A predictive model of neurodegeneration in idiopathic REM-sleep behavior disorder.

Objective: To investigate whether Parkinson's disease (PD) and dementia are competing risks in subjects with idiopathic rapid-eye-movement sleep behavior disorder (RBD).

Methods: The number of incidental PD cases observed in 11 longitudinal RBD studies was compared with the corresponding expected number as estimated by a simple mathematical model based on population parameters for PD age-of-onset.

Results: The expected number of incidental PD cases exceeded observed PD cases (p-value < 0.

Impact of non-motor symptoms on health-related and perceived quality of life in Parkinson's disease.

Objective: To investigate the impact of non-motor symptoms on health-related and perceived quality of life in Parkinson's disease (PD).

Methods: One hundred and fifty PD patients (57.3% males; 70.

Imaging of Dopamine in PD and Implications for Motor and Neuropsychiatric Manifestations of PD.

Parkinson's disease (PD) is characterized by dopamine depletion in the putamen, which leads to motor dysfunction. As the disease progresses, a substantial degree of dopamine depletion also occurs in caudate and nucleus accumbens. This may explain a number of neuropsychiatric manifestations, including depression, apathy, and cognitive decline.