1,783 results match your criteria: "College of Oriental Medicine[Affiliation]"

Purpose: The aim of this study was to investigate the efficacy of ethanol extracts of (ECA) against benign prostatic hyperplasia (BPH) and .

Materials And Methods: The prostate stromal cells (WPMY-1) and epithelial cells (RWPE-1) were used to examine the action mechanism of ECA in BPH . ECA efficacy was evaluated using a testosterone propionate (TP)-induced BPH rat model.

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Leaf extract of promotes anti-heat stress and antioxidant effects in .

Front Pharmacol

March 2024

Center of Excellence Research for Melioidosis and Microorganisms (CERMM), Walailak University, Nakhon Si Thammarat, Thailand.

has been used for traditional medicines, healthy foods and tea. The chemical compositions and biological activities of fruit, stem bark and root have been widely studied. However, the phytochemical components and the biological activities in leaves (GAL) are limited.

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Background: Jiuwan decoction has been used to treat chronic eczema since the Qing Dynasty. According to clinical experience, Shizhenqing granules (SZQG), derived from the Jiuwan decoction, exert beneficial clinical effects on acute eczema and reduce recurrence. Therefore, we elucidated the underlying mechanisms of SZQG through network pharmacology, molecular docking, and experimental validation.

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Particulate matter stimulates the NADPH oxidase system via AhR-mediated epigenetic modifications.

Environ Pollut

April 2024

Department of Biochemistry, College of Medicine, and Jeju Research Center for Natural Medicine, Jeju National University, Jeju, 63243, South Korea. Electronic address:

Article Synopsis
  • Particulate matter (PM) can make skin cells called keratinocytes produce reactive oxygen species (ROS), which are harmful molecules that can damage cells.!* -
  • The study found that this ROS production happens through a system involving specific proteins called NOX1, NOX4, and DUOX1, as well as calcium signaling.!* -
  • The particles also interact with a receptor called AhR, which helps turn on the genes for NOX1 and DUOX1, leading to more ROS being made in skin cells.!*
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Bisphenol A (BPA), an exogenous endocrine-disrupting chemical, is widely used to produce polycarbonate plastics. The widely used BPA has been detected in human urine samples, raising public anxiety about the detrimental effects of BPA on the bladder. In this study, we explored regulatory mechanisms for the adverse effects of BPA in human bladder BdFC and T24 cells.

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Aim: Lithospermum erythrorhizon and Pueraria lobata exhibit promising potential as cosmetic additives for mitigating skin barrier impairment induced by photoaging. Despite their potential, the precise mechanisms underlying their protective and ameliorative effects remain elusive. This study sought to assess the reparative properties of Lithospermum erythrorhizon and Pueraria lobata extracts (LP) on UVB-irradiated human skin keratinocytes (HaCaT cells) and explore the therapeutic potential of LP as a skin barrier protection agent.

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(Cleft Lip and Palate Transmembrane Protein 1-Like) has previously been implicated in tumorigenesis and drug resistance in cancer. However, the genetic link between and bladder cancer remains uncertain. In this study, we investigated the genetic association of variable number of tandem repeats (VNTR; minisatellites, MS) regions within with bladder cancer.

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Purpose: T1 high grade (T1HG) bladder cancer (BC) is a type of non-muscle invasive BC (NMIBC) that is recognized as an aggressive subtype with a heightened propensity for progression. Current risk stratification methods for NMIBC rely on clinicopathological indicators; however, these approaches do not adequately capture the aggressive nature of T1HG BC. Thus, new, more accurate biomarkers for T1HG risk stratification are needed.

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Sibjotang Protects against Cardiac Hypertrophy In Vitro and In Vivo.

Life (Basel)

December 2023

Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, 460, Iksan-daero, Iksan, Jeonbuk 54538, Republic of Korea.

Cardiac hypertrophy is developed by various diseases such as myocardial infarction, valve diseases, hypertension, and aortic stenosis. Sibjotang (, Shizaotang, SJT), a classic formula in Korean traditional medicine, has been shown to modulate the equilibrium of body fluids and blood pressure. This research study sought to explore the impact and underlying process of Sibjotang on cardiotoxicity induced by DOX in H9c2 cells.

