Bilateral Choroidal Metastases from Primary Cutaneous Melanoma Following Nivolumab Discontinuation: A Case Report.

Purpose: To present the case of a young patient with BRAF V600E-mutant cutaneous melanoma who developed bilateral choroidal metastases complicated by neovascular glaucoma (NVG) in both eyes following the interruption of nivolumab therapy.

Methods: A 28-year-old female with primary cutaneous melanoma of the left hand underwent surgical resection and adjuvant nivolumab. Immunotherapy was discontinued due to immune-related acute interstitial nephritis.

Genotyping Genebank Collections: Strategic Approaches and Considerations for Optimal Collection Management.

The maintenance of plant germplasm and its genetic diversity is critical to preserving and making it available for food security, so this invaluable diversity is not permanently lost due to population growth and development, climate change, or changing needs from the growers and/or the marketplace. There are numerous genebanks worldwide that serve to preserve valuable plant germplasm for humankind's future and to serve as a resource for research, breeding, and training. The United States Department of Agriculture (USDA) National Plant Germplasm System (NPGS) and the Consultative Group for International Agricultural Research (CGIAR) both have a network of plant germplasm collections scattered across varying geographical locations preserving genetic resources for the future.

Potential Effect of Cinnamaldehyde on Insulin Resistance Is Mediated by Glucose and Lipid Homeostasis.

Diabetes mellitus is a metabolic syndrome that has grown globally to become a significant public health challenge. Hypothesizing that the plasma membrane protein, transient receptor potential ankyrin-1, is a pivotal target in insulin resistance, we investigated the mechanism of action of cinnamaldehyde (CIN), an electrophilic TRPA1 agonist, in skeletal muscle, a primary insulin target. Specifically, we evaluated the effect of CIN on insulin resistance, hepatic glycogen accumulation and muscle and adipose tissue glucose uptake.

Application of Post-Industrial Leather Waste for the Development of Sustainable Rubber Composites.

The substantial waste generated during the processing of hides and skins as well as at other stages of manufacturing is a recurring issue in the leather industry that this article attempts to address. To investigate the mechanical and thermal characteristics of the resultant composites, this study suggests using leather waste from the bovine leather industry, analyzes the tanning process, and assesses the viability of mixing this waste with natural rubber (TSR-20). Without the inclusion of leather waste, the resulting composites had exceptional tensile strength, surpassing 100% of rubber's strength.

Risk Factors Associated with Hemoparasites in Dual-Purpose Cattle of Colombia.

Hemoparasitic diseases represent a significant problem with a considerable impact on tropical and subtropical areas of the world. These conditions cause economic losses associated with multi-organic failure and even the death of animals. In these areas, the hemoparasites are transmitted in an enzootic cycle when infectious cattle, such as persistently infected animals, including cows, contribute to the success of transmission.

High Prevalence of spp. in Ready-to-Eat Artisanal Pork Sausages Sold at Food Outlets in Quindío, Colombia.

Non-typhoidal salmonellosis is a foodborne disease caused by spp. Most outbreaks of this disease are commonly associated with consuming contaminated meat products, hence the importance of monitoring ready-to-eat artisanal pork sausages for the presence of these bacteria. A total of 494 samples of grilled and smoked barbecue artisanal pork sausages were collected at food outlets from 12 municipalities of the Department of Quindío, Colombia, between 2017 and 2022.

In Vivo Imaging of Cardiac Attachment of TcI and TcII Variants of in a Zebrafish Model.

, the etiological agent of Chagas disease, is a parasite known for its diverse genotypic variants, or Discrete Typing Units (DTUs), which have been associated with varying degrees of tissue involvement. However, aspects such as parasite attachment remain unclear. It has been suggested that the TcI genotype is associated with cardiac infection, the most common involved site in chronic human infection, while TcII is associated with digestive tract involvement.

Image-Based Detection and Classification of Malaria Parasites and Leukocytes with Quality Assessment of Romanowsky-Stained Blood Smears.

