Protocol for the development of an intervention to improve the use of Point-of-caRE DiagnostICs in the management of respiraTOry tRact infectionS in primary care (the PREDICTORS study).

Background: Antimicrobial resistance is a significant global health challenge, exacerbated by inappropriate antibiotic prescribing, particularly in primary care where up to 50% of antibiotic prescriptions prescribed by general practitioners (GPs) and dispensed by community pharmacists (CPs) are deemed inappropriate. Respiratory tract infections (RTIs) are among the most common conditions leading to GP consultations and subsequent antibiotic prescribing, much of which is inappropriate as most RTIs are viral in nature or self-limiting bacterial infections. Point-of-care tests (POCTs) have emerged as tools to improve the diagnosis and appropriate treatment of RTIs.

The Relationship Between Perceived Self-Efficacy and Resilience Among Pediatric Nurses in Eastern Province of Saudi Arabia.

Purpose: This study examines the relationship between the perceived levels of resilience and self-efficacy among a selected sample of pediatric nurses working in the Eastern province of Saudi Arabia.

Patients And Methods: A descriptive, cross-sectional, correlational design was used. A total of 99 pediatric nurses from two governmental hospitals in the Eastern Province of Saudi Arabia completed an online survey which included two standardized measures: The Brief Resilience Scale (BRS) and the General Self-Efficacy Scale (GSE).

The Interaction Between Family Functioning and the rs9540720 Polymorphism on Major Depressive Disorder in Chinese Freshmen.

Objective: Unhealthy family functioning and Protocadherin 9 () have been recognized as potential environmental and genetic risk factors for major depressive disorder (MDD). This study examined the effects of the interaction between and family functioning on MDD in first-year university students.

Methods: A cohort of 6985 first-year university students in China was established in 2018 and was followed for one year.

Quality of Life of Children with Idiopathic Nephrotic Syndrome.

Background: Nephrotic syndrome (NS) is relapsing-remitting illness affecting children and characterized by proteinuria, edema, and hypoalbuminemia. The disease involves the significant formative years of a child's life and profoundly impacts their physical and psychosocial well-being. There is a scarcity of literature exploring the quality of life (QoL) of children with NS and the factors influencing them.

Effects of empathy on the perspectives of respectful and disrespectful maternity care among nursing and midwifery students in China: A cross-sectional study.

Background: Empathy is a crucial attribute in healthcare, benefiting both professionals and patients. It also plays an important role in the midwife-woman relationship, contributing to the implementation of respectful maternity care. Witnessing acts of disrespect towards childbearing women in the clinical setting may impair students' perceptions of respectful maternity care, as they may come to view disrespect as normative.

Adipose derived mesenchymal stem cell-seeded regenerated silk fibroin scaffolds reverse liver fibrosis in mice.

Liver fibrosis (LF) is an important process in the progression of chronic liver disease to cirrhosis. We have previously demonstrated that a regenerated silk fibroin scaffold loaded with adipose-derived stem cells (RSF + ADSCs) can repair acute liver injury. In this study, we established a chronic LF animal model using carbon tetrachloride (CCl) and a high-fat diet.

Feasibility Study of Using Electronic Patient-Reported Outcomes to Screen Patients with Advanced Solid Cancers for Palliative Care Needs.

Palliative care delivery in oncology is challenging and referral practices vary widely. Standardized, needs-based screening and triage systems are essential to more effectively address patients' palliative care needs. Assess the feasibility, acceptability, and appropriateness among patients with advanced solid cancers of using electronic patient-reported outcomes (ePROs) to screen for palliative care needs.

Family Involvement During Patient Hospitalisation-Developing and Testing a Clinical Decision Aid.

Background: The rising prevalence of multi-morbidity increases treatment complexity and caregiving demands, often necessitating involvement of family members as informal caregivers. While essential, this involvement can be burdensome, causing distress for family members. Shared decision-making facilitates communication and supports the alignment of patients' and families' preferences and needs with care and treatment decisions.

