6 results match your criteria: "College of Medicine and Life Sciences University of Toledo[Affiliation]"
J Am Heart Assoc
February 2023
Background Hypertension is associated with gut dysbiosis, altered intestinal immunity, and gut pathology in animal models and humans. Although these findings have implicated impaired interactions between gut and gut microbiota in hypertension, little is known about the specific functional gut microbes that interact with intestinal mucosa. Methods and Results To identify these microbes, we sorted Immunoglobin A (IgA)-coated (IgA) and IgA-noncoated (IgA) bacteria using a combination of magnetic-activated cell sorting and fluorescence-activated cell sorting, and subsequently performed 16 S rRNA gene sequencing (IgA-SEQ) to determine the microbial composition of IgA and IgA fractions in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats.
View Article and Find Full Text PDFJ Am Heart Assoc
December 2022
Program in Physiological Genomics, Center for Hypertension and Precision Medicine, Department of Physiology and Pharmacology, College of Medicine and Life Sciences University of Toledo OH.
Background The gut and gut microbiota, which were previously neglected in blood pressure regulation, are becoming increasingly recognized as factors contributing to hypertension. Diseases affecting the gut such as inflammatory bowel disease (IBD) present with aberrant energy metabolism of colonic epithelium and gut dysbiosis, both of which are also mechanisms contributing to hypertension. We reasoned that current measures to remedy deficits in colonic energy metabolism and dysbiosis in IBD could also ameliorate hypertension.
View Article and Find Full Text PDFAm J Case Rep
October 2022
Department of Medical Education/Neurosciences, College of Medicine and Life Sciences University of Toledo, Toledo, OH, USA.
BACKGROUND Hyperostosis frontalis interna is a boney overgrowth of the inner side of the frontal bone of the skull caused by overgrowth of the endocranial surface. It is most often found in women after menopause. It is also associated with hormonal imbalance, being overweight, history of headaches, and neurocognitive degenerative conditions.
View Article and Find Full Text PDFFront Neurol
October 2020
ProMedica Neurosciences Center, Toledo, OH, United States.
Multiple risk factors of mortality have been identified in patients with COVID-19. Here, we sought to determine the effect of a history of neurological disorder and development of neurological manifestations on mortality in hospitalized patients with COVID-19. From March 20 to May 20, 2020, hospitalized patients with laboratory confirmed or highly suspected COVID-19 were identified at four hospitals in Ohio.
View Article and Find Full Text PDFPharmacol Res Perspect
August 2019
Department of Cancer Biology, College of Medicine and Life Sciences University of Toledo Toledo Ohio.
The sodium pump (Na/K-ATPase) is a plasma membrane enzyme that transports Na and K against their physiological gradients in most eukaryotic cells. Besides pumping ions, the enzyme may also interact with neighboring proteins to activate cell signaling pathways that regulate cell growth. Digitalis drugs, useful for the treatment of heart failure and atrial arrhythmias, inhibit the pumping function of Na/K-ATPase and stimulate its signaling function.
View Article and Find Full Text PDFHepatol Commun
January 2018
Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences University of Toledo Toledo OH.
Exenatide, a glucagon-like peptide-1 receptor agonist, induces insulin secretion. Its role in insulin clearance has not been adequately examined. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance to maintain insulin sensitivity.
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