Axion Field Influence on Josephson Junction Quasipotential.

The direct effect of an axion field on Josephson junctions is analyzed through the consequences on the effective potential barrier that prevents the junction from switching from the superconducting to the finite-voltage state. We describe a method to reliably compute the quasipotential with stochastic simulations, which allows for the spanning of the coupling parameter from weakly interacting axion to tight interactions. As a result, we obtain an axion field that induces a change in the potential barrier, therefore determining a significant detectable effect for such a kind of elusive particle.

Novel GH109 enzymes for bioconversion of group A red blood cells to the universal donor group O.

Glycoside hydrolases (GHs) have been employed for industrial and biotechnological purposes and often play an important role in new applications. The red blood cell (RBC) antigen system depends on the composition of oligosaccharides on the surface of erythrocytes, thus defining the ABO blood type classification. Incorrect blood transfusions may lead to fatal consequences, making the availability of the correct blood group critical.

Experimental assessment of nuclear cross sections for the production of Tb radioisotopes with a medical cyclotron.

Tb is one of the most interesting radionuclides for theranostic applications. It is suitable for SPECT imaging and it can be used as a true diagnostic partner of the therapeutic Tb and Tb. Its production by proton irradiation using enriched Gd and Gd oxide targets is currently being investigated and represents a promising solution.

First Direct Observation of Collider Neutrinos with FASER at the LHC.

We report the first direct observation of neutrino interactions at a particle collider experiment. Neutrino candidate events are identified in a 13.6 TeV center-of-mass energy pp collision dataset of 35.

Impact of prepubertal bovine ovarian tissue pre-freeze holding duration on follicle quality.

Ovarian tissue cryopreservation prior to gonadotoxic treatment is the only recommended option for fertility preservation in prepubertal girls. Due to the technical complexity of this technique, limited number of centres across the world are equipped to offer the facility. Hence, the retrieved ovarian tissue needs to be maintained at hypothermic temperature (4 °C) for long time during shipment.

Cross-section measurement of thulium radioisotopes with an 18 MeV medical PET cyclotron for an optimized Er production.

Er is a pure Auger-electron emitter with promising characteristics for therapeutic applications in nuclear medicine. The short penetration path and high Linear Energy Transfer (LET) of the emitted Auger electrons make Er particularly suitable for treating small tumor metastases. Several production methods based on the irradiation with charged particles of Er and Ho targets can be found in the literature.

Glycoside hydrolases from (hyper)thermophilic archaea: structure, function, and applications.

(Hyper)thermophilic archaeal glycosidases are enzymes that catalyze the hydrolysis of glycosidic bonds to break down complex sugars and polysaccharides at high temperatures. These enzymes have an unique structure that allows them to remain stable and functional in extreme environments such as hot springs and hydrothermal vents. This review provides an overview of the current knowledge and milestones on the structures and functions of (hyper)thermophilic archaeal glycosidases and their potential applications in various fields.

Signatures of Dissipation Driven Quantum Phase Transition in Rabi Model.

By using the worldline Monte Carlo technique, matrix product state, and a variational approach à la Feynman, we investigate the equilibrium properties and relaxation features of the dissipative quantum Rabi model, where a two level system is coupled to a linear harmonic oscillator embedded in a viscous fluid. We show that, in the Ohmic regime, a Beretzinski-Kosterlitz-Thouless quantum phase transition occurs by varying the coupling strength between the two level system and the oscillator. This is a nonperturbative result, occurring even for extremely low dissipation magnitude.

Multiple Scattering Expansion for Dielectric Media: Casimir Effect.

Recent measurements of Casimir forces have provided evidence of an intricate modification of quantum fluctuations of the electromagnetic field in complex geometries. Here we introduce a multiple scattering description for Casimir interactions between bodies of arbitrary shape and material composition, admitting an expansion as a sequence of inter- and intra-body wave scatterings. Interactions in complex geometries can be computed within the current experimental resolution from typically a few wave scatterings, notably without any a priori knowledge of the scattering amplitudes of the bodies.

Insulin Activation Mediated by Uptake Mechanisms: A Comparison of the Behavior between Polymer Nanoparticles and Extracellular Vesicles in 3D Liver Tissues.

In this work, we compare the role of two different uptake mechanisms in the effectiveness of a nanoformulated drug, specifically insulin. Insulin is activated by interacting with insulin receptors exposed on the liver cell membrane that triggers the uptake and storage of glucose. To prove that the uptake mechanism of a delivery system can interfere directly with the effectiveness of the delivered drug, two extremely different delivery systems are tested.

Periodic Surface Structuring of Copper with Spherical and Cylindrical Lenses.

The use of a cylindrical lens in femtosecond laser surface structuring is receiving attention to improve the processing efficiency. Here, we investigate the structures produced on a copper target, in air, by exploiting both spherical and cylindrical lenses for beam focusing, aiming at elucidating similarities and differences of the two approaches. The morphological features of the surface structures generated by ≈180 fs laser pulses at 1030 nm over areas of 8 × 8 mm were analyzed.

Optimized production of Cu based on cross section measurements of Cu and Cu using an 18 MeV medical cyclotron.

RadioNuclide Therapy (RNT) in nuclear medicine is a cancer treatment based on the administration of radioactive substances that specifically target cancer cells in the patient. These radiopharmaceuticals consist of tumor-targeting vectors labeled with β, α, or Auger electron-emitting radionuclides. In this framework, Cu is receiving increasing interest as it provides β-particles accompanied by low-energy γ radiation.

Selective Targeting of Cancer-Related G-Quadruplex Structures by the Natural Compound Dicentrine.

