Adsorption isotherms in roasted specialty coffee ( L.): Dataset and statistical tools for optimizing storage conditions and enhancing shelf life.

This work presents a comprehensive dataset of adsorption isotherms and infrared spectral data for roasted specialty coffee ( L.). The dataset includes adsorption isotherms for whole roasted beans and ground coffee at medium (850 µm) and fine (600 µm) particle sizes.

Mid-infrared spectra of dried and roasted cocoa ( L.): A dataset for machine learning-based classification of cocoa varieties and prediction of theobromine and caffeine content.

This paper presents a comprehensive dataset of mid-infrared spectra for dried and roasted cocoa beans ( L.), along with their corresponding theobromine and caffeine content. Infrared data were acquired using Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy, while High-Performance Liquid Chromatography (HPLC) was employed to accurately quantify theobromine and caffeine in the dried cocoa beans.

Genotoxic effects in island populations of Cartagena de Indias, Colombia due to environmental exposure to mercury and cadmium.

Background: Contamination of Cartagena Bay, Colombia with heavy metals such as mercury (Hg) and cadmium (Cd) presents a major environmental and public health concern, particularly for human communities residing on nearby islands and coastal areas. These populations face enhanced exposure risks owing to their traditional fishing practices and continuous interactions with polluted marine environments. This study aimed to evaluate the genotoxic effects of environmental exposure to Hg and Cd in populations from the island zone of the Cartagena district, Bolívar.

Mediation of anxiety and coping strategies between severe discipline and interparental conflict with parenting stress.

Parenting stress is a complex process for parents who feel that the demands of their children upbringing overwhelm their roles. Parenting stress can be associated with anxiety, parental conflict and harsh discipline practices, and the use of coping strategies that positively buffer the effect of these variables on parents. Although the factors associated with parenting stress are well documented, the literature offers few models to explain the stress and the mediation of certain variables on Colombian families.

"Doctor, I Want to Be Like This!": Exploring Global Beauty Body Standards Through a Multicenter Survey.

Background: Plastic surgery aims to enhance patients' positive features and improve perceived flaws without seeking complete transformation. The body is a living organism, not a sculptural object to be reshaped at will. Aesthetic standards are influenced by subjective factors, including technology and social media's effect on self-perception and beauty ideals.

Global perspectives on the biodegradation of LDPE in agricultural systems.

The increasing use of plastics globally has generated serious environmental and human health problems, particularly in the agricultural sector where low-density polyethylene (LDPE) and other plastics are widely used. Due to its low recycling rate and slow degradation process, LDPE is a major source of pollution. This paper addresses the problem of plastic accumulation in agriculture, focusing on LDPE biodegradation strategies.

From surface to caves: new species of Brandt, 1833 (Oniscidea, Armadillidae) from Colombia, with the description of the first troglobitic species.

Two new species of are described, from Cerro Bañaderos in Hatonuevo, La Guajira, and from Roca Madre Cave, Toluviejo, Sucre, both from the Tropical Dry Forest (TDF) areas of the Colombian Caribbean. The latter represent the first troglobitic species of the genus. Moreover, based on specimens from Sierra Nevada de Santa Marta, Magdalena (type locality), is placed into and an identification key for all species of the genus is given.

Facing migration under adverse conditions: challenges and resilience in the Colombo-Venezuelan border area.

Background: Internal displacement and cross-country migration are an increasing global phenomenon drawing the attention of politicians and the public. Causes and effects on the migrants and receptor populations are varied and often shaped by immigration laws and how migrants and refugees are being dealt with by local conditions, policy frameworks and by the host population (receptors). The massive influx of Venezuelan migrants into Colombia for more than a decade has characteristics which warrant a systematic analysis to identify contextual and individual factors favouring and hindering the well-being of migrants and their new Colombian neighbours of the receptor population.

Exploring the phytoremediation potential of plant species in soils impacted by gold mining in Northern Colombia.

Contamination of soils with toxic metals poses significant threats to human health and ecosystems. Plant-based remediation strategies can play a vital role in mitigating these risks, and the use of plants as a remediation strategy can help reduce these risks. In this study, we investigate the remediation potential of native plants in accumulating and translocating metal(loid)s at a Colombian site impacted by gold mining.

