already revised their mental health laws to align with the global movement to reduce the use of coercive care. No government has yet fully implemented the recommendation of the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD) to eliminate the use of coercion in mental healthcare. Consequently, the international field of mental health law and policy is in a degree of flux.

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This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of immune checkpoint inhibitors (single-agent or combination therapy) in people with advanced malignant pleural mesothelioma in a first-line or salvage setting.

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Article Synopsis
  • The text discusses a correction to a previously published article indexed under the DOI 10.3389/fgene.2022.987867.* -
  • The correction aims to address specific inaccuracies or errors found in the original study.* -
  • This update is important for maintaining the integrity of the research and ensuring accurate scientific communication.*
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Evolving Dynamics of Neck Muscle Activation Patterns in Dental Students: A Longitudinal Study.

Sensors (Basel)

September 2024

Neuromuscular Research Lab, Interdisciplinary Centre for the Study of Human Performance (CIPER), Faculty of Human Kinetics, University of Lisbon, Oeiras, 1499-002 Lisbon, Portugal.

Cervical pain has been linked to increased motor unit activity, potentially associated with the initiation and progression of chronic neck pain. Therefore, this study aimed to compare the time-course changes in cervical superficial muscle activation patterns among dental students with and without neck pain throughout their initial semester of clinical training. We used an online Nordic Musculoskeletal Questionnaire for group allocation between neck pain (NP) ( = 21) and control group (CG) ( = 23).

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Article Synopsis
  • In a study on phenylketonuria (PKU), data from 1323 patients across nine European and Turkish centers revealed that natural protein intake rises with age, especially during childhood and adolescence, while lifelong phenylalanine tolerance remains unclear.
  • The research collected dietary intake information from 2012 to 2018, showing varying tolerances among different PKU classifications, with patients having mild PKU tolerating about 50% more phenylalanine than those with classical PKU.
  • Additionally, the study highlighted that natural protein intake significantly increased for patients using sapropterin, with notable geographical differences in protein tolerance observed between Southern and Northern Europe.
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The COVID-19 pandemic significantly interrupted the grieving experiences of bereaved families and drastically changed their ways of dealing with loss. Our study aims to gain an in-depth understanding of the experience of bereaved relatives of patients who died in palliative care units during the COVID-19 pandemic. The phenomenological research design included sixteen family members of hospitalized palliative patients who died from November 2021 to June 2022.

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The second victim phenomenon: comprehensive support and systemic change in healthcare.

Int J Qual Health Care

September 2024

NOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Centre, CHRC, NOVA, University Lisbon, Lisbon, Portugal.

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Introduction: Supported accommodations (SAs) are key components of community mental health care, but little is known about residents' care pathways. This study analysed the care pathways of residents of SAs, and factors associated with their age of entry and length of stay.

Methods: A random sample of SAs' residents in Portugal was interviewed and a questionnaire was specifically developed to assess their care pathways.

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Introduction: Despite the effectiveness of exercise-based interventions on symptom management and disease progression, many people with Parkinson's Disease (PwPD) do not exercise regularly. In line with the ubiquitous use of digital health technology, the MoveONParkinson digital solution was developed, comprising a Web Platform and a Mobile App with a Conversational Agent (CA). The interface features were designed based on the principles of Social Cognitive Theory with the goal of fostering behavior change in PwPD for sustained exercise participation and improved disease management.

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Article Synopsis
  • Depression is a mental health disorder linked to poor lifestyle choices and decreased quality of life, particularly in individuals experiencing pain.
  • A study analyzed the relationship between various forms of depression and leisure-time physical activity in middle-aged and older individuals with different pain levels in Spain, using data from the European Health Survey.
  • The findings revealed that those who are physically inactive at any pain level show higher rates of depression, suggesting that increasing physical activity could help mitigate depression and its symptoms in people suffering from pain.
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Background: Longevity increases pose public health challenges, especially in managing falls and their psychological impacts on older adults. Limited evidence exists on the relationship between a fear of falling (FOF), previous falls, and depressive symptoms among community-dwelling older adults.

Objective: To evaluate the association between falls, FOF, and depressive symptoms in community-dwelling older adults.

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() promote cellular functioning by modulating NRF2-mediated antioxidant signaling. Redox failure in women with insufficiency increases the risk for breast/ovarian/uterine cancers. Risk-reducing salpingo-oophorectomy (RRSO) is a prophylactic surgery of the reproductive organs, which is frequently conducted by the age of 40 to lower the occurrence of cancer in women with mutations.

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The Knowledge Acquired by Parents in Pregnancy Monitoring Consultations.

Int J Environ Res Public Health

July 2024

Department of Nursing, Higher School of Nursing, University of Évora, 7000-811 Évora, Portugal.

(1) Pregnancy surveillance nursing consultations in the pandemic context have undergone some changes, namely the restriction of accompanying persons. In this sense, assessing the knowledge acquired by parents in pregnancy surveillance is of great importance. Since there are no studies on the subject in the period before the pandemic, we will only assess the knowledge acquired by parents in pregnancy monitoring.

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Prevalence of Lower Back Pain in Portuguese Equestrian Riders.

Sports (Basel)

July 2024

Escola de Saúde e Desenvolvimento Humano, Universidade de Évora, 7004-516 Évora, Portugal.

Lower back pain is prevalent in equestrian athletes, but its prevalence and associated factors are unknown in the Portuguese equestrian population. A questionnaire regarding lower back pain and possible associated factors was answered by 347 respondents. Of the respondents, 214 (61.

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