Mpox: exploring the nursing role in diagnosis, management and controlling its spread.

Mpox, previously known as monkeypox, is a viral disease that has become a significant global health concern following outbreaks beyond its endemic regions in central and west Africa. In 2022, the World Health Organization declared a 'public health emergency of international concern' (PHEIC) due to a rise in mpox cases, predominantly affecting gay and bisexual men. Although the initial surge of cases had diminished by early 2023, a new PHEIC was declared in 2024 due to a more severe strain of the virus circulating in the Democratic Republic of the Congo.

Accuracy of Pressure Injury Risk Assessment Tools in Paediatrics: A Systematic Review and Network Meta-Analysis.

Aim: To evaluate the accuracy of different pressure injury risk assessment tools in paediatrics and identify risk assessment tools with the best predictive performance.

Design: A systematic review and network meta-analysis.

Methods: Eight electronic databases, including PubMed, Embase, Web of Science, Cochrane Library, China Knowledge Resource Integrated Database, Weipu Database, Wanfang Database and Chinese Biomedical Database were comprehensively searched.

Video-Based Climate Change Program Boosts Eco-Cognizance, Emotional Response and Self-Efficacy in Rural Nursing Students: Randomised Controlled Trial.

Background: The Munich Security Conference 2024 highlighted the complex connections between climate change and global security risks. Engaging students in fighting climate change is a stepping stone to achieving the Sustainable Development Goals.

Aim: To investigate the effect of a video-based climate change program on revitalising eco-cognizance, emotional response, and self-efficacy among nursing students in rural communities.

Association between workplace social capital and occupational injuries and illnesses: A 1-year prospective cohort study.

Objectives: This study aimed to examine the relationship between workplace social capital (WSC), and occupational injuries and illnesses.Methods: A prospective cohort study was conducted using a questionnaire-based survey in Japan. Overall WSC and its subtypes were divided into three categories (lower, intermediate, and higher).

Using Natural Language Processing in the LACE Index Scoring Tool to Predict Unplanned Trauma and Surgical Readmissions in South Africa.

Background: Unplanned and potentially avoidable readmission within 30 days post discharge is a major financial burden.

Aim: To use text-based electronic patient records to calculate the Charlson Comorbidity Index (CCI) score using a natural language processing technique to establish the feasibility and usefulness of the text-based electronic patient records in identifying patients at risk for unplanned readmission.

Methods: A retrospective review of electronic patient records for general and trauma surgery in a hospital in South Africa (2012-2022) was conducted using the LACE score.

Insights Into the Caregiver Experience for Pediatric Patients With Sickle Cell Disease in Saudi Arabia: Demographic Profiles, Care Recipient Characteristics, and Subjective Well-Being.

Objective: This study aimed to examine the demographic characteristics of informal caregivers of pediatric patients with sickle cell disease. The background characteristics of both caregivers and care recipients were analyzed, and the informal care situation was examined. Additionally, this study aimed to quantify the economic impact of care.

Comparison of MyDispense with in-person simulation in drug information training of pharmacy curriculum - a randomized cross-over study.

Background: Drug information training is restricted to pharmacy students due to the lack of opportunities for training and the inadequate number of drug information centers. Drug information simulation requires manpower and is time-consuming to arrange. MyDispense (MD) is widely accepted by numerous pharmacy schools and plays a major role in training students for various courses in the pharmacy curriculum.

Effect of oral ligustrazine phosphate with cerebroside carnosine on neurological function and serum inflammatory factors among patients with ischemic cerebrovascular disease: a quasi-experimental study.

Objectives: To explore the effect of ligustrazine phosphate tablets combined with cerebroside carnosine on neurological function and serum inflammatory factors among patients with ischemic cerebrovascular disease.