Pembrolizumab and chemotherapy in high-risk, early-stage, ER/HER2 breast cancer: a randomized phase 3 trial.

Addition of pembrolizumab to neoadjuvant chemotherapy followed by adjuvant pembrolizumab improved outcomes in patients with high-risk, early-stage, triple-negative breast cancer. However, whether the addition of neoadjuvant pembrolizumab to chemotherapy would improve outcomes in high-risk, early-stage, estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER/HER2) breast cancer remains unclear. We conducted a double-blind, placebo-controlled phase 3 study (KEYNOTE-756) in which patients with previously untreated ER/HER2 grade 3 high-risk invasive breast cancer (T1c-2 (≥2 cm), cN1-2 or T3-4, cN0-2) were randomly assigned (1:1) to neoadjuvant pembrolizumab 200 mg or placebo Q3W given with paclitaxel QW for 12 weeks, followed by four cycles of doxorubicin or epirubicin plus cyclophosphamide Q2W or Q3W.

Insights from a century of data reveal global trends in ex situ living plant collections.

Ex situ living plant collections play a crucial role in providing nature-based solutions to twenty-first century global challenges. However, the complex dynamics of these artificial ecosystems are poorly quantified and understood, affecting biodiversity storage, conservation and utilization. To evaluate the management of ex situ plant diversity, we analysed a century of data comprising 2.

CMV Reactivation Following Allogeneic Transplantation in Children From a High-Seroprevalence Population: A Single-Center Experience in Colombia.

Introduction: Cytomegalovirus (CMV) infection is a frequent complication among hematopoietic stem cell transplant (HSCT) recipients. Data regarding CMV reactivation in children in underdeveloped countries is scarce. This is especially notable considering the increasing utilization of haploidentical-related HSCT with the post-transplant cyclophosphamide platform.

Nanoparticle-based colorimetric assays for early and rapid screening of the oncogenic HPV variants 16 and 18.

Cervical cancer is predominantly caused by human papillomavirus (HPV), with oncogenic strains HPV 16 and 18 accounting for most cases worldwide. Prompt and precise identification of these high-risk HPV types is essential for enhancing patient outcomes as it enables timely intervention and management. However, the existing HPV detection techniques are time-consuming, expensive, and require highly skilled personnel.

[Estado nutricional de pacientes pediátricos con deficiencia predominantemente de anticuerpos].

Unlabelled: Introducción. La deficiencia predominantemente de anticuerpos es el grupo de errores inmunólogicos innatos más frecuente, sin embargo, hay poca información sobre el estado nutricional de los pacientes afectados.

Objetivo: Caracterizar el estado nutricional de pacientes colombianos con deficiencias predominantemente de anticuerpos.

Intra-mesenteric steroids for steroid-refractory graft-versus-host disease in pediatric patients: A safe option.

Introduction: Graft-versus-host disease is a serious complication after hematopoietic stem cell transplantation and is a major cause of death post-transplantation. Approximately 50% of acute graft-versus-host disease patients do not respond to systemic steroids and their prognosis is poor regardless of the treatment. This study describes our experience with pediatric patients diagnosed with steroid-refractory graft-versus-host disease who received intra-mesenteric steroid treatment.

Severe immunodeficiency spectrum associated with NHEJ1 gene mutation: Cernunnos/XLF deficiency.

Cernunnos/XLF deficiency is a rare, severe combined immunodeficiency, inherited in an autosomal recessive pattern (OMIM number: 611290), related to the NHEJ1 gene. This gene participates in the DNA non-homologous end-joining pathway, repairing double-strand breaks in the DNA of mammalian cells. The clinical features include growth retardation, microcephaly, triangle-shaped face, recurrent infections, fibroblast's excessive sensitivity to gamma-ionizing radiation, and hypogammaglobulinemia; also, low counts of subpopulations of B and T lymphocytes, with normal values of natural-killer cells.

[Recomendaciones sobre vacunación en niños y adolescentes con errores innatos de la inmunidad según el programa ampliado de inmunización colombiano].

