Clinical Study on the Effects of Total Hip Arthroplasty Assisted by Virtual Planning Combined With Intraoperative Navigation Templates.

Objectives: Although total hip arthroplasty (THA) effectively alleviates pain and restores joint function in the end-stage hip disease, challenges remain in achieving precise osteotomy and minimizing subjective dependency on prosthesis positioning. This study aims to evaluate the efficacy and safety of preoperative virtual planning and navigation templates compared to conventional techniques, providing new methods to enhance the precision and personalization of THA.

Methods: During the period from 2022 to 2023, we conducted a retrospective case-control study on 74 patients who underwent THA surgery at our hospital, based on the inclusion and exclusion criteria.

Effect of the Appended Morpholinyl Group on Photophysical Behavior of Mono- and Bis-cyclometalated Terpyridine Iridium(III) Chromophores.

This paper provides extensive studies of [IrCl(Ph-py)(morph-CH-terpy-κN)]PF (), [Ir(Ph-py)(morph-CH-terpy-κN)]PF (), [IrCl(Ph-py)(Ph-terpy-κN)]PF (), and [Ir(Ph-py)(Ph-terpy-κN)]PF () designed to demonstrate the possibility of controlling the photophysical properties of mono- and bis-cyclometalated complexes [IrCl(Ph-py)(R-CH-terpy-κN)]PF and [Ir(Ph-py)(R-CH-terpy-κN)]PF through a remote electron-donating substituent introduced into the 4'-position of 2,2':6',2″-terpyridine (terpy) via the phenyl linker. The attachment of the morpholinyl (morph) group was evidenced to induce dramatic changes in the emission characteristics of the monocyclometalated Ir(III) systems with coordinated R-CH-terpy ligand (κN). In solution, the obtained complex [IrCl(Ph-py)(morph-CH-terpy-κN)]PF was found to be a rare example of dual-emissive Ir(III) systems.

[Parameter estimation using time-dependent Weibull proportional hazards model for survival analysis with partly interval censored data].

: To assess the validity and effectiveness of parameter estimation using a time-dependent Weibull proportional hazards model for survival analysis containing partly interval censored data and explore the impact of different covariates on the results of analysis. : We established a time-dependent Weibull proportional hazards model using the Weibull distribution as the baseline hazard function of the model which incorporated time-varying covariates. Maximum likelihood estimation was employed to estimate the model parameters, which were obtained by optimization of the likelihood function.

Circadian Regulation of the Rice Immune Response during Rice Blast Infection via Metabolic and Calcium Signaling.

The circadian clock is crucial in plant immunity and metabolism, yet the coordinating mechanisms remain elusive. In the present study, transcriptome analysis of -infected rice leaves and rhythmic analysis showed reduced amplitudes of circadian and phytochrome genes, impacting immune response, metabolic pathways, and calcium signaling. The amplitudes of pattern-triggered immunity (PTI)-related genes declined, while the rhythmicity of effector-triggered immunity (ETI)-related genes disappeared.

Functional and Structural Improvement of Engineered Cardiac Microtissue Using Aligned Microfilaments Scaffold.

To enhance therapeutic strategies for cardiovascular diseases, the development of more reliable in vitro preclinical systems is imperative. These models, crucial for disease modeling and drug testing, must accurately replicate the 3D architecture of native heart tissue. In this study, we engineered a scaffold with aligned poly(lactic--glycolic acid) (PLGA) microfilaments to induce cellular alignment in the engineered cardiac microtissue (ECMT).

Intelligent Gesture Recognition Gloves for Real-Time Monitoring in Wireless Human-Computer Interaction.

Flexible sensors mimic the sensing ability of human skin, and have unique flexibility and adaptability, allowing users to interact with intelligent systems in a more natural and intimate way. To overcome the issues of low sensitivity and limited operating range of flexible strain sensors, this study presents a highly innovative preparation method to develop a conductive elastomeric sensor with a cracked thin film by combining polydimethylsiloxane (PDMS) with multiwalled carbon nanotubes (MCNT). This novel design significantly increases both the sensitivity and operating range of the sensor (strain range 0-50%; the maximum tensile sensitivity of this sensor reaches 4.

