125 results match your criteria: "Columbia University Irving Medical Center-NewYork Presbyterian Hospital[Affiliation]"

Background: Cardiac allograft vasculopathy (CAV) results in impaired blood flow in both epicardial vessels and the microvasculature and is a leading cause of poor outcomes in heart transplant (HT) recipients. Most patients have mild (International Society for Heart and Lung Transplantation [ISHLT] CAV 1) disease. This study examined outcomes among those with ISHLT CAV 1 and investigated the value of physiologic assessment via cardiac positron emission tomography/computed tomography (PET/CT) for added risk stratification.

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Article Synopsis
  • The study assesses the return to performance of MLB pitchers after undergoing ulnar collateral ligament (UCL) surgery using advanced analytics and pitch-tracking metrics.
  • At 1, 2, and 3 years post-surgery, the data showed that only 1.6% of pitchers returned to play within the first year, but the rates increased significantly to 71.9% at 2 years and 82.0% at 3 years.
  • The research highlights the importance of modern metrics, examining factors like expected fielding independent pitching and velocity, to evaluate pitchers' recovery and performance levels after surgery.
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Background: Understanding the conduction axis location aids in avoiding iatrogenic damage and guiding targeted heart rhythm therapy.

Objective: Cardiac structures visible with clinical imaging have been demonstrated to correlate with variability in the conduction system course. We aimed to standardize and assess the reproducibility of predicting the location of the atrioventricular conduction axis by cardiac computed tomography.

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The waiting is the hardest part.

J Heart Lung Transplant

December 2024

Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center/NewYork-Presbyterian Hospital, New York, New York.

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Background: Renal-artery stenosis can be associated with difficult to control hypertension, although renal-artery stenting has not been shown to improve clinical outcomes. Alternative antihypertensive medications could potentially result in quality of life benefits with renal-artery stenting.

Methods: We performed a pre-specified quality of life sub-study of the CORAL trial-multicenter, randomized, open-label trial of renal-artery stenting versus medical therapy in patients with atherosclerotic renal-artery stenosis.

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Effects of Catheter-Based Renal Denervation in Hypertension: A Systematic Review and Meta-Analysis.

Circulation

November 2024

Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Universität des Saarlandes, Homburg, Germany (D.V., L.L., M.B., F.M.).

Article Synopsis
  • A meta-analysis of randomized, sham-controlled trials was conducted to evaluate the effectiveness and safety of catheter-based renal denervation (RDN) in treating hypertension, involving 10 trials with a total of 2,478 patients.
  • The study found that RDN significantly lowered both 24-hour and office systolic and diastolic blood pressure compared to sham procedures, without a notable difference in complications or changes in renal function.
  • Overall, RDN appears to be a safe and effective method for reducing blood pressure in patients with hypertension, although significant variability was noted among the studies analyzed.
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Objective: To evaluate the outcomes of transcatheter edge-to-edge repair (TEER) with MitraClip™ (Abbott Vascular) in symptomatic high surgical risk Indian patients with significant mitral regurgitation (MR).

Methods: Patients with moderately severe or severe primary or secondary MR and deemed high surgical risk were treated with MitraClip™. The data were collected retrospectively from medical records.

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  • The field of interventional cardiology (IC) has seen significant advancements and improved training programs over the last 40 years, including accredited fellowship programs and subspecialty certification.
  • Despite these improvements, the application process for IC fellowships has been chaotic and inconsistent, causing stress and pressure on applicants due to competitive recruitment practices.
  • A task force from the Society for Cardiovascular Angiography & Interventions has initiated a grassroots movement to create a national Match system for IC fellowships, aiming to establish fairness and equity in the application process.
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  • The study investigates the use of off-label peripheral drug-coated balloons (P-DCB) for treating coronary in-stent restenosis (ISR) in patients, as dedicated drug-coated balloons are not available in the U.S.
  • Data from 31 patients treated at a high-volume center showed that a significant percentage had recurrent ISR and high-grade symptoms, with most lesions found in native coronary arteries.
  • Follow-up indicated that while no post-procedural heart attacks occurred, there was a notable recurrence rate of ISR, with only 44.7% of patients free from further issues at the time of follow-up.
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  • Congestion is a key symptom of acute decompensated heart failure (ADHF) and often persists despite initial treatment, leading to poorer patient outcomes.* -
  • There is currently no standard definition for what constitutes successful decongestion, which complicates assessment and treatment planning.* -
  • The review suggests a new 4-class grading system for congestion and decongestion endpoints to improve consistency in ADHF research and patient care.*
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  • * Persistent congestion during increased diuretic treatment is an indicator of poor prognosis, leading to the development of new device-based therapies aimed at improving outcomes.
  • * The review identifies patient risk factors for severe congestion related to their past medical history, the extent of their congestion, how well they respond to diuretics, and their kidney function, while also outlining criteria for including high-risk patients in future studies.
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The Current Landscape of Transcatheter Tricuspid Valve Intervention.