En el presente manuscrito se presenta un análisis exhaustivo de las recomendaciones mundiales sobre inmunización en pacientes con errores innatos de la inmunidad. Se examinaron los mecanismos de acción y los tipos de vacunas, y se describieron las vacunas incluidas en el Plan Ampliado de Inmunización (PAI) colombiano y las pautas específicas para la inmunización de pacientes con los errores innatos de la inmunidad más frecuentes en Colombia. Estas recomendaciones se ajustaron según la gravedad y la subclasificación de cada inmunodeficiencia, teniendo en cuenta las variaciones en la respuesta inmunitaria, con el objetivo de ofrecer recomendaciones basadas en la evidencia clínica para la vacunación de niños con estas condiciones.

Lymphoproliferation and hyper-IgM as the first manifestation of activated phosphoinositide 3-kinase δ syndrome: A case report.

Activated phosphoinositide 3-kinase δ syndrome is an inborn error of immunity due to mutations within the genes responsible for encoding PI3Kδ subunits. This syndrome results in an excessive activation of the phosphoinositide 3-kinase signaling pathway. Gainof-function mutations in the gene PIK3R1 (encoding p85α, p55α, and p50α) lead to the development of the activated PI3K δ syndrome.

Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia.

Introduction: Non-cystic fibrosis bronchiectasis is a complex medical condition with multiple etiologies, characterized by chronic productive cough and radiologic evidence of airway lumen dilation and wall thickening. Associated exacerbations and declining lung function contribute to increasing disability and mortality. There are no data about the prevalence of non-cystic fibrosis bronchiectasis etiologies in the Colombian population.

[Primera parte. Hombre de 45 años con neumonía grave, infección diseminada por citomegalovirus y agammaglobulinemia].

Se trata de un paciente de sexo masculino de 45 años con tos persistente de cuatro meses de duración, acompañada de fiebre y una significativa pérdida de peso. En la tomografía de tórax, se observó una neumonía idiopática y los estudios posteriores identificaron una carga viral positiva para citomegalovirus (CMV) en el lavado broncoalveolar. La biopsia transbronquial confirmó inclusiones basófilas intranucleares indicativas de la infección por CMV.

[Un enemigo oculto: tratando de entender el síndrome hemofagocítico en niños menores de 5 años en una institución de alta complejidad del suroccidente de Colombia].

Introducción. El síndrome hemofagocítico es una condición poco reconocida, pero con gran mortalidad en la población pediátrica. Se caracteriza por la activación excesiva de células inmunitarias y la liberación de citocinas, lo cual causa inflamación persistente.

From phenotypic to molecular diagnosis: Insights from a clinical immunology service focused on inborn errors of immunity in Colombia.

Introduction: Inborn errors of immunity include a broad spectrum of genetic diseases, in which a specific gene mutation might alter the entire emphasis and approach for an individual patient.

Objective: To conduct a comprehensive analysis of the correlation between phenotypic and molecular diagnoses in patients with confirmed inborn errors of immunity at a tertiary hospital in Cali, Colombia.

Materials And Methods: We conducted a retrospective study in which we sequentially evaluated all available institutional medical records with a diagnosis of inborn errors of immunity.

[Bronquiectasias no relacionadas con fibrosis quística en pediatría: perfil de una cohorte de pacientes con errores innatos de la inmunidad en un centro de referencia de Cali, Colombia].

Introducción. Los errores innatos de la inmunidad se asocian frecuentemente con bronquiectasias. Actualmente, el diagnóstico de los errores innatos de la inmunidad ha mejorado porque se conoce con certeza la asociación de estas entidades con el daño progresivo de las vías respiratorias.

Haploidentical hematopoietic stem cell transplantation using post-transplant cyclophosphamide in patients with inborn errors of immunity: Experience in a reference center in Colombia.

Introduction: Inborn errors of immunity is a diverse group of rare diseases caused by over 400 genetic mutations affecting the immune system and increasing infection susceptibility, autoimmunity, and malignancy. Hematopoietic stem cell transplantation offers a curative option for some inborn errors of immunity, with haploidentical donors providing a viable alternative when identical donors are unavailable.

Objective: To determine survival, usefulness of weekly chimerism monitoring, immune reconstitution, and complications in patients with inborn errors of immunity who underwent haploidentical hematopoietic stem cell transplantation at a reference center in Colombia.