Nicotine increases hepatocyte transthyretin turnover: a possible mechanism for the protective effect of smoking on preeclampsia?

Transthyretin is a thyroid hormone binding protein with a major role in the distribution of thyroid hormones to peripheral tissues. In preeclampsia, the failing placenta releases soluble endoglin into the maternal circulation causing systemic vascular dysfunction. Our group has previously shown that transthyretin binds to soluble endoglin and is taken up as a complex into hepatocytes.

Quantifying the impact of metronomic chemotherapy chemo-switch regimen and the sequencing of chemotherapy and radiotherapy on pancreatic ductal adenocarcinoma treatment.

Metronomic chemotherapy (MCT) is a novel chemotherapy approach characterized by a high-frequency, low-dose administration strategy. The "chemo-switch" regimen involves the sequential use of two dosing strategies: maximum tolerated dose (MTD) chemotherapy and MCT. For patients with pancreatic ductal adenocarcinoma (PDAC), selecting novel chemotherapy regimens appropriately according to their physical conditions may help address the challenges associated with MTD chemotherapy, such as excessive toxicity, prolonged tumor recovery, and suboptimal efficacy.

KCNJ15 inhibits chemical-induced lung carcinogenesis and progression through GNB1 mediated Hippo pathway.

Polycyclic aromatic hydrocarbons (PAHs) have been regarded as important environmental carcinogens that can cause lung cancer. However, the underlying epigenetic mechanism during PAHs-induced lung carcinogenesis has remained largely unknown. Previously, we screened some novel epigenetic regulatory genes during 3-methylcholanthrene (3-MCA)-induced lung carcinogenesis, including the potassium inwardly rectifying channel subfamily J member 15 (KCNJ15) gene.

A Study on the Treatment of Rheumatoid Arthritis with Lipid Nanoparticles Containing mRNA encoding Heat shock protein 10.

In order to delay the progression of Rheumatoid Arthritis (RA) in patients, and to prevent further teratogenesis and irreversible bone erosion through drug intervention in the early stages of inflammation, this experiment used the mRNA encoding heat shock protein 10 (HSP10) (H-mRNA) as the main therapeutic drug and used Microfluidics technology to prepare lipid nanoparticles (LNP) (H-mRNA LNPs) containing H-mRNA, and the surface of H-mRNA-LNPs was modified using heparin particals to obtain the final formulation H-mRNA-LNPs @ heparin/ Protamine. Through the sequence modification and effect evaluation of H-mRNA, we explored the formulation screening, physical characterization, cytotoxicity in vitro, distribution in vivo, pharmacodynamics in vivo, and safety in vivo of the prepared lipid nanoparticles, which proved that this nano-preparation had good anti Rheumatoid Arthritis effects, and conducted a preliminary exploration for the application of nucleic acid drugs in the treatment of diseases outside of tumors. This research would provide new ideas for the treatment of RA.

Influence of calcium carbonate on ferrihydrite bio-transformation and associated arsenic mobilization/redistribution.

The sulfate-reducing bacteria (SRB)-induced ferrihydrite transformation is an important cause for arsenic (As) contamination in the aquifer near mining area. Calcium carbonate (CaCO) is widespread and has the potential of regulating As fate directly or indirectly. However, the influence of CaCO on ferrihydrite transformation and the associated As mobilization/redistribution in SRB-containing environments remains unclear.

Modelling PFAS Transport in Lake Ekoln: Implications for Drinking Water Safety in the Stockholm Region.