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Article Synopsis
  • A study in South Korea analyzed fibromyalgia treatment trends from 2011 to 2018 using national health insurance data, focusing on patient demographics and treatment approaches.
  • The research found that visits to internal medicine departments increased significantly, while rates of non-pharmacological treatments like physical therapy and acupuncture declined.
  • Prescription rates for analgesics, relaxants, and antidepressants grew, with non-steroidal anti-inflammatory drugs showing the highest increase, and women tended to have longer prescription durations and higher medication combination rates.
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Although tamoxifen (TAM) is widely used in patients with estrogen receptor-positive breast cancer, the development of tamoxifen resistance is common. The previous finding suggests that the development of tamoxifen resistance is driven by epiregulin or hypoxia-inducible factor-1α-dependent glycolysis activation. Nonetheless, the mechanisms responsible for cancer cell survival and growth in a lactic acid-rich environment remain elusive.

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Human endogenous retrovirus (HERV)-K was reportedly inserted into the human genome millions of years ago and is closely related to various diseases, including cancer and immune regulation. In our previous studies, CRISPR-Cas9-enabled knockout (KO) of the HERV-K gene was found to potentially reduce cell proliferation, cell migration, and invasion in colorectal and ovarian cancer cell lines. The immune response involves the migration and invasion of cells and is similar to cancer; however, in certain ways, it is completely unlike cancer.

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Purpose: Massage therapy is an important adjunctive treatment for physiologic and psychologic symptoms and has been shown to benefit patients among a wide variety of patient populations.

Setting: Few studies have investigated the utility of massage therapy in the general ICU setting, and even fewer have done so in the neurological ICU (NeuroICU).

Research Design: If massage therapy was determined to improve objective outcomes-or even subjective outcomes in the absence of harm-massage may be more readily employed as a complementary therapy, particularly in the ICU setting or in patients with acute neurological injury.

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Article Synopsis
  • The antioxidative proteolytic fraction, MA-1, was purified and shown to have significantly increased specific activity (89-fold) while retaining 42.5% of its activity during purifying processes.
  • MA-1 demonstrated stability in the presence of various metal ions and solvents, while exhibiting a chymotrypsin-like specificity for certain substrates and optimal activity at a temperature of 40 °C and pH of 5.5.
  • This enzyme also showed strong fibrinolytic activity, capable of hydrolyzing fibrinogen chains, and displayed an antithrombotic effect in animal studies without causing hemorrhagic complications, suggesting its potential in cardiovascular disease prevention.
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Background: Cough-variant asthma (CVA), a precursor of typical asthma, is the main cause of chronic cough. We hypothesize that yukmijihwang-tang (YJT), which has been used for chronic cough in traditional medicine and has been reported to have an anti-inflammatory effect, could be an adjuvant to asthma treatment.

Methods: We plan a randomized, double-blind, placebo-controlled, multicenter, phase 2 trial to investigate the efficacy and safety of YJT in CVA patients.

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Asthma is a chronic inflammatory disease of the pulmonary system associated with many wheeze-to-sleep apnea complications that may lead to death. In 2019, approximately 262 million patients suffered from asthma, and 455 thousand died from the disease worldwide. It is a more severe health problem in children and older adults, and as the aging of society intensifies, the problem will continue to worsen.

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Dohongsamul-tang inhibits cardiac remodeling and fibrosis through calcineurin/NFAT and TGF-β/Smad2 signaling in cardiac hypertrophy.

