Determination of knowledge, attitude and practice of voluntary counseling testing on HIV among youths from Tepi Town, Ethiopia.

Objective: Voluntary counseling and testing (VCT) is an integral component of HIV prevention and care strategies worldwide. VCT is considered as an effective strategy in risk reduction among sexually active youth. There is a high burden of HIV in Ethiopia despite a considerable scale up of comprehensive HIV interventions.

A Review of the Therapeutic Importance of Indole Scaffold in Drug Discovery.

Indole is known as a versatile heterocyclic building block for its multiple pharmacological activities and has a high probability of success in the race for drug candidates. Many natural products, alkaloids, and bioactive heterocycles contain indole as the active principle pharmacophore. These encourage the researchers to explore it as a lead in the drug development process.

A Mini-review on Recent Advances in Synthesis of Dihydropyrano [3, 2-c] chromenes Using Magnetic Nanocatalysts.

The development of an active, selective, and long-term selective catalyst for the synthesis of biologically active heterocycles is still challenging. However, magnetic nanocatalysts have divergent applications like high efficiency, selectivity, consumption, and reusability. The current review explores a detailed survey of the latest information on synthetic methods of Pyrano [3, 2-c] chromene derivatives using different magnetic nanocatalysts.

Unraveling the access to the regioselective synthesis of highly functionalized pyranopyrazoles using an ionic liquid catalyst.

An efficient and green strategy for the regioselective synthesis of highly functionalized pyranopyrazole via one-pot condensation of 3-methyl-1-phenyl-5-pyrazolone or EAA and hydrazine hydrate, substituted aromatic aldehydes with NMSM [(E)-N-Methyl-1-(methylthio)-2-nitro-ethenamine] in the existence of IL [(EMIM)Ac] as catalyst with solvent-free condition (SFC) is described. This domino protocol produces biologically substantial heterocycles through Knoevenagel condensation proceeded by Michael addition and O-cyclization with an eradication of methanethiol group, which create the one stereo-center and creation of "C-C, C-N, C-O, C=C, C=N, bonds." The final product is produced by exceptionally easy filtering after the reaction mass was triturated with ethanol.

GC/MS and LC/MS Phytochemical Analysis of Vigna unguiculata L. Walp Pod.

Vigna unguiculata (L. Walp) or Cowpea pod methanolic extracts phytochemical analysis, total phenolic content (TPC), and secondary metabolite profiling were determined using gas chromatography-mass spectrometry (GC/MS) and liquid chromatography-mass spectrometry (LC/MS) analysis. GC/MS analysis revealed twenty compounds in the extract, while LC/MS analysis identified twenty-four compounds.

Draft Genome Sequence Analysis of the Genotype II African Swine Fever Virus from India.

African swine fever virus (ASFV) entered the northeastern (NE) part of India early in 2020, causing huge economic loss to the piggery sector. Here, we are presenting a brief report on the draft genome sequence of an ASFV strain ABTCVSCK_ASF007 from Assam state of NE India belonging to genotype II.

Prevalence of Entamoeba histolytica among schoolchildren in Dilla town, Gedeo zone, Ethiopia.

Background: To measure the prevalence of Entamoeba histolytica (E. histolytica) infections and associated risk factors among schoolchildren in Dilla town, Gedeo zone Ethiopia.

Methods: A total of 501 schoolchildren were recruited by random sampling.

Zwitterion to normal formation of L-Alanine in water solvation as an ultrasonic impact from their Gibbs energy barrier: Experiment with different molarities and DFT simulation for few basis sets.

l-Alanine has Physiological significance, and their molecular interaction is subjected to the Gibbs energy barrier. The present study has reported the Gibb's energy barrier of l-Alanine (l-Ala) from 20.095 to 20.

Metabolomics Profiling of Pituitary Adenomas by Raman Spectroscopy, Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy, and Mass Spectrometry of Serum Samples.

To date, no studies are available in which pituitary adenomas (PAs) have been studied using techniques like confocal Raman spectroscopy, attenuated total reflection-Fourier transform infrared (FT-IR), and liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the same serum samples. To understand the metabolomics fingerprint, Raman spectra of 16 acromegaly, 19 Cushing's, and 33 nonfunctional PA (NFPA) and ATR-FTIR spectral acquisition of 16 acromegaly, 18 Cushing's, and 22 NFPA patient's serum samples were acquired. Next, Principal component-based linear discriminant analysis (PC-LDA) models were developed, Raman spectral analysis classified acromegaly with an accuracy of 79.

Biofilm inhibition in Candida albicans with biogenic hierarchical zinc-oxide nanoparticles.

The present study demonstrates lignin (L), fragments of lignin (FL), and oxidized fragmented lignin (OFL) as templates for the synthesis of zinc oxide nanoparticles (ZnO NPs) viz., lignin-ZnO (L-ZnO), hierarchical FL-ZnO, and OFL-ZnO NPs. The X-ray diffraction patterns confirmed the formation of phase pure ZnO NPs with a hexagonal wurtzite structure.

Assessment of antibacterial and anti-biofilm effects of zinc ferrite nanoparticles against Klebsiella pneumoniae.

In response to the emergence of drug resistance and limited therapeutic options, researchers are in action to look for more effective and sustainable antimicrobial practices. Over few years, novel nanoparticles are proving to be potent and promising for effectively dealing with ever- evolving microbial pathogens and diseases. In the present investigation, antibacterial and anti-biofilm efficiencies of zinc ferrite nanoparticles (ZnFeO NPs) are explored against opportunistic pathogens Klebsiella pneumoniae (K.

