Correlation Between Gender of Department Chairs and Paid Parental Leave Benefits in Academic Dermatology Residency Programs.

Background: Although the number of women entering dermatology residency programs is increasing, they still encounter numerous challenges and disparities, including limited career opportunities and difficulties in balancing family planning with their professional lives. Parental leave policies have been recognized for their positive impact on maternal, fetal, and familial well-being, career satisfaction, and gender equality. However, negative perceptions and a lack of awareness surrounding these policies may discourage female residents from taking parental leave during training.

Optical coherence tomography-enabled classification of the human venoatrial junction.

Significance: Radiofrequency ablation to treat atrial fibrillation (AF) involves isolating the pulmonary vein from the left atria to prevent AF from occurring. However, creating ablation lesions within the pulmonary veins can cause adverse complications.

Aim: We propose automated classification algorithms to classify optical coherence tomography (OCT) volumes of human venoatrial junctions.

Predicting the location of coordinated metal ion-ligand binding sites using geometry-aware graph neural networks.

More than 50 % of proteins bind to metal ions. Interactions between metal ions and proteins, especially coordinated interactions, are essential for biological functions, such as maintaining protein structure and signal transport. Physiological metal-ion binding prediction is pivotal for both elucidating the biological functions of proteins and for the design of new drugs.

Corrigendum: Enhancing enzyme-mediated cellulose hydrolysis by incorporating acid groups onto the lignin during biomass pretreatment.

[This corrects the article DOI: 10.3389/fbioe.2020.

Characterizing executive functioning and associated behaviors in individuals with dual-specificity tyrosine phosphorylation-regulated kinase 1A () syndrome.

Introduction: , a protein kinase located on human chromosome 21, plays a role in postembryonic neuronal development and degeneration. Alterations to have been consistently associated with cognitive functioning and neurodevelopmental disorders (e.g.

Do you have depression? A summative content analysis of mental health-related content on TikTok.

Background: TikTok is a global social media platform with over 1 billion active users. Presently, there are few data on how TikTok users navigate the platform for mental health purposes and the content they view.

Objective: This study aims to understand the patterns of mental health-related content on TikTok and assesses the accuracy and quality of the advice and information provided.

Initial clinical experience with [Lu]Lu-PNT2002 radioligand therapy in metastatic castration-resistant prostate cancer: dosimetry, safety, and efficacy from the lead-in cohort of the SPLASH trial.

Introduction: SPLASH (NCT04647526) is a multicenter phase III trial evaluating the efficacy and safety of [Lu]Lu-PNT2002 radioligand therapy in metastatic castration-resistant prostate cancer (mCRPC). This study leveraged a lead-in phase to assess tissue dosimetry and evaluate preliminary safety and efficacy, prior to expansion into a randomized phase. Here we report those results.

Students perspectives on the development and deployment of an AI-enabled service robot in long-term care.

The need for Artificial Intelligence (AI) in gerontology education is underscored by the potential benefits it offers in addressing loneliness and supporting social connection among older adults in long-term care (LTC) homes. While the workforce in LTC is often overburdened, AI-enabled service robots present possible solutions to enhance residents' quality of life. However, the incorporation of AI and service robots in current gerontology curricula is lacking, and the views of students on this subject remain largely unexamined.

Alcohol septal ablation in drug-refractory hypertrophic obstructive cardiomyopathy patient with multiple comorbidities.

Unlabelled: Septal reduction therapy is an effective treatment for hypertrophic obstructive cardiomyopathy (HOCM). Alcohol septal ablation (ASA) is indicated for HOCM patients who are ineligible for surgical myectomy, but several tips exist for the management of high-risk patients with ASA. Here, we present a case of successful ASA in a HOCM patient with multiple comorbidities, including severe obesity, drug-refractory bronchial asthma, poorly controlled diabetes, and steroid-induced immunosuppression.

Relationship between muscle power, muscle volume and limb length in healthy male and female adolescents.

Objective: Muscle power is essential for the activities of daily living. Muscle power production depends on numerous factors such as muscle size and length, muscle architecture and fiber type and varies with age during growth. The association between muscle power output during a jump and lower limb muscle volume and length in adolescents is largely unknown.

Perspective on strategies for matching across age and sex in physiology research: "recreationally active" is not good enough.

Cardiorespiratory fitness (CRF) and muscular fitness are powerful confounders in age and sex-related comparisons. This paper provides a perspective on the benefits and limitations of matching participants by physical activity behaviour, objectively measured fitness and normative fitness percentiles. Data presented herein are a subset of a larger study, and highlight that matching by physical activity, does not necessarily match on other metrics like physical fitness, especially when age-related comparisons are being made.

Distribution and determinants of the utilization of senior residential care homes in Saudi Arabia: a cross-sectional study.

Background: With the accelerated increase in the population of seniors aged 60 years or older in Saudi Arabia, understanding the utilization of senior residential care homes is crucial for improving service delivery and policy planning to meet the care transformation objectives of Vision 2030.

Objective: To assess the distribution and determinants of senior residential care home utilization across Saudi Arabia's 13 administrative regions, focusing on predictors of functional dependency among different socio-demographic groups.

Methods: This study analyzed data from 283 Saudi individuals aged ≥65 admitted to social residential care homes in 2021.

Reflecting on partnerships established and sustained over four cycles of a federally funded cancer prevention and control research program: lessons learned for community-academic networks.

