Modeling Metformin and Dapagliflozin Pharmacokinetics in Chronic Kidney Disease.

Chronic kidney disease (CKD) is a complication of diabetes that affects circulating drug concentrations and elimination of drugs from the body. Multiple drugs may be prescribed for treatment of diabetes and co-morbidities, and CKD complicates the pharmacotherapy selection and dosing regimen. Characterizing variations in renal drug clearance using models requires large clinical datasets that are costly and time-consuming to collect.

Microaggressions in Nursing.

How to address these behaviors to promote health equity and inclusion.

What Should Students and Trainees Learn About Patient-Centered Documentation?

What clinicians document about patients can have important consequences for those patients. Paternalistic language in patients' health records is of specific ethical concern because it emphasizes clinicians' power and patients' vulnerabilities and can be demeaning and traumatizing. This article considers the importance of person-centered, trauma-informed language in clinical documentation and suggests strategies for teaching students and trainees documentation practices that express clinical neutrality and respect.

Creating a Pathway to Health-Care Professions for Historically Marginalized Students.

Developing a diverse talent pool starting at the high-school level, while students are making future education and career decisions, should be a national priority, given the need to build a diverse health-care workforce. This article describes a 6-week immersive simulation-based summer program to introduce 20 junior high-school students (13-15 years old) to the range of health professions. Because precollege students typically receive limited exposure to clinical settings, high-fidelity simulation is an excellent surrogate for providing realistic experiences in health care.

How Does Racial Segregation Taint Medical Pedagogy?

Persistence of racial segregation makes equitable health care impossible for African Americans, as does the supra-geographic segregation perpetuated by enduring racial medical mythologies that remain unchallenged in health professions education. This article canvasses how these mythologies exacerbate myopia in health professions practice and education, maintain barriers, and perpetuate racial health inequity.

Asylums and Harm Embodiment.

This article examines iatrogenic harms incurred by closed-ward psychiatric hospitals. In particular, this article considers roles of narrative in one patient's experience of life-encompassing iatrogenic harm from being institutionalized from infancy to age 60 and also emphasizes Italy's comparative success, relative to the United States, in recovering from decades of deinstitutionalization to establish community-based mental health care.

Abolitionist Reimaginings of Health.

In 2020, the authors of this article published "Abolition Medicine" as one contribution to international abolitionist conversations responding to widespread anti-Black police violence and inequity laid bare by the COVID-19 pandemic. Over the past year, there has been a surge of efforts to abolish deeply embedded patterns of race-based oppression in policing and incarceration in the United States. In this essay, the authors continue to explore how health care can join these conversations and move toward a praxis of health justice.

GeDi: applying suffix arrays to increase the repertoire of detectable SNVs in tumour genomes.

Background: Current popular variant calling pipelines rely on the mapping coordinates of each input read to a reference genome in order to detect variants. Since reads deriving from variant loci that diverge in sequence substantially from the reference are often assigned incorrect mapping coordinates, variant calling pipelines that rely on mapping coordinates can exhibit reduced sensitivity.

Results: In this work we present GeDi, a suffix array-based somatic single nucleotide variant (SNV) calling algorithm that does not rely on read mapping coordinates to detect SNVs and is therefore capable of reference-free and mapping-free SNV detection.

The effects of land use change and precipitation change on direct runoff in Wei River watershed, China.

The principles and degrees to which land use change and climate change affect direct runoff generation are distinctive. In this paper, based on the MODIS data of land use in 1992 and 2003, the impacts of land use and climate change are explored using the Soil Conservation Service Curve Number (SCS-CN) method under two defined scenarios. In the first scenario, the precipitation is assumed to be constant, and thus the consequence of land use change could be evaluated.

A dual-chamber system for screening cytotoxic effects of hybridoma-produced antibodies.

There are many methods for evaluating the cytotoxic effect of monoclonal antibodies (MAbs) against cancer cells. Most of these methods require either purified MAbs or biological solutions (e.g.

Feasibility and efficacy of pairing fecal immunochemical testing with mammography for increasing colorectal cancer screening among uninsured Latinas in northern Manhattan.

Objectives: We evaluated the feasibility and efficacy of a program to promote colorectal cancer screening (CRC) among uninsured Latinas receiving mammography through a cancer screening clinic in northern Manhattan.

Methods: Between August 2009 and March 2010, unscreened, average CRC risk, uninsured Latinas, aged 50-64 years, undergoing mammography received a screening recommendation, education, and fecal immunochemical test (FIT). Socio-demographic information and level of acculturation was collected.

Points of contact: using first-person narratives to help foster empathy in psychiatric residents.

Objective: The authors aimed to determine if writing narratives in psychiatric training can foster empathy for severely and persistently mentally ill patients.

Methods: One resident wrote first-person narrative pieces about three different patients at a community mental health clinic. She reviewed these pieces with a writing supervisor weekly.

Community--academia partnerships to promote nutrition in the lower Mississippi delta: community members' perceptions of effectiveness, barriers, and factors related to success.

This study examined the perceptions of community members' engaged in community-academia partnerships involved in developing nutrition interventions in three communities in the Lower Mississippi Delta. Perceptions on effectiveness of the partnerships were investigated. Six focus group interviews were conducted, with 33 participants that included 27 females and 6 males.

The impact of Medicare Part D on prescription drug use by the elderly.

This study investigates the effect of Medicare Part D on the elderly's prescription drug use and out-of-pocket costs using a difference-in-differences research design. We estimate that Medicare Part D reduced user cost among the elderly by 18.4 percent, increased their use of prescription drugs by about 12.

Obvious and not-so-obvious strategies to disseminate research.

The findings of health disparities research will have to be disseminated to a broad public in order to influence health outcomes. Some strategies for dissemination are obvious, and these generally work for ideas that are within the mainstream of current paradigms. However, ideas that challenge existing theories and assumptions may require different, and not-so-obvious, strategies.

Are Religious Women More Likely to Have Breast Cancer Screening?

The study objective was to investigate whether women who frequently attend religious services are more likely to have breast cancer screening-mammography and clinical breast examinations-than other women. Multivariate logistic regression models show that white women who attended religious services frequently had more than twice the odds of breast cancer screening than white women who attended less frequently (Odds Ratio (OR) = 2.61; 95% Confidence Interval (CI) = 1.