Effects of Peanut Shell Flavonoids on Composite Film Properties and Cherry Tomato Preservation.

This study investigated the effects of varying concentrations of peanut shell flavonoids (PSFs) on the properties of peanut meal extract-tilapia skin protein composite films and their impact on cherry tomatoes preservation. Peanut meal alcohol extract (Pe) and tilapia skin protein (Co) were used as base materials, combined with PSFs to prepare composite films with excellent antioxidant properties. The results demonstrated that the optimized composite films exhibited superior mechanical properties, with a tensile strength of 9.

Pediatric uveitis.

Up to 10% of uveitis cases occur in children, with notable implications due to the risk of chronicity and vision loss. It can result from infections, autoimmune and autoinflammatory diseases, trauma, or masquerade syndromes. Primary care providers are vital in early detection, symptom management, and timely specialist referral.

Empowering youth and ensuring health: utilization of youth friendly service among preparatory school students in Gambella, Southwest Ethiopia.

Background: Youth is a period with exposure to high risk of reproductive health (RH) problems. Despite, several strategies designed to solve these problems, youths are experiencing unsafe abortion, unintended pregnancy, and sexually transmitted infections (STIs) so far. The utilization of Youth Friendly Services (YFS) and its determinants has not been well studied in Gambella so far.

Contextual and psychosocial factors associated with latrine utilization in rural communities in Ethiopia.

Background: Although proper latrine utilization is one of the best ways to reduce the risk of infection, it remains a challenge in the majority of rural communities in developing countries such as Ethiopia. Studies have demonstrated the link between individual behavior and latrine use, but there is a paucity of evidence on individual risk perception, perceived social pressure norms, social identity, and perceived ability, which plays an indubitable role in health and behavior change, especially in rural communities.

Objective: This study aimed to identify contextual and psychosocial factors associated with latrine utilization among rural communities in Lomabosa district, Ethiopia.

Challenges of maternity continuum of care within the primary health care in northwest Ethiopia: interpretive description using a socio-ecological model.

Background: The maternity continuum of care plays a vital role in improving maternal and neonatal outcomes. However, its uptake remains low in Ethiopia, highlighting the need to identify challenges within the primary health care system to inform practice. Hence, this study aimed to explore the challenges of the maternity continuum of care within the primary health care system in northwest Ethiopia.

Assessment of Pregnant Women's Satisfaction With the Model of Care Initiative: Antenatal Care Services at Primary Health Care Centers in the Qassim Health Cluster, Saudi Arabia.

Background:  Patient satisfaction is a critical indicator of healthcare quality, including high-quality antenatal care (ANC), and it directly impacts care continuity and health outcomes. This study assessed the satisfaction levels of pregnant women with ANC services provided at primary healthcare centers (PHCs) within the Qassim Health Cluster, Saudi Arabia.

Methods:  A cross-sectional survey was conducted among 646 pregnant women attending ANC services in the Qassim region.

Individual- and community-level factors associated with early initiation of breastfeeding in Mozambique: evidence from the 2022-2023 Demographic and Health Survey.

Background: Early initiation of breastfeeding is defined as giving breast milk to the newborn within one hour of birth. It strengthens the link between mother and child, promotes cognitive development, and lowers the chance of obesity and non-communicable diseases during the prime years of life. Nowadays, only 50% of newborns worldwide receive breast milk within their first hour of life.

"This is how we do it" Maternal and fetal anesthetic management for fetoscopic myelomeningocele repairs: the Texas Children's Fetal Center protocol.

Prenatal repair of myelomeningocele (MMC) is associated with lower rates of hydrocephalus requiring ventriculoperitoneal shunt and improved motor function when compared with postnatal repair. Efforts aiming to develop less invasive surgical techniques to decrease the risk for the pregnant patient while achieving similar benefits for the fetus have led to the implementation of fetoscopic surgical techniques. While no ideal anesthetic technique for fetoscopic MMC repair has been demonstrated, we present our anesthetic approach for these repairs, including considerations for both the pregnant patient and the fetus.

Hyperbaric Oxygen Therapy Improved Neovascularisation Following Limb Ischaemia-The Role of ROS Mitigation.

Hyperbaric oxygen (HBO) therapy has emerged as a potential treatment, shown to enhance blood flow and angiogenesis. However, specific effects and mechanisms of HBO on limb ischaemia responding to a hypoxic environment remain largely unknown. We aimed to investigate the therapeutic potential of HBO in the treatment of limb ischaemia.

Exploring prevention and control mechanisms of youth substance use: a case of North Wollo and Waghimra, Northeast Ethiopia.

Background: Substance use among youths is a significant global and local issue. Youth who engage in substance use often experience various psychosocial, health, economic, and other problems. While governmental and non-governmental organizations in North Wollo and Waghimra Zones offer social services, their effectiveness in preventing and controlling substance use remains largely unstudied.

Biochemical profiles of patients with COVID-19 during the first and second waves in Ethiopia.

Coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by severe acute respiratory syndrome coronavirus 2. Nasopharyngeal swabs (NP swabs) were used for patients with COVID-19 who demonstrated serious clinical symptoms and disturbances in biochemical parameters. The biochemical profiles of these patients remain ambiguous and differ from wave to wave of COVID-19 infections.

DNA aptamers that modulate biological activity of model neurons.

There is an urgent need for agents that promote health and regeneration of cells and tissues, specifically to treat diseases of the aging nervous system. Age-associated nervous system degeneration and various diseases are driven by many different biochemical stresses, often making it difficult to target any one disease cause. Our laboratory has previously identified DNA aptamers with apparent regenerative properties in murine models of multiple sclerosis by selecting aptamers that bind oligodendrocyte membrane preparations.