Recent Advances in Synthesis and Anticancer Potential of Triazole-Containing Scaffolds.

Cancer is the most lethal disease that may be found anywhere globally. Approximately 10% of individuals die due to cancer of various types, with 19.3 million new cancer cases and 10 million deaths reported in 2020.

Novel red colour emitting Ca Mg (SO ) :0.5Eu phosphor under ultraviolet, blue, and green excitation for plant growth LEDs.

In the recent few years, Eu - and Mn -activated phosphors are widely used as potential colour converters for indoor plant cultivation lighting application due to their marvellous luminescence characteristics as well as low cost. In this investigation, we synthesized novel red colour-emitting Ca Mg (SO ) :xmol% Eu (x = 0-1.0 mol%) phosphors via a solid-state reaction method in a reducing atmosphere.

Phytochemical analysis by GC-MS, LC-MS complementary approaches and antimicrobial activity investigation of (L.) Walp. leaves.

Consumption of legumes has long been linked to their nutritional and medicinal benefits. (L.) Walp.

First complete genome characterization of duck plague virus from India.

In this study, we report the complete genome sequencing of the Duck plague virus from India for the first time. The sequencing was done on the MinION nanopore sequencer from Oxford Nanopore Technologies. The closest relative is the European strain 2085v, with 99.

Sustainable Agriculture through Multidisciplinary Seed Nanopriming: Prospects of Opportunities and Challenges.

The global community decided in 2015 to improve people's lives by 2030 by setting 17 global goals for sustainable development. The second goal of this community was to end hunger. Plant seeds are an essential input in agriculture; however, during their developmental stages, seeds can be negatively affected by environmental stresses, which can adversely affect seed vigor, seedling establishment, and crop production.

Sawmill waste derived carbon dots as a fluorescent probe for synthetic dyes in soft drinks.

Herein, for the first time the carbon dots (CDs) were synthesized by reflux method from sawmill waste material. We also represent a novel strategy based on fluorescent CDs for determination of ponceau 4R and allura red dyes in soft drinks. Interestingly, both the dyes were sensitive and showed effective fluorescence quenching of the CDs owing to the interaction between them.

Microwave prompted solvent-free synthesis of new series of heterocyclic tagged 7-arylidene indanone hybrids and their computational, antifungal, antioxidant, and cytotoxicity study.

In this study, we report the expeditious synthesis of ten new antifungal and antioxidant agents containing heterocyclic linked 7-arylidene indanone moiety. The solvent-free microwave technique, ample substrate scope, superfast synthesis, and very simple operation are noteworthy features of this protocol. Antifungal activities of the newly synthesized compounds were evaluated against four fungal strains namely Rhizophus oryzae, Mucor mucido, Aspergillus niger, and Candida albicans.

Natural Feedstock in Catalysis: A Sustainable Route Towards Organic Transformations.

Catalysts are the jewel in the crown of the chemical industry, accelerating reaction kinetics and augmenting the efficiency of desired reaction paths. Natural feedstock is a renewable resource capable of providing valuable functional products; in addition, it confers an opportunity to create catalysts. As an alternative to stoichiometric reagents, and as a part of a sustainable approach, the implications of using natural feedstocks as a source of new catalysts has attracted considerable interest.

Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: In vitro screening, molecular docking and ADME predictions.

Novel non-camptothecin (non-CPT) class of conformationally constrained, hitherto unknown 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives have been designed, synthesized and evaluated for anti-cancer activity. In vitro anti-proliferation evaluation against human cancer cell lines (A549 and MCF-7) exhibited significant cytotoxicity. Among the derivatives (8-24), 8 (IC 0.

TiO-Doped NiCuZnFeO Nanoparticles for Enhanced Structural and Magnetic Properties.

TiO (0-10 wt %)-doped nanocrystalline NiCuZnFeO (Ni-Cu-Zn) ferrites were synthesized using the sol-gel route of synthesis. The cubic spinel structure of the ferrites having the 3 space group was revealed from the analysis of Rietveld refined X-ray diffraction (XRD) data. The secondary phase of TiO with a space group of 41/ was observed within the ferrites with doping, > 3 wt %.

Coconut-Water-Mediated Carbonaceous Electrode: A Promising Eco-Friendly Material for Bifunctional Water Splitting Application.

The organic and eco-friendly materials are extended to prevail over the worldwide energy crisis where bio-inspired carbonaceous electrode materials are being prepared from biogenic items and wastes. Here, coconut water is sprayed over three-dimensional (3D) nickel foam for obtaining a carbonaceous electrode material, i.e.

Effect of CD6 on serum lipid profile and indicators of liver function in high-fat diet fed Swiss albino mice.

In this study, we have investigated the effect of CD6 on weight gain, lipid profile, liver function biomarkers (ALT: alanine aminotransferase; and AST: aspartate aminotransferase) and liver histopathology in high-fat diet fed Swiss albino mice. Twenty-four healthy male Swiss albino mice with an average body weight of 25.94 ± 0.

Microwave-assisted combustion synthesis and luminescence properties of colour-tunable Eu /Tb co-doped BaLaB O.

In the present study, hexagonal structured borate phosphors BaLaB O were prepared using a combustion method with colour-tunable emission properties achieved by varying the doping concentration of Eu and Tb in the cluster. The as-prepared materials were analyzed for structural and morphological parameters through X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEM) studies. Tuning of colour was predicted through the photoluminescence and photoluminescence excitation spectra of the materials that showed good green and red emissions when doped with Tb and Eu , respectively, whereas the emission of the co-doped sample (Eu and Tb ) can be varied from the green region to red region by varying the excitation range from 207 to 254  nm.