Methods: This was a quasi-experimental study. From March 2019 to February 2022, 126 patients were non-randomly divided into control (n = 63) and intervention (n = 63) groups.

Effects of at-risk alcohol use on nighttime blood pressure, urinary catecholamines, and sleep quality in midlife adults.

Background: The association between alcohol and hypertension has been predominantly based on office blood pressure (BP) measurements. However, little is known about the effect of alcohol use on nighttime BP and the underlying mechanisms. The purpose of this study was to investigate the effects of at-risk alcohol use on nighttime BP, urinary catecholamines, and sleep quality in midlife adults.

Factors Associated With Pain Among Hospitalized Older Adults Living With Dementia.

Purpose: The purpose of this study was to consider the factors associated with change in function, physical activity, behavioral symptoms and participation in function focused care among hospitalized older adults living with dementia.

Design: This was a secondary data analysis using data from the Function Focused Care for Acute Care Using the Evidence Integration Theory (FFC-AC-EIT) study to increase physical activity among hospitalized older adults living with dementia.

Methods: A total of 455 patients were recruited from 12 hospitals across two states.

Diagnostic Performance of Artificial Intelligence Based on Biparametric MRI for Clinically Significant Prostate Cancer: A Systematic Review and Meta-analysis.

Objectives: This meta-analysis aimed to systematically evaluate the diagnostic performance of artificial intelligence (AI) applied to biparametric magnetic resonance imaging (bpMRI) for identifying clinically significant prostate cancer (csPCa).

Methods: A comprehensive systematic review was conducted following PRISMA-DTA guidelines, searching PubMed, Embase, and Web of Science databases. Studies focus on AI algorithms based on bpMRI in diagnosis csPCa were included.

Racial and Ethnic Disparities in Accessing High-Quality Home Health Care Among Older Adults With and Without Dementia.

Objectives: Home health care (HHC) plays a pivotal role in serving millions of US adults aging in place. Although the HHC population is growing rapidly in both size and diversity, driven by an aging US population and a changing demographic profile, there are increasing concerns of equity in HHC, particularly regarding how vulnerable populations are affected under current HHC practices. The purpose of this study was to examine the variations in accessing high-quality HHC in racial and ethnic minority groups and persons living with dementia.

Voluntary wheel exercise improves learning and memory impairment caused by hippocampal Hb-α deficiency by reducing microglial activation and reversing synaptic damage.

Decreased hemoglobin (Hb) levels in peripheral blood may be a risk factor for Alzheimer's disease (AD). Hb-α is a monomeric form of Hb that exists in the central nervous system. Our previous RNA sequencing results revealed a decrease in the expression of the Hb-α gene in the hippocampus of AD model mice.

Use of automated room disinfection systems in the healthcare environment: A national survey.

Background: Automated room disinfection systems (ARDSs) have been increasingly adopted worldwide to address emerging infectious diseases and antibiotic-resistant bacteria.

Aim: This study aims to assess the current use of ARDSs in acute healthcare settings across South Korea.

Methods: A nationwide online survey was conducted in 150 tertiary general hospitals.

Shared decision making with older people on treatment escalation planning for acute deterioration in the emergency medical setting: a UK-based qualitative study of patient perspectives (STREAMS-P).

Background: Shared decision making (SDM) in treatment escalation planning (TEP) involves patients and clinicians determining together a contingency for future health deterioration. Patients' role in health-care decision making is subject to ongoing debate. This study aimed to understand the perspectives of older patients in the UK on SDM in TEP for the acute hospital setting.

Harnessing machine learning for predicting successful weaning from mechanical ventilation: A systematic review.

Background: Machine learning (ML) models represent advanced computational approaches with increasing application in predicting successful weaning from mechanical ventilation (MV). Whilst ML itself has a long history, its application to MV weaning outcomes has emerged more recently. In this systematic review, we assessed the effects of ML on the prediction of successful weaning outcomes amongst adult patients undergoing MV.