Per- and polyfluoroalkyl substances (PFAS) are found frequently in both groundwater and surface water sources across Sweden posing challenges to drinking water supply. Lake Ekoln is located south of Uppsala and is the basin of Lake Mälaren; Lake Mälaren is the third largest lake in Sweden and is the drinking water source for more than two million people. The aim of this study was to simulate the fate and transport of PFAS in Lake Ekoln during the period 2017 - 2020 using three-dimensional hydrodynamic modelling.

Bt toxins alter bacterial communities and their potential functions in earthworm intestines.

The accumulation and persistence of Bt toxins in soils from Bt plants and Bt biopesticides can result in ecological hazards. Earthworms are one of the most frequently used bioindicators for soil ecological monitoring, characterization, and risk assessment. However, the effects of Bt toxins on earthworm bacterial communities have conversely rarely been studied.

Natural polysaccharide hydrogel delivery system remodeling tumor microenvironment to promote postoperative tumor therapy.

In recent years, postoperative tumor therapy with a suitable approach has been an important issue. Remodeling the tumor microenvironment and accelerating tissue repair can accelerate patients' surgical site recovery, reduce patient pain as well as prevent postoperative tumor recurrence. The shape non-adaptability, cytotoxicity, and non-degradability of some hydrogels still hinder the application of hydrogel-based drug delivery systems in postoperative recovery.

Patulin-degrading enzymes sources, structures, and mechanisms: A review.

Patulin (PAT), a fungal secondary metabolite with multiple toxicities, is an unavoidable contaminant in fruit and vegetable processing, posing potential health risks to consumers and causing significant economic losses to the global food industry. Traditional control strategies, such as physical and chemical methods, face several challenges, including low efficiency, high costs, and unverified safety. In contrast, microbial degradation of patulin is considered a more efficient and environmentally friendly approach, which has become a popular research focus.

Deep eutectic solvent pretreatment of oil palm biomass: Promoted lignin pyrolysis and enzymatic digestibility of solid residues.

Herein, choline chloride/oxalic acid (ChCl/OA) and choline chloride/oxalic acid/ethylene glycol (ChCl/OA/EG) pretreatments of oil palm empty fruit bunches (EFB) and mesocarp fibers (MSF) were conducted to achieve protection of the lignin structure, while improving the enzymatic efficiency of the solid residues. Under the operating conditions of 90 °C and 6 h, ChCl/OA/EG demonstrated a higher lignin extraction selectivity and obtained solid residues with higher hemicellulose content compared to ChCl/OA. The digestibility of glucan and xylan in solid residues obtained using ChCl/OA/EG achieved 98.

Injectable dual-network hyaluronic acid nanocomposite hydrogel for prevention of postoperative breast cancer recurrence and wound healing.

High locoregional recurrence rates and potential wound infections remain a significant challenge for postoperative breast cancer patients. Herein, we developed a dual-network hyaluronic acid (HA) nanocomposite hydrogel composed of herring sperm DNA (hsDNA) bridged methacrylated HA (HAMA) and FeMg-LDH-ppsa nanohybrid chelated catechol-modified HA (HADA) for the prevention of breast cancer recurrent, anti-infection, and promoting wound healing. Dynamic reversible hsDNA cross-linking combined with metal-catechol chelating renders the hydrogel injectability, rapid self-healing ability, and enhanced mechanical properties.

Structural Basis of the Bifunctionality of Marinobacter salinexigens ZYF650 Glucosylglycerol Phosphorylase in Glucosylglycerol Catabolism.

2-O-α-Glucosylglycerol (GG) is a natural heteroside synthesized by many cyanobacteria and a few heterotrophic bacteria under salt stress conditions. Bacteria produce GG in response to stimuli and degrade it once the stimulus diminishes. Heterotrophic bacteria utilize GG phosphorylase (GGP), a member of the GH13_18 family, via a two-step process consisting of phosphorolysis and hydrolysis for GG catabolism.

The nucleic acid detection using CRISPR/Cas biosensing system with micro-nano modality for point-of-care applications.

