343 results match your criteria: "College of Natural and Applied Sciences[Affiliation]"

Annual consumption rate of fish types in Tanzania's Singida municipality during 2022.

Heliyon

January 2025

Department of Geography and Environmental Studies, College of Natural and Applied Sciences, Sokoine University of Agriculture, P. O. Box 3038, Morogoro, Tanzania.

This study assessed the annual fish consumption among the households in Singida Municipality. This was due to the long-time of unsatisfactory pupil performance in joining secondary schools which may be linked to a lack of Long-chain omega-3 polyunsaturated fatty acids. The study used a questionnaire based on a random household consumer survey of 204 households.

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Advancing Equity and Empowering Science Students from Indigenous Communities.

Anal Chem

January 2025

Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta Canada, T6G 2G3.

Implementation of Diversity, Equity, Inclusion, and Respect (DEIR) is crucial for supporting students in a culturally safe environment, reducing bias, fostering respect, broadening perspectives, enhancing collaboration, and improving education in science. DEIR with Indigenous reconciliation incorporates Indigenous-based DEIR initiatives as a response to the Truth and Reconciliation Commission (TRC) in Canada to acknowledge the intergenerational trauma and mistrust toward colonial institutions such as universities. Universities can advance reconciliation by incorporating DEIR with Indigenous reconciliation into everyday practices.

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The asymmetric Schiff base prepared from ethylenediamine and pyridine-2-carboxaldehyde reacts with Fe(ClO)·6HO to form the Fe(II) complex [FeL](ClO) with L = ,-diethyl-'-(pyridin-2-yl)methylene)ethane-1,2-diamine, where the Fe(III) starting material has been unexpectedly reduced to Fe(II). This complex was characterized by elemental analysis, infrared spectra, single crystal and powder X-ray diffraction measurements, variable temperature DC magnetic measurement and room temperature Mössbauer spectroscopy. The asymmetric ligand L coordinates in a tridentate fashion through its pyridyl, azomethine and amino nitrogen atoms, generating a distorted octahedral geometry around the central metal ion.

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Article Synopsis
  • Heavy metal pollution poses serious health and environmental risks due to toxic metals being persistent in different ecosystems.
  • Advances in sensor technology have enhanced real-time detection and monitoring methods, using innovative tools like immobilized chromogenic reagents, nanomaterials, perovskites, and nanozymes.
  • The review delves into each technique's strengths and limitations while exploring trends in hybrid systems that utilize multiple approaches for improved effectiveness in heavy metal detection.
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Wastewater contamination by organic dyes, especially Rhodamine B (RhB), possess a significant environmental challenge. This study explores a novel bio sorbent for the removal of RhB dye from contaminated water, using chitosan trisodium citrate-modified magnetic nanoparticles (Fe₃O₄@CSTSC@PANI) coated with polyaniline. The nanocomposite was characterized by FT-IR, XRD, HRTEM, SEM, BET surface analysis.

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Borderline oxacillin-resistant (BORSA) has been a persistent yet under-researched concern in the realm of antibiotic resistance, characterized by unique resistance mechanisms and potential for severe infections. This systematic review and meta-analysis consolidates data from 29 studies encompassing 18,781 samples, revealing a global BORSA prevalence of 6.6% (95% CI [4.

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Computational analysis of Urolithin A as a potential compound for anti-inflammatory, antioxidant, and neurodegenerative pathways.

Free Radic Biol Med

December 2024

School of Life Science and Bioengineering, The Nelson Mandela African Institution of Science and Technology, P.O. Box 447, Arusha, Tanzania. Electronic address:

Urolithin A, an active precursor derived from the metabolism of ellagitanins in rats and humans, is known for its potential health benefits, including stimulating mitophagy and promoting muscular skeletal function. While experimental studies have demonstrated Urolithin A's potential to enhance cellular health, the detailed molecular interactions through which Urolithin A exerts its effects are not fully elucidated. In this study, we investigated the anti-inflammatory, antioxidation and neuroprotective abilities of Urolithin A in selected targets using molecular docking and molecular dynamics simulation methods.

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Anthropogenic activities along the Lake Nyasa catchments alter the habitat and genetic diversity of a Lake Salmon, .

Heliyon

October 2024

Department of Chemistry and Physics, College of Natural and Applied Sciences, Sokoine University of Agriculture, P. O. Box 3038, Morogoro, Tanzania.

