44,166 results match your criteria: "Comprehensive Access & Delivery Research and Evaluation (CADRE) Center[Affiliation]"

Background: Electronic health records (EHRs) facilitate the accessibility and sharing of patient data among various health care providers, contributing to more coordinated and efficient care.

Objective: This study aimed to summarize the evolution of secondary use of EHRs and their interoperability in medical research over the past 25 years.

Methods: We conducted an extensive literature search in the PubMed, Scopus, and Web of Science databases using the keywords Electronic health record and Electronic medical record in the title or abstract and Medical research in all fields from 2000 to 2024.

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Background: The mental health crisis among college students intensified amid the COVID-19 pandemic, suggesting an urgent need for innovative solutions to support them. Previous efforts to address mental health concerns have been constrained, often due to the underuse or shortage of services. Mobile health (mHealth) technology holds significant potential for providing resilience-building support and enhancing access to mental health care.

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Background: The Wound Care Collaborative Community (WCCC) assesses shortcomings and unmet needs in wound care by partnering with key stakeholders, such as the National Institutes of Health, the US Food and Drug Administration (FDA), industry leaders, and expert health care providers and researchers, to advance the study of wound healing. Through this work, the WCCC has identified a few key barriers to innovation in wound care. The WCCC aims to accelerate the development of science-based, patient-centered solutions and address public policy challenges related to ensuring patients receive early access to innovative treatment options.

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Moving toward universal health coverage with a national health insurance program: A scoping review and narrative synthesis of experiences in eleven low- and lower-middle income countries.

PLOS Glob Public Health

January 2025

Health, Nutrition & Population Global Practice, The World Bank Group, Washington, District of Columbia, United States of America.

Universal Health Coverage (UHC) aims to provide access to quality health services to all while avoiding financial hardship. Strategies can include establishing a national health insurance scheme (NHIS). However, variations in the progress exist among countries with an NHIS.

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Breastfeeding (BF) is vital for maternal and infant health, yet post-hospital discharge support remains a challenge. The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides BF peer counseling prenatally and up to 1-year postpartum among low-income women in the United States. The Lactation Advice Through Texting Can Help (LATCH) intervention is an evidence-based two-way text messaging intervention that provides BF education and support in the WIC peer counseling program.

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The direct incorporation of borondipyrromethene (BODIPY) subunits into the structural backbone of covalent organic frameworks (COFs) gives facile access to porous photosensitizers but is still a challenging task. Here, we introduce β‑ketoenamine-linked BDP‑TFP‑COF, which crystallizes in AA‑stacking mode with hcb topology. A comprehensive characterization reveals high crystallinity and enhanced stability in a variety of solvents, excellent mesoporosity (SABET = 1042 m2 g-1), broad light absorption in the visible region, and red emission upon the exfoliation of few-layer COF nanosheets.

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As mental health needs rise, creative and timely solutions are essential. Leveraging the expansion and flexibility of virtual services to create telehealth and hybrid offerings is crucial for addressing systemic barriers in mental health, enhancing accessibility, and providing flexible, comprehensive care options for diverse patient populations. This article discusses the development of a mental health urgent care program within a large medical system in a densely populated, under-resourced community.

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Objectives: This study accessed the challenges with financing cardiothoracic surgical care in Africa, highlighting the present state of funding, and proffering probable solutions to adequate and effective funding in the region.

Methods: Through a literature review, the authors elaborate on key points such as; areas of financial funding in cardiothoracic surgery, barriers to appropriate allocation of financial resources for cardiothoracic surgery in Africa, and the needs and available resources for cardiothoracic surgery in Africa. Multiple search engines and databases were used, like: PubMed, Medline, Cochrane, Scopus, and Google Scholar.

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Background: Natural language processing (NLP) and machine learning (ML) techniques may help harness unstructured free-text electronic health record (EHR) data to detect adverse drug events (ADEs) and thus improve pharmacovigilance. However, evidence of their real-world effectiveness remains unclear.

Objective: To summarise the evidence on the effectiveness of NLP/ML in detecting ADEs from unstructured EHR data and ultimately improve pharmacovigilance in comparison to other data sources.

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Background: The Knight Alzheimer Research Imaging (KARI) dataset, a compilation of data from projects conducted at Washington University in St. Louis, represents a comprehensive effort to advance our understanding of Alzheimer disease (AD) through multimodal data collection. The overarching goal is to characterize normal aging and disease progression to contribute insights into the biological changes preceding AD symptom onset.

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Background: A key characteristic of Alzheimer's disease (AD) is cerebral aggregation of tau. These aggregates can be quantified and localized with positron emission tomography (PET), which improves the diagnostic and prognostic work-up of AD. However, tau-PET is expensive and not available in clinical settings globally.

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Biomarkers.

Alzheimers Dement

December 2024

Memory and Aging Center, UCSF Weill Institute for Neurosciences, San Francisco, CA, USA.

Background: Early onset dementia (EOD) affects people at the peak of their personal and professional responsibilities and economic productivity. Alzheimer's disease (AD) and Frontotemporal Dementia (FTD) are the most common EOD etiologies in Non-Latinx White adults (NLW). Black and Latinx older adults bear a disproportionate burden of dementia compared to NLW, likely due to vulnerabilities that confer increased risk, such as cardiovascular factors, socioeconomic stressors, and structural racism.

