Dehydrogenase oxidase function: the interplay between substrate binding and flavin microenvironment.

Redox enzymes, mostly equipped with metal or organic cofactors, can vary their reactivity with oxygen by orders of magnitudes. Understanding how oxygen reactivity is controlled by the protein milieu remains an open issue with broad implications for mechanistic enzymology and enzyme design. Here, we address this problem by focusing on a widespread group of flavoenzymes that oxidize phenolic compounds derived from microbial lignin degradation, using either oxygen or a cytochrome c as electron acceptors.

Caring for people living with dementia and their informal caregivers: Current perspectives in Malaysia.

As dementia has been declared a global health crisis by the World Health Organization, this perspective paper aims to shed light on the cuerent stata of dementia care in Malaysia. The paper firsc outlinea eeveral barriers to dementia care in Malaysia. The shortage of geriatric specialists hampers the accessibility of dementia caee avd resceerces.

Iatrogenic intramural esophageal hematoma during EUS-B-FNA procedure.

Background: Esophageal ultrasound with bronchoscope fine needle aspiration (EUS-B-FNA) is a valuable tool for the diagnosis and staging of lung cancer, complementing endobronchial lung ultrasound (EBUS). While generally considered safe, there is a notable lack of comprehensive knowledge within the interventional pulmonology community regarding potential complications.

Case Presentation: We present a case involving a 66-year-old male with squamous cell lung carcinoma undergoing mediastinal staging.

Profiling the epigenome using long-read sequencing.

The advent of single-molecule, long-read sequencing (LRS) technologies by Oxford Nanopore Technologies and Pacific Biosciences has revolutionized genomics, transcriptomics and, more recently, epigenomics research. These technologies offer distinct advantages, including the direct detection of methylated DNA and simultaneous assessment of DNA sequences spanning multiple kilobases along with their modifications at the single-molecule level. This has enabled the development of new assays for analyzing chromatin states and made it possible to integrate data for DNA methylation, chromatin accessibility, transcription factor binding and histone modifications, thereby facilitating comprehensive epigenomic profiling.

Wind energy assessment and hybrid micro-grid optimization for selected regions of Saudi Arabia.

This study investigates the optimization of wind energy integration in hybrid micro grids (MGs) to address the rising demand for renewable energy, particularly in regions with limited wind potential. A comprehensive assessment of wind energy potential was conducted, and optimal sizing of standalone MGs incorporating photovoltaic (PV) systems, wind turbines (WT), and battery storage (BS) systems was performed for six regions in the Kingdom Saudi Arabia. Wind resource analysis utilizing the Weibull distribution function shows that all regions exhibited Class 1 wind energy characteristics, with average annual wind power densities ranging from 36.

Impact of declared wildfire disasters on survival of lung cancer patients undergoing radiation.

Purpose: Oncological treatments, such as radiotherapy, which requires consistent electricity, the presence of specialized clinical teams, and daily patient access to treatment facilities, are frequently disrupted by extreme weather events, posing several health hazards to patients. This study explores the association between declared wildfire disasters during radiotherapy and overall survival among patients with non-small cell lung cancer (NSCLC).

Methods: The study population consisted of 202,935 adults with inoperable Stage III NSCLC, who initiated radiotherapy from 2004 through 2019.

A Comprehensive Review of mRNA-based Vaccines for COVID-19, A New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges.

Ongoing research and development efforts are currently focused on creating COVID-19 vaccines using a variety of platforms. Among these, mRNA technology stands out as a cuttingedge method for vaccine development. There is a growing public awareness of mRNA and its potential in vaccine development.

Deciphering the Evolution of Current Distribution in Hybrid Silver Vanadium Oxide / Carbon Monofluoride Cathodes within Lithium Primary Batteries.

For batteries to function effectively all active material must be accessible requiring both electron and ion transport to each particle. A common approach to generating the needed conductive network is the addition of carbon. An alternative approach is the electrochemically induced formation of conductive reaction products generated with intimate contact to the active material.

Immunoregulatory programs in anti-N-methyl-D-aspartate receptor encephalitis identified by single-cell multi-omics analysis.