Nucleic acid detection is considered the golden standard for diagnosing infectious diseases caused by various pathogens, including viruses, bacteria, and parasites. PCR and other amplification-based technologies are highly sensitive and specific, allowing for accurate detection and identification of low-level causative pathogens by targeting and amplifying their unique genetic segment (DNA or RNA). However, it is important to recognize that machinery-dependent diagnostic methods may only sometimes be available or practical in resource-limited settings, where direct implementation can be challenging.

Mandibular bone defect healing using polylactic acid-nano-hydroxyapatite-gelatin scaffold loaded with hesperidin and dental pulp stem cells in rat.

Addressing mandibular defects poses a significant challenge in maxillofacial surgery. Recent advancements have led to the development of various biomimetic composite scaffolds aimed at facilitating mandibular defect reconstruction. This study aimed to assess the regenerative potential of a novel composite scaffold consisting of polylactic acid (PLA), hydroxyapatite nanoparticles (n-HA), gelatin, hesperidin, and human dental pulp stem cells (DPSCs) in a rat model of mandibular bone defect.

Enhanced electro-catalysis for methanol oxidation reaction performance by edge defects of ordered mesoporous carbon.

Heteroatom-doped carbon materials are widely used to improve the electrocatalytic oxidation of methanol; however, the underlying mechanisms driving this enhancement remain poorly understood. A major challenge lies in developing non-doped carbon supports with tunable intrinsic defect types tailored for metal-based catalysts. In this study, we synthesize a series of ordered mesoporous carbon (OMC) supports with adjustable edge defect densities by varying roasting temperatures and employing a zinc (Zn) evaporation strategy to systematically investigate the impact of edge defects on methanol oxidation reaction (MOR) performance.

Adjustment of the GRACE Score and SHAP Analysis in STEMI Patients.

Background: The GRACE (Global Registry of Acute Coronary Events) risk score is a well-established tool for predicting major cardiovascular events in patients with acute coronary syndrome. However, its application in acute ST-segment elevation myocardial infarction (STEMI) requires refinement to enhance its predictive accuracy in clinical settings.

Methods: In this study, we conducted a retrospective analysis of the incidence of out-of-hospital all-cause death (ACD), calculated the correlation and significance of the GRACE score indicators with ACD, and reduced the scores corresponding to insignificant and low-correlation indicators to adjust the scores for survive patients.

Simplifying coronary artery disease risk stratification: development and validation of a questionnaire-based alternative comparable to clinical risk tools.

Background: Coronary artery disease (CAD) comprises one of the leading causes of morbidity and mortality both in the European population and globally. All established clinical risk stratification scores and models require blood lipids and physical measurements. The latest reports of the European Commission suggest that attracting health professionals to collect these data can be challenging, both from a logistic and cost perspective, which limits the usefulness of established models and makes them unsuitable for population-wide screening in resource-limited settings, i.

Adults living with dementia and chronic wounds, wound types, care challenges, and impact across dementia stages: A scoping review protocol.

Objective: The objective of this scoping review is to map the existing evidence on the epidemiology, care challenges, and impacts of various wound types among individuals living with dementia across different stages of the disease.

Introduction: Dementia is a growing global health concern, projected to rise significantly as the population ages. This condition not only affects cognitive function but also increases the risk of chronic wounds in part due to impairments in mobility, self-care, and communication.

Reduced graphene oxide prepared by cold plasma green treatment in liquid phase for fluorescence biosensing of tropomyosin in shrimp.

Graphene oxide (GO), renowned for its two-dimensional structure and exceptional fluorescence quenching capabilities, is a preferred choice for the construction of fluorescence biosensors. As the sensitivity demands for these sensors escalate, enhancing the fluorescence quenching performance of GO and reducing background fluorescence become paramount to optimize the sensor sensitivity. In this study, the use of cold plasma (CP) treatment with glucose solution as a reducing agent to refine GO into reduced graphene oxide (r-GO) with optimal fluorescence quenching abilities was explored.