Information on epilepsy genetics available online for people with epilepsy and their families.

Objective: To evaluate and compare the types of information available online about epilepsy genetics to people with epilepsy and their family members on websites and social media platforms.

Methods: To identify websites, we used the search terms "epilepsy," "genetic epilepsy," and "epilepsy genetics" in Google, using Incognito mode. We selected the first ten English, non-sponsored websites for analysis.

Post Kidney Transplant Hospitalizations and Long-term Outcomes: A Prospective Multi-Center Study.

Background: AKI is associated with an increased risk of CKD and ESKD. However, only limited studies have investigated the impact of AKI episodes on kidney transplant outcomes. This study evaluated the impact of rehospitalization associated with non-immunological AKI on long-term outcomes.

Preclinical Alzheimer's disease shows alterations in circulating neuronal-derived extracellular vesicle microRNAs in a multiethnic cohort.

Introduction: Alzheimer's disease (AD) is the leading cause of dementia, affecting around 50 million individuals worldwide. Brain-derived extracellular vesicles (EVs) can cross the blood-brain barrier carrying neuron-specific molecules, such as microRNAs (miRNAs), which have potential as biomarkers of neurodegeneration.

Methods: We explored the association between neuronal-derived EV miRNAs from serum and AD clinical status by performing a transcriptome-wide association study involving 46 participants with clinical AD, 14 participants with preclinical AD, and 60 neurologically healthy controls.

Spline Baseline Model Flexibility Independently Affects the Accuracy and Precision of In Vivo Proton Magnetic Resonance Spectral Fitting in a Metabolite-Specific Manner Not Visually Predicted by Fit Residuals.

In vivo proton magnetic resonance spectroscopy (H-MRS) data often exhibit baselines or low-amplitude signal variations resulting from residual water, imperfectly suppressed lipids, low-amplitude metabolites not considered for fitting, and other features not represented in a basis set. While multitudinous approaches exist to model these baselines in H-MR spectral analysis, many continue to lack systematic validation against varied and realistic ground-truth standards. Here, we compare the accuracy (error mean) and precision (error standard deviation) of metabolite scaling estimates by linear combination modeling (LCM) spectral fitting accounting for spectral baselines via smoothed cubic splines at 50 different combinations of fixed knot interval and smoothing weight, either with or without additionally simulated Gaussian basis signals to separately model spectral macromolecules.

Autoimmune Thyroid Diseases and Microscopic Colitis: A Nationwide Matched Case-Control Study in Sweden.

Background: Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is an inflammatory condition of the colon, characterized by watery diarrhoea. Previous studies suggest an association between autoimmune thyroid diseases (AITDs) (Hashimoto's thyroiditis and Graves' disease) and MC; however, large-scale histology studies are lacking.

Methods: We conducted a nationwide, matched case-control study.

micronuclAI enables automated quantification of micronuclei for assessment of chromosomal instability.

Chromosomal instability (CIN) is a hallmark of cancer that drives metastasis, immune evasion and treatment resistance. CIN may result from chromosome mis-segregation errors and excessive chromatin is frequently packaged in micronuclei (MN), which can be enumerated to quantify CIN. The assessment of CIN remains a predominantly manual and time-consuming task.

Real concerns, artificial intelligence: Reality testing for psychiatrists.

The use of augmented or artificial intelligence (AI) in healthcare promises groundbreaking advancements, from increasing diagnostic accuracy and minimizing clinical errors to personalized treatment plans and automated clinical decision-making. Its use may allow us to transition from phenomenological categories of psychiatric illness to one driven by underlying etiology and realize the Research Domain Criteria (RDoC) model proposed by the (U.S.

Neuropsychiatric and behavioral symptom clusters in frontotemporal dementia.

Background: Non-Alzheimer's disease dementias, including frontotemporal dementia (FTD) can be difficult to characterize due to the predominance of distinct behavioral and neuropsychiatric symptoms. Widely used measurement tools lack structure and objectivity.

Objective: The purpose of this study was to use systematic direct observation of neuropsychiatric and behavioral symptoms, via the Neurobehavioral Rating Scale (NBRS), to characterize clusters of behavioral and neuropsychiatric symptoms in FTD and examine how selected symptom clusters correlate with structural neuroimaging.

Pericapsular Nerve Group block in the emergency department for hip fractures: a clinical protocol.

Isolated hip fractures incur significant mortality within 1 year of operative repair. Adequate analgesia is important in maintaining functional status and facilitating recovery. A multi-modal pain management strategy incorporating regional anesthesia may decrease the need for high-dose narcotics and promote faster recovery.

Recommendations for use of extracorporeal shockwave therapy in sports medicine: an international modified Delphi study.