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Background: Recent technological advancements have revolutionized our approach to healthcare, enabling us to harness the potential of smartphones and wearables to collect data that can be used to characterize Alzheimer's disease (AD) heterogeneity and to develop digital biomarkers. Our focus is to create comprehensive cross-domain digital datasets and establish an infrastructure that allows for seamless data sharing. Central to accelerating the potential of digital biomarkers for more accurate and early detection is privacy-protecting data access, which when combined with deep molecular phenotyping, will enhance our understanding of the biological mechanisms underlying clinical expression.

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Background: Spontaneous speech is easily obtainable and has the potential to become an accessible and low-cost marker for cognitive function. The time-consuming and labor-intensive nature of speech analysis has been a major obstacle to utilizing this promising tool. This study uses a novel transformer-based methodology to explore associations between spontaneous speech language features and global cognition.

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Background: Global health is increasingly burdened by oral diseases (ODs) affecting 3.9 billion people, and Alzheimer's disease with related dementias (AD/ADRD), impacting 46.8 million globally.

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Background: Alzheimer's disease and related dementias (ADRD) place enormous burdens on families, care partners, and the public programs that finance ADRD services. Caregiving is disproportionately provided by women, individuals of low socioeconomic status, and underserved minority populations, who also rely upon informal care and support. National dementia strategies rarely address the needs of care partners.

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Background: Due to declining birthrate and increasing longevity, the number of older people living alone with cognitive impairment is rapidly increasing in Japan. They have a lot of challenges in terms of health, housing, finance, daily life and protection of rights, all of which should be clarified to create inclusive, equitable, and sustainable super-aged societies.

Methods: A series of factual investigation was conducted using existing statical materials, community-based epidemiological studies, clinic-based case studies, and literature reviews.

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Background: The outcomes of extensive Genome-Wide Association Study (GWAS) data in Polygenic Risk Score (PRS) studies exhibit varying odds ratios (ORs), ranging from 1.13 (Bellenguez) to 1.34 (Kunkle).

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Background: Numerous social factors, including socioeconomic status, education, and healthcare access, influence health outcomes in older adults. Despite the potential clinical utility of assessing social vulnerability, it is not routinely evaluated in clinical assessments of older adults. This study aims to investigate the association between cognitive decline and a comprehensive social vulnerability index, defined as an index comprising many social factors such as income, education, and housing tenure.

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Public Health.

Alzheimers Dement

December 2024

CRONICAS, Universidad Peruana Cayetano Heredia, Lima, Peru.

Background: Dementia is a global health challenge, especially in low- and middle-income countries like Peru, where diagnosis, access, and awareness are limited. Within the IMPACT Dementia project, a component focuses on developing, testing, and implementing an mHealth-enabled system for dementia screening and diagnosis, and assessing its cost-effectiveness.

Methods: Phase I.

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Public Health.

Alzheimers Dement

December 2024

Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Background: Dementia prevalence in Latin America is higher in rural than urban areas. This discrepancy may be explained by inequities over the lifespan in access to health and educational services. However, there is no evidence of potential adverse long-standing effects of living in rural areas during childhood in current urban adults.

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Background: Plasma biomarker development is of increasing interest due to improved accessibility compared to established diagnostic modalities for Alzheimer's disease (AD). However, current plasma biomarker candidates have not been tested comprehensively in diverse populations, and these markers represent only a fraction of pathways perturbed in AD. Therefore, there is a need to identify novel plasma biomarkers that account for both disease heterogeneity and patient diversity.

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Biomarkers.

Alzheimers Dement

December 2024

Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.

Background: Predicting Alzheimer's disease (AD) and frontotemporal dementia (FTD) using polygenic risk scores (PRS) for late-onset forms holds promise, but its accuracy might be influenced by social determinants of health (SDOH). This study explores how considering SDOH alongside genes can improve prediction, focusing on potential differences for each disease.

Methods: Employing logistic regression in 677 individuals (287 AD, 102 FTD, and 288 controls) aged 40-80 from the ReDLat study across six Latin American countries, we investigated the potential for SDOH to modify the association between PRS and susceptibility to AD and FTD.

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Biomarkers.

Alzheimers Dement

December 2024

SPEAR BIO INC, Woburn, MA, USA.

Background: Cutting-edge ultrasensitive immunoassay platforms have unveiled the potential of blood-based biomarkers, offering detection at low fg/mL levels for early neurodegenerative disorder prognosis, screening, and therapeutic monitoring. Current immunoassays, such as single molecule array (SIMOA) and mesoscale multi-array (MSD), face limited adoption due to their reliance on specialized equipment. Additionally, they require immobilization of probe reagents and a washing process, demanding tens of thousands of proteins to achieve the Limit of Detection (LOD), leading to the requirement of high sample volume and high affinity antibodies for fg/mL sensitivity.

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Biomarkers.

Alzheimers Dement

December 2024

Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montréal, QC, Canada.

Background: Timely and non-invasive prediction of amyloid status are pivotal in Alzheimer's disease (AD) diagnostics. This research leverages T1 MRI images to predict amyloid positivity or negativity, offering an economical and less invasive alternative to amyloid PET scans. Using the comprehensive TRAID dataset from McGill University, the study evaluates a spectrum of cognitive conditions including AD, atypical AD, Cognitively Normal (CN), Mild Cognitive Impairment (MCI), MCI not due to AD, Suspected Non-Alzheimer's Pathophysiology (SNAP), and Vascular MCI (VMCI).

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