Article Synopsis
  • * A study analyzing genetic diversity using mitochondrial COI sequences and microsatellite loci found lower genetic diversity in areas impacted by human activities compared to more pristine locations.
  • * The findings suggest that human actions are negatively affecting the genetic diversity of Lake Salmon, highlighting the need for immediate conservation measures to protect this species and other aquatic life from extinction.
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The traditional medicinal value of (turmeric) and its potential relevance in modern healthcare suggests that traditional remedies and natural products can provide valuable solutions to contemporary challenges, such as combating biofilms and antibiotic-resistant pathogens, potentially offering new strategies for addressing health and safety issues in the fields of food and medicine. This study assessed the antibiofilm and antibacterial characterization of Curcuma longa rhizome extract against antibiotic-resistant foodborne pathogens. Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier-transform infrared (FTIR) analysis were determined to check for the compounds, functional groups, and constituents of the plant extract.

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  • PfRh5 has shown promise as a malaria vaccine candidate due to its key role in merozoite invasion and overall stability, with recent trials indicating its safety and effectiveness.
  • A study was conducted in Tanzanian regions known for high malaria transmission to assess genetic variation and immune responses to PfRh5 in asymptomatic carriers, revealing some new mutations but overall genetic conservation.
  • Results indicated variable immune response sensitivity tied to age, with the findings highlighting the importance of ongoing monitoring of vaccine efficacy and antigenic variation to improve malaria vaccine development.
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Cereal crops have been integral to human sustenance since the Neolithic era which have earned significant attention as staple foods. The year-round cultivation and consumption of cereal-based products have led to the escalating global production of cereals and a rise in industrial processing which results in significant waste generation. These wastes contain high-value nutrients such as carbohydrates, proteins, and lipids.

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The Ribbontail stingray is an economically important fish and attractive species for the aquarium trade industry. Overfishing, habitat degradation, and pollution, however, pose a threat to this species. This study used partial mitochondrial cytochrome oxidase subunit I (COI) sequences (603 base pairs long) from 96 samples of collected at five fish-landing sites (Deep Sea-Tanga, Malindi-Unguja, Kaole-Bagamoyo, Kivukoni-Dar es Salaam, and Bandarini-Mtwara) located along the coast of Tanzania to determine the species' genetic diversity, population genetic structure, and demographic history.

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First reported cases of Borrelia and dengue co-infection: A case series.

Trop Biomed

September 2024

Department of Medical Microbiology and Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia.

Article Synopsis
  • Dengue fever is a common illness in tropical countries, often diagnosed in patients with acute fever, while Borrelia is linked to infections like Lyme disease and relapsing fever.
  • This report presents the first case series of patients co-infected with dengue and Borrelia in Malaysia, highlighting that all three had typical dengue symptoms but no severe complications.
  • Despite detecting Borrelia DNA in their blood, the patients did not show signs of skin lesions or insect bites, and they responded well to treatment with intravenous fluids, being discharged after a few days.
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Prevalence of carbapenem-resistant (CRE) in Saudi Arabia: A systematic review and meta-analysis.

Saudi Pharm J

November 2024

Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.

Article Synopsis
  • * The analysis reviewed 69 eligible studies out of 787 records and found significant resistance rates to key carbapenem antibiotics, with highest resistance reported for ertapenem (up to 34.2%) in recent years.
  • * The findings highlight the urgent need for improved infection control strategies and ongoing surveillance to combat rising antibiotic resistance and protect public health.
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Global prevalence patterns and distribution of Vibrio cholerae: A systematic review and meta-analysis of 176,740 samples.

J Infect Public Health

November 2024

Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital USM, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address:

This global systematic review and meta-analysis of Vibrio cholerae prevalence, covering environmental, food, animal, and human samples, analysed 111 studies from five databases. The meta-analysis, adhering to standard reporting guidelines, revealed a pooled prevalence of 10.6 % (95 % CI; 8.

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Background: Lung cancer ranks as one of the most rapidly growing malignancies. Which is characterized by its poor prognosis and a low survival rate due to late diagnosis and limited efficacy of conventional treatments. In recent years nanotechnology has emerged as a promising frontier in the management of lung cancer, presenting novel strategies to enhance drug administration, improve therapeutic efficiency, and mitigate side effects.

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The Interaction of Myeloperoxidase with the Industrial Contaminant 6-PPD: A Potential Pathway for Reactive Metabolites.

Chem Res Toxicol

October 2024

Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.