J Soc Cardiovasc Angiogr Interv

December 2023

Section of Cardiovascular Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut.

Tricuspid regurgitation (TR) is common, and its prevalence increases with age. It was previously estimated that there are 1.6 million patients in the United States with moderate or worse TR, and more contemporary data suggest the age-adjusted prevalence of TR is 0.

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Article Synopsis
  • * A total of 205 patients participated, with a 1-year target-vessel failure (TVF) rate of 7.4%, significantly below the performance goal set at 24.5%, and a 3-year TVF rate of 12.1%.
  • * The findings indicate that using a provisional stenting approach for bifurcation lesions with the Resolute Onyx ZES led to positive clinical outcomes, suggesting it
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Article Synopsis
  • The purpose of the review is to summarize the current applications and evidence of cardiac CT technologies in preventing coronary artery disease (CAD).* -
  • Cardiac CT angiography (CTA) has become the primary non-invasive method for assessing symptomatic CAD, alongside other technologies like coronary calcium scoring and plaque analysis, though their effectiveness in enhancing risk prediction needs further exploration.* -
  • The review discusses barriers to using these technologies in primary prevention, the need for more research, and potential clinical approaches to incorporate cardiac CT in preventing CAD.*
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  • Many COVID-19 survivors from the early pandemic showed signs of cardiac injury, prompting investigations into long-term heart effects using cardiac imaging techniques like CMR and TTE.
  • A study involving 40 COVID-19 survivors and 12 matched controls conducted TTE and CMR at an average of 308 days post-infection, revealing no significant differences in heart structure, function, or tissue abnormalities between the groups.
  • The findings suggest that there is no lasting damage or inflammation to the heart in these survivors, despite previous reports of cardiac issues during acute COVID-19.
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  • Despite advancements in treatment, ST-elevation myocardial infarction (STEMI) still results in high mortality rates, leading to a greater focus on comfort-oriented care for those with poor prognoses.
  • In a study of 536 STEMI patients, 11.4% died during hospitalization, with a significant number transitioning to comfort-focused care, especially those on mechanical circulatory support.
  • Palliative care consultations were infrequent, occurring in only about 10% of cases, typically late in hospitalization, suggesting a need for earlier integration of comfort care strategies.
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  • * Many patients with serious symptoms of TR are included in clinical trials for new transcatheter devices, indicating they may be at an advanced stage of HFpEF.
  • * The review explores how treating HFpEF could influence TR's underlying issues and how changes after transcatheter TR treatment might improve symptoms and outcomes for HFpEF patients.
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The Society of Thoracic Surgeons Clinical Practice Guidelines on the Management of Neonates and Infants With Coarctation.

Ann Thorac Surg

September 2024

Congenital Heart Center, Division of Cardiovascular Surgery, Department of Surgery, University of Florida, Gainesville, Florida; Congenital Heart Center, Division of Cardiovascular Surgery, Department of Pediatrics, University of Florida, Gainesville, Florida. Electronic address:

Article Synopsis
  • Coarctation of the aorta is common in neonates and infants, but management guidelines for this condition are lacking, prompting a review by experts in congenital heart conditions.
  • A panel used the PICO framework to develop practice guidelines, concluding that surgery is typically indicated for isolated coarctation unless there are specific surgery risks, while medical management may be considered for at-risk patients.
  • The choice between thoracotomy and sternotomy for surgical intervention largely depends on the presence of arch hypoplasia, and further research is needed to improve management strategies for these patients.
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Background: Significant psychological impact and prevalence of posttraumatic stress disorder (PTSD) have been well documented in patients sustaining anterior cruciate ligament injury.

Purpose: To examine PTSD symptomatology in baseball players after sustaining elbow ulnar collateral ligament (UCL) injury.

Study Design: Cross-sectional study; Level of evidence, 3.

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  • Sarcopenia, or muscle loss, is often overlooked in patients with advanced heart failure, especially those undergoing heart transplants, but it significantly impacts postoperative outcomes.
  • This study found that patients with preoperative sarcopenia had fewer days alive and out of the hospital in the year following heart transplant, with a median difference of 17 days compared to those without sarcopenia.
  • The research highlights that diagnosing sarcopenia using pectoralis muscle-area index from CT scans could provide valuable insights for transplant evaluations and predict poorer outcomes.
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