Introduction: The Centers for Disease Control and Prevention (CDC) funded Cancer Prevention and Control Research Network (CPCRN) is a national network which aims to accelerate the adoption and implementation of evidence-based cancer prevention and control strategies and interventions in communities, enhance large-scale efforts to reach underserved populations and reduce their cancer-related health disparities, and develop the capacity of the dissemination and implementation work force specifically in cancer prevention and control.

Methods: Our site has been a part of the CPCRN since its inception in 2002 with the exception of the 2004-2009 funding cycle. As community-based participatory research is a core value of our center, we examined the development and continued engagement of our community partners using a qualitative, inductive approach to identify emergent themes from focus group sessions with current and past investigators.

Maternal, delivery and neonatal outcomes in women with cervical cancer. A study of a population database.

Importance: Cervical cancer is the fourth most common cancer among women globally and a significant cause of cancer-related deaths. Understanding the impact of cervical cancer diagnosed during pregnancy on maternal, delivery, and neonatal outcomes is crucial for improving clinical management and outcomes for affected women and their children.

Objective: To determine the effects of cervical cancer diagnosed during pregnancy on maternal, delivery, and neonatal outcomes using a population based, American database.

Constructing a metadata knowledge graph as an atlas for demystifying AI pipeline optimization.

The emergence of advanced artificial intelligence (AI) models has driven the development of frameworks and approaches that focus on automating model training and hyperparameter tuning of end-to-end AI pipelines. However, other crucial stages of these pipelines such as dataset selection, feature engineering, and model optimization for deployment have received less attention. Improving efficiency of end-to-end AI pipelines requires metadata of past executions of AI pipelines and all their stages.

Association of neighborhood-level socioeconomic disadvantage and Life's Essential 8 in early pregnancy.

We examined whether neighborhood-level socioeconomic disadvantage per the Area Deprivation Index (ADI) was associated with maternal cardiovascular health (CVH) in early pregnancy per the American Heart Association Life's Essential 8 (LE8). This is a cross-sectional analysis from the prospective Nulliparous Pregnancy Outcomes Study-Monitoring Mothers-to-Be Heart Health Study (nuMoM2b-HHS) cohort. The exposure was the ADI in tertiles (T) from least (T1) to most (T3) socioeconomic disadvantage.

Miniaturized Wearable Biosensors for Continuous Health Monitoring Fabricated Using the Femtosecond Laser-Induced Graphene Surface and Encapsulated Traces and Electrodes.

Wearable sensors are increasingly being used as biosensors for health monitoring. Current wearable devices are large, heavy, invasive, skin irritants, or not continuous. Miniaturization was chosen to address these issues, using a femtosecond laser-conversion technique to fabricate miniaturized laser-induced graphene (LIG) sensor arrays on and encapsulated within a polyimide substrate.

Estimated Factor Scores Are Not True Factor Scores.

In this tutorial, we clarify the distinction between estimated factor scores, which are weighted composites of observed variables, and true factor scores, which are unobservable values of the underlying latent variable. Using an analogy with linear regression, we show how predicted values in linear regression share the properties of the most common type of factor score estimates, regression factor scores, computed from single-indicator and multiple indicator latent variable models. Using simulated data from 1- and 2-factor models, we also show how the amount of measurement error affects the reliability of regression factor scores, and compare the performance of regression factor scores with that of unweighted sum scores.

Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease.

Vitronectin (VTN) is an important extracellular matrix protein in tissue remodeling, but its role in COPD is unknown. We show that VTN regulates tissue remodeling through urokinase plasminogen activator (uPA) signaling pathway in COPD. In human COPD airways and bronchoepithelial cells and the airways of mice with cigarette smoke (CS)-induced experimental COPD, VTN protein was not changed, but downstream uPA signaling was altered (increased plasminogen activator inhibitor-1, uPAR) that induced collagen and airway remodeling.

Investigating How All-Trans Retinoic Acid Polycaprolactone (atRA-PCL) Microparticles Alter the Material Properties of 3D Printed Fibrin Constructs.

The 3D printing of human tissue constructs requires carefully designed bioinks to support the growth and function of cells. Here it is shown that an additional parameter is how drug-releasing microparticles affect the material properties of the scaffold. A microfluidic platform is used to create all-trans retinoic acid (atRA) polycaprolactone (PCL) microparticles with a high encapsulation efficiency (85.

Adolescents Constructing Their Imagined Futures Through Dialogues With and/or About Nonfamilial Adults.

Introduction: Adolescents actively explore future imaginings as they prepare for major educational, work, and personal transitions. Although family members may support exploration of imagined futures, adults outside adolescents' kin network provide access to resources not supplied within the family. The purpose of this study was to understand how adolescents actively draw on social resources of nonfamilial adults relative to their imagined futures.

Do individuals with inflammatory arthritis receive minimally adequate treatment for incident depression and anxiety: A population-based study.

Objectives: Describe patterns of pharmacotherapy and psychological treatment and evaluate receipt of minimally adequate treatment for incident depression and anxiety in individuals with inflammatory arthritis (IA).

Methods: We used population-based linked administrative health databases from British Columbia, Canada to evaluate pharmacotherapy and psychological treatments for incident depression and/or anxiety among individuals with IA and without IA ('IA-free controls'). We defined minimally adequate pharmacotherapy as antidepressant prescriptions filled with ≥ 84 days' supply and adequate psychological treatment as ≥ 4 counselling/psychotherapy services.