Malaria remains a global health concern, with 249 million cases and 608,000 deaths being reported by the WHO in 2022. Traditional diagnostic methods often struggle with inconsistent stain quality, lighting variations, and limited resources in endemic regions, making manual detection time-intensive and error-prone. This study introduces an automated system for analyzing Romanowsky-stained thick blood smears, focusing on image quality evaluation, leukocyte detection, and malaria parasite classification.

Evolution of the Quality of Care in Patients with Decompensated Heart Failure in a Venezuelan Hospital.

Several parameters have been proposed for the objective measurement of the quality of care (QoC) and breaches of care in patients with heart failure (HF). Therefore, the objective of this study was to evaluate the measures of QoC in inpatients with decompensated HF in the cardiology department of a tertiary Venezuelan hospital. : An observational, descriptive, ambispective study was conducted with adults of all genders diagnosed with decompensated HF between 2022 and 2024.

Specialized Metabolite Profiling-Based Variations of Watercress Leaves ( R.Br.) from Hydroponic and Aquaponic Systems.

Watercress (), a freshwater aquatic plant in the Brassicaceae family, is characterized by its high content of specialized metabolites, including flavonoids, glucosinolates, and isothiocyanates. Traditionally, commercial cultivation is conducted in submerged beds using river or spring water, often on soil or gravel substrates. However, these methods have significant environmental impacts, such as promoting eutrophication due to excessive fertilizer use and contaminating water sources with pesticides.

Exploring Natural Deep Eutectic Solvents (NADES) for Enhanced Essential Oil Extraction: Current Insights and Applications.

Essential oils (EOs) are highly valued in the cosmetic and food industries for their diverse properties. However, traditional extraction methods often result in low yields, inconsistent compositions, lengthy extraction times, and the use of potentially harmful solvents. Natural deep eutectic solvents (NADES) have emerged as promising alternatives, offering advantages such as higher efficiency, cost-effectiveness, biodegradability, and tunable properties.

Histology Assessment of Chitosan-Polyvinyl Alcohol Scaffolds Incorporated with CaO Nanoparticles.

Scaffolds for regenerative therapy can be made from natural or synthetic polymers, each offering distinct benefits. Natural biopolymers like chitosan (CS) are biocompatible and biodegradable, supporting cell interactions, but lack mechanical strength. Synthetic polymers like polyvinyl alcohol (PVA) provide superior mechanical strength and cost efficiency but are not biodegradable or supportive of cell adhesion.

Influence of Environmental Factors on the Aboveground Biomass of Mature and Postmining Forests in Chocó.

Environmental factors control the accumulation of aboveground biomass (AB) in tropical forests, along with the role of AB in climate change mitigation. As such, the objective of this study was to evaluate the influence of factors such as forest type, succession, abundance of individuals, species richness, height, diameter, texture, and soil nutrient levels on the AB in mature and postmining forests in Chocó, Colombia. Five plots each were set up in primary and postmining forests with 15 and 30 years of regeneration, in which the amount of AB was measured and related to the environmental factors.

Efficacy of Telerehabilitation Protocols for Improving Functionality in Post-COVID-19 Patients.

Background And Aims: Telerehabilitation is essential for the recovery of post-COVID-19 patients, improving exercise tolerance, dyspnea, functional capacity, and daily activity performance. This study aimed to describe telerehabilitation protocols specifically designed for individuals with post-COVID-19 sequelae.

Materials And Methods: A systematic review was conducted with registration number CRD42023423678, based on searches developed in the following databases: ScienceDirect, Scopus, Dimensions.

Optimisation of Using Low-Grade Kaolinitic Clays in Limestone Calcined Clay Cement Production (LC3).

LC3 (limestone calcined clay cement) is poised to become the construction industry's future as a so-called low-carbon-footprint cement. Research into this subject has determined the minimum kaolinite content in calcined clays to guarantee good mechanical performance. This study examines the use of clay from the Valencian Community (Spain), which has a lower kaolinite content than the recommended amount (around 30%) for use in LC3 and how its performance can be enhanced by replacing part of that clay with metakaolin.

Analysis of Porosity-Water/Binder Index for Prediction of Strength and Stiffness of Cemented Sands: A Comparative Study.