Objectives: While extracorporeal shockwave therapy (ESWT) may be an efficacious adjunctive treatment option for musculoskeletal injuries, current research is limited by significant heterogeneity within treatment protocols. This study aims to establish international expert consensus recommendations on ESWT terminology, parameters, procedural considerations, contraindications and side effects in the application of ESWT to sports injuries.

Methods: A systematic literature search was performed on the use of ESWT for musculoskeletal and sports medicine injuries to identify potential panellists, followed by the development of a steering committee-led questionnaire.

A Universal Approach to Educating Patients with HIV about Long-Acting Injectable Treatment for HIV.

Long-acting injectable antiretroviral treatment (LAI ART) has the potential to transform HIV care and reduce HIV-related health inequities in achieving and maintaining viral suppression. However, without a plan for equitable roll-out of LAI ART, new pharmacological innovations in HIV treatment and prevention risk further deepening health disparities. This study delineates a process for providing universal LAI ART education to people with HIV (PWH) at an urban outpatient infectious disease clinic and documents the outcomes of these efforts.

Social Protection and HIV risk Factors among Youth in Southern Africa: An Analysis of Cross-sectional Population-based HIV Impact Assessment Surveys.

Poverty fuels risky sexual behaviors associated with HIV infection among youth. Interventions like cash transfers may mitigate HIV risk. We explored the role of broader social protection (including food, educational, and social transfers) in reducing HIV risk among 15-24-year-olds in Southern Africa.

Pediatric Difficult Intravenous Access Scores in a Low-Resource Setting: An External Validation Study.

Objectives: This study aims to establish and evaluate validity data for pediatric difficult intravenous access (DIVA) scores in low-resource emergency care settings within low- to middle-income countries (LMIC). We also sought to explore associated factors for DIVA that could contribute to a modified pediatric DIVA score with optimal performance in our setting.

Methods: We performed a prospective cross-sectional study in children aged 0 to 15 years who required urgent or emergent peripheral intravenous access (PIVA) over a 10-month period in a large university hospital in Bangkok, Thailand.

Relationships of hematocrit concentration with dementia from a multiethnic population-based study.

Objective: Red blood cell (RBC) concentration impacts cerebrovascular disease, yet it is unclear whether RBC concentrations relate to dementia risk, particularly in racially/ethnically diverse cohorts. We investigated whether RBC concentrations associate with incident dementia risk in a diverse population of stroke-free individuals and explored whether cerebral small vessel disease (CSVD) mediates this relationship.

Methods: A longitudinal observational analysis was performed using a population-based cohort of stroke-free, older adult participants (>50 years) from the Northern Manhattan Study (NOMAS) enrolled between 2003 and 2008.

Healthcare Provider Strike Preparedness and Response: Lessons Learned From Physician Strikes in New York City.

Labor actions by healthcare workers are increasing in frequency and quantity, particularly throughout the United States. Regardless of their cause and size, these strikes could disrupt normal hospital operations and impact patient access to care, quality of care, and costs. Strikes resemble other large-scale incidents like natural disasters, pandemics, or terrorist attacks by shrinking a hospital's capacity to care for patients, forcing hospitals to pursue logistically complicated actions such as finding replacement providers, and impacting nearby facilities due to patient offloading.

Evaluation by dental professionals of an artificial intelligence-based application to measure alveolar bone loss.

Background: Several commercial programs incorporate artificial intelligence in diagnosis, but very few dental professionals have been surveyed regarding its acceptability and usability. Furthermore, few have explored how these advances might be incorporated into routine practice.

Methods: Our team developed and implemented a deep learning (DL) model employing semantic segmentation neural networks and object detection networks to precisely identify alveolar bone crestal levels (ABCLs) and cemento-enamel junctions (CEJs) to measure change in alveolar crestal height (ACH).

The brown fat-specific overexpression of RBP4 improves thermoregulation and systemic metabolism by activating the canonical adrenergic signaling pathway.

Retinol-binding protein 4 (RBP4), the sole specific carrier for retinol (vitamin A) in circulation, is highly expressed in liver and adipose tissues. Previous studies have demonstrated that RBP4 plays a role in cold-mediated adipose tissue browning and thermogenesis. However, the role of RBP4 in brown adipose tissue and its metabolic significance remain unclear.

Safeguarding the future of biomedical science in the United States.

NIH's abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes America's global leadership in science and medicine. Urgent action is needed to advocate for its immediate and permanent reversal to protect the future of science.

Physical and functional interactions between LDLR family members and CXCR4 in breast cancer.

C-X-C chemokine receptor type 4 (CXCR4) belongs to the seven-span G protein-coupled receptor family and plays an important role in promoting cancer metastasis. The single-span receptor, low-density lipoprotein receptor-related protein 6 (LRP6) is commonly considered to be a co-receptor of Wnt and plays an indispensable role during animal development. We recently demonstrated that LRP6 directly binds to CXCR4 via its ectodomain and prevents CXCR4-induced breast cancer metastasis.