J Ethnopharmacol

January 2024

Hanbang Cardio-renal Research Center & Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, South Korea; College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, South Korea. Electronic address:

Article Synopsis
  • Dohongsammul-tang (DH) is a traditional Korean herbal medicine known for alleviating symptoms from blood stagnation and protecting against cardiovascular issues.
  • The study aims to investigate DH's potential in reducing cardiac hypertrophy, which is a condition that thickens the heart due to pressure overload, ultimately affecting heart health.
  • The methodology involved creating a concentrated DH extract from six herbal components, which was then tested in a surgical model inducing pressure overload to evaluate its effects on cardiac injury and fibrosis.
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  • The text discusses a traditional herbal medicine used in China and Europe for treating digestive issues like indigestion and bloating.
  • It explores the mechanism through which this herbal remedy alleviates functional dyspepsia using network pharmacology and animal models.
  • The findings highlight seven specific compounds that target key genes related to functional dyspepsia, indicating a potential treatment method that enhances gastrointestinal motility.
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  • The study evaluated the effectiveness of BT stem extract for treating gout (hyperuricemia) and potential cosmetic benefits, identifying active ingredients like caffeic acid and luteolin.
  • Different extraction methods revealed that hot water extraction yielded the most product, while 80% ethanolic extract had the highest antioxidant activity, yet 100% ethanol exhibited strong enzyme inhibitory effects.
  • The findings suggest BT stem extract could be a valuable natural remedy for gout and skin issues, prompting the need for additional research on extraction optimization and effectiveness in practical applications.
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Climate change is one of the most important threats to farmed abalone worldwide. Although abalone is more susceptible to vibriosis at higher water temperatures, the molecular mode of action underlying this has not been fully elucidated. Therefore, this study aimed to address the high susceptibility of Halitotis discus hannai to V.

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Purification of phenoloxidase from Haliotis discus hannai and its anti-inflammatory activity in vitro.

Fish Shellfish Immunol

June 2023

Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554 Republic of Korea; Department of Biomedicine, Health & Life Convergence Sciences, BK21 Four, Biomedical and Healthcare Research Institute, Mokpo National University, Jeonnam, 58554, Republic of Korea. Electronic address:

Article Synopsis
  • Haliotis discus hannai, a protein-rich food popular in Asia, has antioxidant, anticancer, and antibacterial properties, prompting research into its hemolymph.
  • The study focused on purifying a protein called phenoloxidase (PO) and examining its effects on human colonic cells, revealing that PO could reduce harmful bacteria-derived lipopolysaccharides without being toxic to the cells at certain concentrations.
  • Increased levels of PO decreased inflammatory responses in cells exposed to lipopolysaccharides by regulating certain cytokines and signaling pathways, indicating its potential role in managing inflammation in the gastrointestinal tract.
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Ethnopharmacological Relevance: The cause of irritable bowel syndrome (IBS), a functional gastrointestinal (GI) disorder, remains unclear. Banhasasim-tang (BHSST), a traditional herbal medicines mixture, mainly used to treat GI-related diseases, may have a potential in IBS treatment. IBS is characterized by abdominal pain as the main clinical symptom, which seriously affects the quality of life.

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Network Pharmacological Analysis and Experimental Validation of the Effect of on Gastrointestinal Motility Disorder.

Plants (Basel)

March 2023

Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.

Gastrointestinal motility disorder (GMD) is a disease that causes digestive problems due to inhibition of the movement of the gastrointestinal tract and is one of the diseases that reduce the quality of life of modern people. (SGR) is a traditional herbal medicine for many diseases and is sometimes prescribed to improve digestion. As a network pharmacological approach, we searched the TCMSP database for SGR, reviewed its constituents and target genes, and analyzed its relevance to gastrointestinal motility disorder.

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Background: Prostate cancer is the second most common cause of cancer death worldwide in men. The development of novel and highly efficient therapeutic strategies is strongly recommended to treat prostate cancer. Cyperaceae are an ecologically and economically important family of plants with several pharmacological effects.

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Background: The aim of the present study is to confirm the efficacy, safety, and cost-effectiveness of thread-embedding acupuncture (TEA) in the treatment of adhesive capsulitis (AC).

Methods: This is a randomized, sham-controlled, patient-assessor blinded trial with two parallel arms in a 1:1 ratio. A total of 160 participants with AC, also known as frozen shoulder, will be recruited and screened according to the eligibility criteria.

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