Artificial sand cementation improves stability, stiffness, and mechanical strength, making it a critical process in geotechnical applications. This study analyzes the capability of the porosity-water/binding agent index (ηCw/Biv) to predict cemented sands' unconfined compressive strength (qu) and stiffness (Go). Four Colombian sands, i.

Searching for More Effective Food Baits for Tephritid Fruit Flies (Diptera: Tephritidae): Performance of Newly Developed Vial-Lures Relative to Torula Yeast Borax.

Food-baited traps are an important part of early detection programs for invasive tephritid fruit fly species, as they are attractive to both sexes of all targeted species. Torula yeast borax (TYB) mixture is a standard food bait, but its longevity is limited (1-2 weeks). Synthetic food-based lures have been developed, including ammonium acetate, putrescine, and trimethylamine.

Heat Stress in Dairy Cows: Impacts, Identification, and Mitigation Strategies-A Review.

Heat stress in animals affects productivity, health, and reproduction, with particularly pronounced effects in dairy cows. Identifying heat stress requires understanding both physiological and environmental indicators, such as increased heart rate, respiratory rate, and rectal temperature, which reflect the animal's thermal condition within its environment. Thermoregulation in cows involves behavioral and physiological adjustments to maintain homeothermy, aiming to stabilize their internal thermal state.

Periodontal Indices as Predictors of Cognitive Decline: Insights from the PerioMind Colombia Cohort.

: Poor oral health and periodontitis have been epidemiologically linked to cognitive decline and mild cognitive impairment (MCI) in older adults. However, specific metrics directly linking these clinical signs are exceedingly limited. : To address this gap and develop novel tools to help clinicians identify individuals at risk of cognitive decline, we established the PerioMind Colombia Cohort, comprising elderly Colombian subjects who underwent comprehensive neurocognitive and periodontal evaluations.

Climate Change and Health: A Study of the Attitudes of Future Science Teachers.

Living beings as open systems depend on climate and weather to survive. However, changes in the Earth's climatology, which have become more frequent since the industrial period, have affected different territories of the planet, limiting access to ecosystem services and causing imbalances in health and well-being. The first purpose of this study is to conduct a literature review on academic production regarding climate change and its impact on health, in the context of education, using international academic production condensed in the Web of Science (WOS) database over the last 10 years as a reference.

Quality of life in idiopathic pulmonary fibrosis in Latin American countries.

Background: Idiopathic pulmonary fibrosis (IPF) is the most common Interstitial Lung Disease (ILD). It is characterized by dyspnoea and a progressive decline in lung function, which negatively affects life. This study aimed to evaluate Health-Related Quality of Life (HRQoL) in IPF patients in Latin American countries.

Occurrence of Chiorchis fabaceus (Trematoda: Cladorchiidae) in a wild Antillean manatee (Trichechus manatus manatus): New parasitological data for this imperilled sirenian.

Parasites impact wildlife populations and ecosystem health, thereby demanding regular monitoring. As part of the national conservation effort to preserve the free-ranging sirenians in Colombia, a parasitological survey was conducted between 2011 and 2023 on naturally deceased Antillean manatees (Trichechus manatus manatus). A total of 17 stranded carcasses were analysed for the occurrence of parasites.

Cytotoxicity and genotoxicity of zinc oxide nanoparticles in human peripheral blood mononuclear cells.

Zinc oxide nanoparticles (ZnO-NPs) are of interest in biomedical applications, environmental remediation, and agriculture. ZnO-NPs inhibit the growth of phytopathogenic fungi and bacteria. We have evaluated their effects on mitochondrial function and the induction of membrane damage, apoptosis, and DNA damage in human peripheral blood mononuclear cells (PBMC) in vitro.

Development of edible films based on sweet potato (Ipomoea batatas) starch and their application in candy packaging.

Recent studies have focused on the generation of biomaterials from natural sources, highlighting the use of starch from different sources to obtain edible films and coatings. In this study, edible films were developed from sweet potato starch, and their potential use in candy packaging was evaluated. Films were prepared by the casting method, and the effects of sweet potato starch (3 %-5 % w/w), glycerol (0.