6-PPD (-[1,3-dimethylbutyl]-'-phenyl--phenylenediamine) is an industrial antioxidant reported to be an environmental contaminant. It was found to be highly toxic to coho salmon and potentially other aquatic organisms. The toxicity of 6-PPD in humans, however, remains unknown.

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Article Synopsis
  • Epilepsy is a major public health issue in Tanzania, particularly in Mahenge, where stigma and misconceptions significantly impact the lives of affected individuals.
  • A study involving 778 participants revealed that while most were aware of epilepsy, their knowledge was low, leading to negative attitudes and misconceptions about the disorder's causes, such as witchcraft and hereditary factors.
  • Stigma towards individuals with epilepsy was prevalent, resulting in social isolation and barriers to education, with traditional healers often being the first point of treatment despite the lack of understanding of the condition.
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The Chemistry and Pharmacological Properties of the Constituents of Toussaintia Orientalis - An Endangered Treasure of Biomedical Agents.

Chempluschem

January 2025

Department of Chemistry, College of Natural and Applied Sciences, University of Dar es Salaam, P.O Box 35061, Dar es Salaam, Tanzania.

Toussaintia orientalis Verdc. (Annonaceae) is a medicinal plant species endemic to Tanzania. It is classified under the International Union for Conservation of Nature (IUCN) as an extremely endangered species threatened with extinction.

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This research explores the antimicrobial resistance (AMR) profiles and prevalence of extended-spectrum beta-lactamase (ESBL) and non-ESBL-producing Escherichia coli in Ojerame Dam and Ovokoto Spring, Edo State, Nigeria. Over 12 months, water was systematically sampled to accommodate seasonal variations and analyzed by employing an ESBL-selective medium for bacterial species. Additionally, bacterial isolates underwent identification and characterization using polymerase chain reaction (PCR) and disk diffusion methods to evaluate their susceptibility to antimicrobials.

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Effect of High Glucose on Embryological Development of Zebrafish, , through Wnt Pathway.

Int J Mol Sci

August 2024

Biology Department, School of Physical Sciences and Engineering, Anderson University, 1100 5th Street, Anderson, SC 29621, USA.

Gestational diabetes mellitus (GDM) is a worldwide pregnancy complication. Gestational diabetes can significantly impact fetus development. However, the effects of high glucose on embryological development post-fertilization are yet to be researched.

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Article Synopsis
  • The study investigates the link between Onchocerca volvulus (causing onchocerciasis) and epilepsy in Mahenge, Tanzania, focusing on the prevalence of both conditions after 25 years of ivermectin treatment.
  • A cross-sectional survey of 56,604 individuals was conducted, revealing onchocerciasis prevalence among children at 11.8%, higher in medium-altitude villages, and epilepsy incidence at 21.1 cases per 1,000 persons, also more prevalent in medium altitudes.
  • Female gender, middle altitudes, and positive OV16 antibodies were associated with a higher likelihood of having epilepsy, highlighting ongoing public health challenges despite long-term ivermectin use.
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Treasures in our backyard: unleashing the biotechnological potentials of endophytic fungi from Tanzanian mangroves.

Nat Prod Res

September 2024

Department of Molecular Biology and Biotechnology, College of Natural and Applied Sciences, University of Dar es Salaam, Dar es Salaam, Tanzania.

Endophytic fungi are useful in a variety of biological processes and may find value in pharmaceutical settings. However, there hasn't been much research done on the bioactive compounds produced by mangrove fungal endophytes from the East African coast. Our previous research revealed a significant number of mangrove endophytic fungi in Dar es Salaam, Tanzania.

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Article Synopsis
  • - Soil-transmitted helminthiases (STH) affect over 24% of the global population, prompting the WHO to suggest regular monitoring to assess treatment effectiveness and develop control strategies.
  • - In a study conducted in 2021 in northwestern Tanzania, researchers found that 56.2% of school children aged 6 to 14 were infected with STH, with some experiencing moderate-intensity infections.
  • - Key risk factors for STH included having a farming mother and not washing hands with soap; meanwhile, proper handwashing after toilet use was identified as an effective preventive measure against STH infections.
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Objectives: The rise in Carbapenem-resistant (CRE) is perturbing. To curb the menace of CRE, a comprehensive understanding of its prevalence and epidemiology is crucial. As varying reports abound, the true prevalence of CRE in Nigeria remains unknown.

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