Background: Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a prevalent type of autoimmune encephalitis caused by antibodies targeting the NMDAR's GluN1 subunit. While significant progress has been made in elucidating the pathophysiology of autoimmune diseases, the immunological mechanisms underlying anti-NMDARE remain elusive. This study aimed to characterize immune cell interactions and dysregulation in anti-NMDARE by leveraging single-cell multi-omics sequencing technologies.

Prospective association of tobacco retailer density and neighbourhood walkability with youth vaping initiation in California, USA.

Background: Tobacco retailer density might influence youth e-cigarette use due to increased access and exposure to point-of-sale marketing. There is a need for longitudinal investigations on the association of tobacco retailer density with youth e-cigarette use, with consideration of contextual factors such as neighbourhood walkability that could enhance retailer exposure.

Methods: Five semi-annual waves (Fall 2021-Fall 2023) of a Southern California school-based cohort of youth who never vaped at baseline (n=3401; mean baseline age=15 years [range=12-17]) were merged with spatial data on tobacco retailers corresponding to each school year.

Determinants of knowledge of preconception care among healthcare providers in Ethiopia: a systematic review and meta-analysis.

Objective: To assess the determinants of knowledge of preconception care (PCC) among healthcare providers in Ethiopia.

Design: Systematic review and meta-analysis.

Data Source: Comprehensive literature searches were conducted in PubMed, Scopus and Health Internetwork Access to Research Initiative (HINARI) published until 20 March 2024.

Do continuous glucose monitoring (CGM) metrics predict macrovascular and microvascular complications in diabetes? The FACULTY protocol of a retrospective real-world cohort study.

Introduction: Glycated haemoglobin (HbA1c) is currently the gold standard for assessing glycaemic control in diabetes, given the established relationship with microvascular and macrovascular complications in this condition. However, HbA1c is affected by non-glycaemic factors, while also failing to provide data on hypoglycaemic exposure and glucose variability, which are associated with adverse vascular outcomes. Continuous glucose monitoring (CGM)-derived glucose metrics provide a more comprehensive assessment of glycaemia, but their role in predicting future vascular complications remains unclear.

Fractionation of pequi pulp oil and modeling by thermodynamic phase equilibrium theory.

This study focused on evaluating the fractionation of pequi oil and modeling the process using solid-liquid equilibrium (SLE) theory. The pequi oil was comprehensively characterized, including its fatty acid (FA) and acylglycerol (AG) profiles, moisture content, acidity, carotenoid levels, and thermal behavior. Low acidity and partial acylglycerols content, along with its TAG profile (mainly OOP, POP, OOO and PPP) and melting behavior proved that, in fact, this oil is quite suitable for fractionation.

Prevalence and Determinants of Sensitisation to Neomycin in North-Eastern Italy, 1997-2021.

Background: Allergic contact dermatitis (ACD) induced by topical application of neomycin is frequently reported.

Objectives: This multi-center study investigated prevalence and determinants of neomycin sensitisations in 30 629 outpatients from North-eastern Italy during 1997-2021.

Patients And Methods: European baseline and extended Triveneto series were applied on the upper back of patients patch testing for suspected ACD and removed after 48 h.

An emotionally intelligent haptic system - An efficient solution for anxiety detection and mitigation.

Background: Anxiety is a psycho-physiological condition associated with an individual's mental state. Long-term anxiety persistence can lead to anxiety disorder, which is the underlying cause of many mental health problems. As such, it is critical to precisely identify anxiety by automated, effective, and user-bias-free ways.

Prediction of mortality in intensive care unit with short-term heart rate variability: Machine learning-based analysis of the MIMIC-III database.

Background: Prognosis prediction in the intensive care unit (ICU) traditionally relied on physiological scoring systems based on clinical indicators at admission. Electrocardiogram (ECG) provides easily accessible information, with heart rate variability (HRV) derived from ECG showing prognostic value. However, few studies have conducted a comprehensive analysis of HRV-based prognostic model against established standards, which limits the application of HRV's prognostic value in clinical settings.

A Novel Approach to Research Synthesis with the Distillation and Matching Model: Application to the Prevention of Youth Social, Emotional, and Behavioral Problems.

