A clinicopathological comparison of community-based and clinic-based cohorts of patients with dementia.

Objectives: To compare the sensitivity and specificity of the clinical diagnosis of Alzheimer disease, the distribution of pathological causes, and the demographic and clinical characteristics of 2 different groups of patients with dementia.

Design: Retrospective clinicopathological study.

Setting: A memory disorder clinic in a university hospital and a multiethnic community.

Low-density lipoprotein cholesterol and the risk of dementia with stroke.

Context: Next to Alzheimer disease, vascular dementia is the second most common form of dementia in the elderly, yet few specific risk factors have been identified.

Objective: To investigate the relationship of plasma lipids and lipoproteins to dementia with stroke.

Design And Setting: Prospective longitudinal community-based study over a 7-year period (1991-1998).

The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics.

Context: Although the association between Alzheimer disease (AD) and the apolipoprotein E epsilon4 (APOE-epsilon4) allele has been confirmed worldwide, it appears to be inconsistent among African Americans, Hispanics, and Nigerians.

Objective: To investigate the association between the APOE-epsilon4 allele and AD in elderly African Americans, Hispanics, and whites.

Design: Prospective, population-based, longitudinal study over a 5-year period (1991-1996).