Aiming to identify highly effective and selective G-quadruplex ligands as anticancer candidates, five natural compounds were investigated here, i.e., the alkaloids Canadine, D-Glaucine and Dicentrine, as well as the flavonoids Deguelin and Millettone, selected as analogs of compounds previously identified as promising G-quadruplex-targeting ligands.

First post-Newtonian -body problem in Einstein-Cartan theory with the Weyssenhoff fluid: Lagrangian and first integrals.

The rotational dynamics of an -body system at the first post-Newtonian order in Einstein-Cartan theory is derived. This result is achieved by performing the point-particle limit of the equations of motion of the Weyssenhoff fluid, which models the quantum spin effects residing inside the bodies. For the special case of binary systems, we determine the Lagrangian function and the resulting first integrals underlying the translational dynamics and the spin precession.

Impact of Hydrophobic Chains in Five-Coordinate Glucoconjugate Pt(II) Anticancer Agents.

This study describes new platinum(II) cationic five-coordinate complexes () of the formula [PtR(NHC)(dmphen)(ethene)]CFSO (dmphen = 2,9-dimethyl-1,10-phenanthroline), containing in their axial positions an alkyl group R (methyl or octyl) and an imidazole-based NHC-carbene ligand with a substituent R' of variable length (methyl or octyl) on one nitrogen atom. The Pt-carbene bond is stable both in DMSO and in aqueous solvents. In DMSO, a gradual substitution of dmphen and ethene is observed, with the formation of a square planar solvated species.

Nature of the Ultrafast Interligands Electron Transfers in Dye-Sensitized Solar Cells.

Charge-transfer dynamics and interligand electron transfer (ILET) phenomena play a pivotal role in dye-sensitizers, mostly represented by the Ru-based polypyridyl complexes, for TiO and ZnO-based solar cells. Starting from metal-to-ligand charge-transfer (MLCT) excited states, charge dynamics and ILET can influence the overall device efficiency. In this letter, we focus on N3 dye ( [Ru(dcbpy)(NCS)], dcbpy = 4,4'-dicarboxy-2,2'-bipyridine) to provide a first direct observation with high time resolution (<20 fs) of the ultrafast electron exchange between bpy-like ligands.

A -Adic Model of Quantum States and the -Adic Qubit.

We propose a model of a quantum N-dimensional system (quNit) based on a quadratic extension of the non-Archimedean field of -adic numbers. As in the standard complex setting, states and observables of a -adic quantum system are implemented by suitable linear operators in a -adic Hilbert space. In particular, owing to the distinguishing features of -adic probability theory, the states of an N-dimensional -adic quantum system are implemented by -adic statistical operators, i.

Archaea as a Model System for Molecular Biology and Biotechnology.

Archaea represents the third domain of life, displaying a closer relationship with eukaryotes than bacteria. These microorganisms are valuable model systems for molecular biology and biotechnology. In fact, nowadays, methanogens, halophiles, thermophilic euryarchaeota, and crenarchaeota are the four groups of archaea for which genetic systems have been well established, making them suitable as model systems and allowing for the increasing study of archaeal genes' functions.

Understanding Charge Dynamics in Dense Electronic Manifolds in Complex Environments.

Photoinduced charge transfer (CT) excited states and their relaxation mechanisms can be highly interdependent on the environment effects and the consequent changes in the electronic density. Providing a molecular interpretation of the ultrafast (subpicosecond) interplay between initial photoexcited states in such dense electronic manifolds in condensed phase is crucial for improving and understanding such phenomena. Real-time time-dependent density functional theory is here the method of choice to observe the charge density, explicitly propagated in an ultrafast time domain, along with all time-dependent properties that can be easily extracted from it.

Geodesic motion in Euclidean Schwarzschild geometry.

This paper performs a systematic investigation of geodesic motion in Euclidean Schwarzschild geometry, which is studied in the equatorial plane. The explicit form of geodesic motion is obtained in terms of incomplete elliptic integrals of first, second and third kind. No elliptic-like orbits exist in Euclidean Schwarzschild geometry, unlike the corresponding Lorentzian pattern.

Observation of Rayleigh-Lamb waves generated by the 2022 Hunga-Tonga volcanic eruption with the POLA detectors at Ny-Ålesund.

The eruption of the Hunga-Tonga volcano in the South Pacific Ocean on January 15, 2022, at about 4:15 UTC, generated a violent explosion, which created atmospheric pressure disturbances in the form of Rayleigh-Lamb waves detected all over the globe. Here we discuss the observation of the Hunga-Tonga shock-wave performed at the Ny-Ålesund Research Station on the Spitsbergen island, by the detectors of the PolarquEEEst experiment and their ancillary sensors. Online pressure data as well as the results of dedicated offline analysis are presented and discussed in details.

Alternative routes for Cu production using an 18 MeV medical cyclotron in view of theranostic applications.

Radiometals play a fundamental role in the development of personalized nuclear medicine. In particular, copper radioisotopes are attracting increasing interest since they offer a varying range of decay modes and half-lives and can be used for imaging (Cu, Cu, Cu and Cu) and targeted radionuclide therapy (Cu and Cu), providing two of the most promising true theranostic pairs, namely Cu/Cu and Cu/Cu. Currently, the most widely used in clinical applications is Cu, which has a unique decay scheme featuring β-, β-decay and electron capture.

New physics searches at kaon and hyperon factories.

Rare meson decays are among the most sensitive probes of both heavy and light new physics. Among them, new physics searches using kaons benefit from their small total decay widths and the availability of very large datasets. On the other hand, useful complementary information is provided by hyperon decay measurements.