1 results match your criteria: "College of Pharmacy The University of Texas at Austin Austin Texas USA.[Affiliation]"
Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles.
Bioeng Transl Med
November 2023
Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy The University of Texas at Austin Austin Texas USA.
Although mRNA lipid nanoparticles (LNPs) are highly effective as vaccines, their efficacy for pulmonary delivery has not yet fully been established. A major barrier to this therapeutic goal is their instability during aerosolization for local delivery. This imparts a shear force that degrades the mRNA cargo and therefore reduces cell transfection.
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