Long-Term Survival Following Coronary Artery Bypass Graft Surgery.

Background: Management guidelines for stable three-vessel coronary artery disease have become a subject of debate. We aim to provide a benchmark for the survival of patients with normal ejection fraction, stable three-vessel disease, and elective coronary artery bypass graft (CABG) surgery.

Methods: Data from consecutive patients with normal ejection fraction undergoing elective primary isolated CABG for triple-vessel disease in a diverse 11-center surgical network between 2008 and 2020 were analyzed.

System-failing creativity in health care.

Introduction: Health care professionals often generate novel solutions to solve problems during day-to-day patient care. However, less is known about generating novel and useful (i.e.

Combining Individual-Based Radio-Tracking With Whole-Genome Sequencing Data Reveals Candidate for Genetic Basis of Partial Migration in a Songbird.

Partial migration is a phenomenon where migratory and resident individuals of the same species co-exist within a population, and has been linked to both intrinsic (e.g., genetic) as well as environmental factors.

Cardiovascular patches applied in congenital cardiac surgery: Current materials and prospects.

Congenital Heart Defects (CHDs) are the most common congenital anomalies, affecting between 4 and 75 per 1000 live births. Cardiovascular patches (CVPs) are frequently used as part of the surgical armamentarium to reconstruct cardiovascular structures to correct CHDs in pediatric patients. This review aims to evaluate the history of cardiovascular patches, currently available options, clinical applications, and important features of these patches.

Genetic Variation in Male Mate Choice for Large Females in .

Males in many species show courtship and mating preferences for certain females over others when given the choice. One of the most common targets of male mate choice in insects is female body size, with males preferring to court and mate with larger, higher-fecundity females and investing more resources in matings with those females. Although this preference is well-documented at the species level, less is known about how this preference varies within species and whether there is standing genetic variation for male mate choice within populations.

Steric stabilization of colloidal UiO-66 nanocrystals with oleylammonium octadecylphosphonate.

We report the synthesis and characterization of octahedral UiO-66 nanocrystals ( = 17-25 nm) terminated with amine, oleate, and octadecylphosphonate ligands. Acetate capped UiO-66 nanocrystals were dispersed in toluene using oleic acid and oleylamine. Ligand exchange with octadecylphosphonic acid produces ammonium octadecylphosphonate terminated nanocrystals with coverages of 2.

Tuning Earth System Models Without Integrating to Statistical Equilibrium.

This paper proposes algorithms for estimating parameters in Earth System Models (ESMs), specifically focusing on simulations that have not yet achieved statistical equilibrium and display climate drift. The basic idea is to treat ESM time series as outputs of an autoregressive process, with parameters that depend on those of the ESM. The maximum likelihood estimate of the parameters and the associated uncertainties are derived.

Loneliness, emotional support and the mental health of young adults and their parents in New York, US during the COVID-19 pandemic: a cohort study.

Background: The coronavirus disease (COVID-19) pandemic led to social isolation and widespread lockdown, resulting in loneliness and lack of emotional support, which have been associated with adverse mental health outcomes. This study aims to explore the relationship of loneliness and emotional support with depression and substance use among young adults and their parents during the COVID-19 pandemic.

Methods: A cohort of 1227 participants was recruited from three ongoing cohort studies in the metropolitan area of New York City, USA.

Association of plasma neurofilament light chain with microstructural white matter changes in Down syndrome.

Introduction: Both micro- and macrostructural white matter (WM) abnormalities, particularly those related to axonal degeneration, are associated with cognitive decline in adults with Down syndrome (DS) prior to a diagnosis of Alzheimer disease. Neurofilament light chain (NfL) is a support protein within myelinated axons released into blood following axonal damage. In this study we investigated cross-sectional relationships between WM microstructural changes as measured by diffusion tensor imaging (DTI) and plasma NfL concentration in adults with DS without dementia.

An Improved Bio-Physical Parameterization for Ocean Radiant Heating in Conditions of Near-Surface Stratification.

Solar heating of the upper ocean is a primary energy input to the ocean-atmosphere system, and the vertical heating profile is modified by the concentration of phytoplankton in the water, with consequences for sea surface temperature and upper ocean dynamics. Despite the development of increasingly complex modeling approaches for radiative transfer in the atmosphere and upper ocean, the simple parameterizations of radiant heating used in most ocean models can be significantly improved in cases of near-surface stratification. There remains a need for a parameterization that is accurate in the upper meters and contains an explicitly spectral dependence on the concentration of biogenic material, while maintaining the computational simplicity of the parameterizations currently in use.

Viscoelasticity of globular protein-based biomolecular condensates.

The phase separation of biomolecules into biomolecular condensates has emerged as a ubiquitous cellular process. Understanding how intrinsically disordered protein sequence controls condensate formation and material properties has provided fundamental biological insights and led to the development of functional synthetic condensates. While these studies provide a valuable framework to understand subcellular organization phase separation they have largely ignored the presence of folded domains and their impact on condensate properties.

Solar Panels as Novel Nest Sites for the European Paper Wasp .

Solar energy facilities are rapidly expanding in their land-use footprint worldwide, with significant implications for biodiversity. Although the impacts of conventional solar development are often negative for biodiversity, it is possible for some species to take advantage of the novel anthropogenic structures and microhabitats provided by solar facilities. We describe the frequent nesting of non-native European paper wasps () at two solar facilities in the Central Valley of California (USA), conducting nest censuses to further investigate population density and nest siting behaviour.

A circuit model for transsaccadic space updating and mislocalization.

We perceive a stable, continuous world despite drastic changes of retinal images across saccades. However, while objects in daily life appear stable across saccades, stimuli around saccades can be grossly mislocalized. We address this puzzle with our recently proposed circuit model for perisaccadic receptive-field (RF) remapping in LIP and FEF.

Durable mixed chimerism may permit subsequent immunosuppression-free intestinal transplantation-A proof-of-principle study.

Intestinal transplantation (ITx) is the definitive treatment for intestinal failure but has the highest rejection rate among solid organ transplants, requiring high doses of immunosuppressive medication, which is associated with high rates of infection, graft-versus-host disease, and malignancy. Transplant tolerance would overcome the need for long-term immunosuppression (ISP). Using nonmyeloablative conditioning, our laboratory has developed a novel swine model of hematopoietic stem cell transplantation (HSCT) that produces durable mixed chimerism (MC) and immune tolerance without toxicity.

Evaluation of bleeding risk in patients who received pirtobrutinib in the presence or absence of antithrombotic therapy.

Clinical bleeding events are reported here from 773 patients with B-cell malignancies receiving pirtobrutinib monotherapy from the phase 1/2 BRUIN study (ClinicalTrials.gov identifier: NCT03740529), either in the presence or absence of antithrombotic therapy (antithrombotic exposed [AT-E],  = 216; antithrombotic nonexposed [AT-NE],  = 557). Among the AT-E cohort, 51.