It is difficult for consumers to access the evidence base for prevention programs to determine which models or practices have the strongest empirical support for improving youth social, emotional, and behavioral (SEB) outcomes within their specific service contexts. Researchers can address this evidence-to-practice gap through innovations in research synthesis. The Distillation and Matching Model (Chorpita et al.

Evaluating postoperative complications in standard percutaneous nephrolithotomy for renal stones larger than 2 cm: a retrospective study utilizing the E-PASS scoring system.

Percutaneous nephrolithotomy (PCNL) is a widely preferred method for treating complex kidney stones, particularly in patients with larger or more complicated stones. Despite its advantages, such as minimal invasiveness and a shorter recovery time, postoperative complications can occur, thereby necessitating effective risk assessment tools to identify at-risk patients. This study evaluated the Estimation of Physiologic Ability and Surgical Stress (E-PASS) scoring system's utility in predicting postoperative complications following standard PCNL.

Educational Needs of Informal Caregivers in Cardiac Rehabilitation: a Mixed-Methods Study.

Aim: Informal caregivers play a crucial role in supporting individuals with cardiovascular disease (CVD) during cardiac rehabilitation (CR), yet their specific educational needs are often overlooked. Understanding these needs is essential for developing targeted interventions that enhance informal caregiver support and improve patient outcomes in CR. This study aimed to explore the educational needs of informal caregivers supporting individuals with CVD attending CR.

Improving readability in AI-generated medical information on fragility fractures: the role of prompt wording on ChatGPT's responses.

Unlabelled: Understanding how the questions used when interacting with chatbots impact the readability of the generated text is essential for effective health communication. Using descriptive queries instead of just keywords during interaction with ChatGPT results in more readable and understandable answers about fragility fractures.

Purpose: Large language models like ChatGPT can enhance patients' understanding of medical information, making health decisions more accessible.

The Impact of Being Present During Resuscitation on Family Members: A Scoping Review Protocol.

Background And Aims: Family members of patients who are undergoing resuscitation may experience complex psychological challenges, including anxiety, depression, or posttraumatic stress symptoms. Although several studies have identified positive experiences of family members who were given the option to be present during their loved one's resuscitation, the actual impact of family presence during resuscitation on family members remains elusive and needs to be explored comprehensively. This review aims to identify the impact of being present during the resuscitation event of adult patients in in-hospital settings on family members.

Toward Resilient Maternal, Neonatal and Child Health Care: A Qualitative Study Involving Afghan Refugee Women in Pakistan.

Background: Afghan refugees in Pakistan, particularly in Quetta, Balochistan, encounter formidable barriers in accessing maternal, newborn, and child health (MNCH) services. These challenges have been intensified by the COVID-19 pandemic and entrenched systemic health inequities.

Methods: This qualitative study, conducted from February to April 2023, aimed to assess the obstacles within health systems and community environments that hinder MNCH service access among Afghan refugees.

Opportunities and barriers for reimbursement of digital therapeutics in Austria: Findings From expert interviews.

Background: Digital therapeutics (DTx) are software-based interventions that aim to prevent or treat especially non-communicable diseases. Currently, no framework for reimbursement of DTx exists in Austria. The aim of this study was to gather a comprehensive perspective on regulatory considerations of Austrian stakeholders with regard to reimbursement of DTx and to outline strategies for establishing a national reimbursement framework.

Occupational health professionals' and HR specialists' perceptions of telemental health services in occupational health care settings: A qualitative study.

Objective: The rise in mental health-related work disability pensions highlights the need for more research on how occupational health care (OHC) can support mental health, including the use of telehealth (TH) services in mental health care.

Methods: The research, employing a descriptive qualitative approach through interviews ( = 42), focused on experiences of professionals from a private OHC service provider in Finland and human resource representatives (HRRs) of OHC client companies. Inductive content analysis was used to analyze the data.

Meta-Analysis: Prevalence of Youth Mental Disorders in Sub-Saharan Africa.

Youth in sub-Saharan Africa (SSA) face limited access to professional mental health resources. A comprehensive assessment of the prevalence of mental disorders would build an understanding of the scope of the need. We conducted systematic searches in PsycInfo, Pubmed, AfriBib and Africa Journals Online to identify prevalence rates for five disorders (anxiety, depression, conduct disorder, attention problems and post-traumatic stress) among SSA youth with a mean age of less than 19 years.