Prevalence of Diabetic Foot Ulcer and Determinant Factors Among Adult Diabetic Patients Who Attend the Diabetic Follow-Up at Adwa General Hospital, Ethiopia, 2019: A Cross-Sectional Study.

Background And Aims: Diabetic foot ulcers are the main complication of diabetes mellitus. There is limited information on the prevalence and factors of diabetic foot ulcers in Ethiopia, particularly to the study setting. The study aimed to assess the prevalence of diabetic foot ulcers and determinant factors among adult diabetic patients who attend the diabetic follow-up at Adwa General Hospital, Ethiopia, 2019.

Cervical Cancer Screening Practice and Associated Factors Among School Teachers in Bahir Dar City, North West Ethiopia: A Cross-Sectional Study.

Background And Aims: Despite its prioritization by the World Health Organization, improving access to cervical cancer screening remains a challenge in Ethiopia. Educated individuals, particularly teachers, are viewed as key influencers in promoting healthy lifestyles among youth and can significantly contribute to cervical cancer prevention. However, there is a notable gap in research regarding cervical cancer screening practices among female educators in the studied region.

Paving the way for quality assured, decentralised point-of-care testing for infectious disease in primary care - Real world lessons from remote Australia.

Introduction: Decentralized molecular testing for infectious disease diagnosis at the point-of-care (POC) is critical to address inequities in access to timely, informed health care. The COVID-19 pandemic accelerated the demand, development and adoption of POC tests for infectious diseases globally. This has provided opportunities to maximize the individual benefits and public health impact of POC testing, particularly in remote and resource-limited primary care settings.

Trend and forecast of measles disease, in East Gojjam Zone, Amhara Region, Northwest Ethiopia, 2023: a crossectional study.

Background: Measles is a very contagious illness that can be clinically diagnosed and intervened quickly. It is caused by the measles virus Morbillivirus. The disease has a case fatality rate of 5% to 10% in the sub-Saharan region.

Assessment of knowledge, attitude and practice towards rabies and associated factors among household heads in Welkait district, Ethiopia.

Background: Rabies is an important worldwide viral zoonotic disease with a high fatality rate and substantial socioeconomic losses. There is limited information about the community's knowledge, attitude and practice towards rabies disease in the study area. Therefore, this study was intended to assess knowledge, attitude, and practice (KAP) and associated factors towards rabies among the community in Welkait district, Northwest Ethiopia.

T lymphocyte plasticity in chronic inflammatory diseases: The emerging role of the Ikaros family as a key Th17-Treg switch.

T helper (Th) 17 and regulatory T (Treg) cells are highly plastic CD4 Th cell subsets, being able not only to actively adapt to their microenvironment, but also to interconvert, acquiring mixed identity markers. These phenotypic changes are underpinned by transcriptional control mechanisms, chromatin reorganization events and epigenetic modifications, that can be hereditable and stable over time. The Ikaros family of transcription factors have a predominant role in T cell subset specification through mechanisms of transcriptional program regulation that enable phenotypical diversification.

The Caregiver Pathway Intervention Can Contribute to Reduced Post-Intensive Care Syndrome Among Family Caregivers of ICU Survivors: A Randomized Controlled Trial.

Objectives: Explore short-term effects of "The Caregiver Pathway," an intervention for family caregiver follow-up, on Post-Intensive Care Syndrome symptoms among families (PICS-F).

Design: A randomized controlled trial.

Setting: A medical ICU at a Norwegian University Hospital.

Does cognitive intra-individual variability predict change in everyday functioning performance in women with and without HIV in the Women's Interagency HIV Study?

This study examined the association between cognitive intra-individual variability (IIV), a non-mean-based indicator of underlying neuropathology, and self-reported everyday functioning of 1,086 women with HIV (WWH) and 494 socio-demographically similar women without HIV (WWoH). Objective cognitive performance across seven domains and the self-rated Lawton & Brody scale of Instrumental Activities of Daily Living (IADL) were assessed among participants of the Women's Interagency HIV Study. Two types of cognitive IIV were calculated by taking the standard deviation across seven cognitive domains to calculate dispersion: 1) intra-individual standard deviation (denoted as IIV) and 2) coefficient of variation (denoted as IIV).

Corrigendum to "Prevalence, drug susceptibility pattern and associated factors of Mycobacterium tuberculosis infection among prisoners in western Arsi zonal prisons, Oromia, South West Ethiopia".

[This corrects the article DOI: 10.1016/j.ijregi.

Total Hip Arthroplasty, via Direct Anterior Approach, With Contralateral Proximal Femur Amputation.

Lower limb amputation has been well characterized in the literature to cause resultant osteoarthritis in the hip of the contralateral limb. This further amplifies the already significant physical disability and morbidity that come with lower limb amputation. The use of total hip arthroplasty (THA) in patients with lower limb amputations is rare, with available literature subsequently also limited.

Impact of a nurse practitioner-led dedicated outpatient parenteral antibiotic therapy clinic on patient outcomes and administrative workload: a retrospective cohort study.

Background: Outpatient parenteral antibiotic therapy (OPAT) enhances patient safety, improves outcomes, and reduces healthcare costs by decreasing 30-day readmissions and adverse events. However, the optimal structure and follow-up protocols for OPAT programs remain undefined. Identifying high-risk patients for readmission and managing adverse drug events (ADEs) are critical components of OPAT care.

Therapeutic controversies over use of antioxidant supplements during cancer treatment: a scoping review.

Background: Antioxidant supplements are widely used during cancer treatment to prevent oxidative stress, reduce treatment toxicities, and improve patient outcomes. However, current literature reveals significant gaps suggesting that antioxidants may protect both healthy and tumor cells from oxidative damage, thereby reducing treatment efficacy. It is for this reason that antioxidant supplements have become a source of therapeutic controversy.