A standardised measurement and valuation scale of genomic utility for policy decisions: the GUV-scale.

Objectives: The multifaceted ways in which genomics can be valuable to clinicians, patients, families, and society are important for informing prioritisation decisions by policy makers. This study aims to develop a standardised, cumulative and preference-weighted Genomic Utility Valuation (GUV) on a scale 0-100%.

Methods: A multicriteria decision analysis (MCDA) was conducted with experts involved in policy, clinical, research, and consumer advocacy leadership in Australia for the valuation of policy priority indicators of genomic utility.

Comparisons of approaches to pelvic floor muscle training for urinary incontinence in women.

Background: Pelvic floor muscle training (PFMT) is a recommended treatment for female stress, urgency, and mixed urinary incontinence. Training varies in exercise type (pelvic floor muscles contracting with and without other muscles), dose, and delivery (e.g.

The Australian clinical trial landscape: Perceptions of rural, regional and remote health service capacity and capability.

Background: Access to clinical trials is limited for rural, regional and remote Australians, adding to the current health inequity between rural and metropolitan populations. The Australasian Teletrial Model was developed to bring clinical trials "closer to home". In 2020, the Australian Teletrial Program was funded to expand and support the uptake of the model across six Australian states and territories.

Effect of aging on the translucency of lithium disilicate and zirconia reinforced lithium silicate ceramics: An study.

Background: Translucency of dental ceramics have great impact on the esthetic and success of dental restorations. The goal of the study is to investigate the effect of the aging process on the translucency of zirconia-reinforced lithium silicate ceramic material, and lithium disilicate ceramic material made using CAD/CAM and press processes.

Methods: Thirty disc-shaped specimens with 0.

Hyperkalaemia among hospital admissions: prevalence, risk factors, treatment and impact on length of stay.

Background: Hyperkalaemia is one of the common electrolyte disorders among hospital patients, affected by many risk factors including medications and medical conditions. Prompt treatment is important given its impact on patient mortality and morbidity, which can lead to negative patient outcomes and healthcare resource utilisation. This study aims to describe the prevalence, characteristics, and treatment of patients admitted to hospitals with hyperkalaemia and compare findings between patients with kidney failure on maintenance haemodialysis therapy and patients without kidney failure.

Congenital Insensitivity to Pain and Anhidrosis With Orthopedic and Self-Injury Complications in a 5-Year-Old Boy: A Case Report.

Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder because of NTRK1 gene mutations, leading to an inability to perceive pain and temperature and lack of sweating. Its rarity and unique clinical challenges, such as severe injuries from the inability to sense pain, make reporting cases critical. A 5-year-old boy, the third child of consanguineous parents, was referred for a fractured femur.

Orthopedic Devices for Skeletal Class III Malocclusion Treatment in Growing Patients: A Comparative Effectiveness Systematic Review.

Skeletal Class III malocclusion (Cl III) presents a significant orthodontic challenge, particularly in growing patients, requiring interceptive treatment to achieve effective functional and aesthetic correction. This review aims to compare various orthopedic devices and therapeutic protocols used in Cl III correction, identifying the most effective options in an interceptive context. We searched the PubMed, Scopus, and Web of Science databases for studies published between 1 January 2003, and 19 July 2023.

Analysis of microbiota in black stain of children and its impact on caries risk. A systematic review.

Black stain (BS) is a peculiar discoloration often observed on the teeth of paediatric patients, particularly prevalent in certain populations. This systematic review aims to analyze the composition of the microbiota associated with BS and its potential implications for caries risk. A acomprehensive search was conducted across multiple databases (PubMed, Scopus, Web of Science) to identify relevant studies published up to January 2024.

Guided Bone Regeneration: CGF and PRF Combined With Various Types of Scaffolds-A Systematic Review.

Bone regeneration plays a pivotal role in modern oral surgery, particularly in facilitating successful implant-prosthetic rehabilitation. This systematic review explores the regenerative potential of growth factors, such as platelet-rich fibrin (PRF) and concentrated growth factors (CGFs), when combined with various types of scaffolds in bone augmentation procedures, including guided bone regeneration, split crest, sinus lift (SL), and alveolar ridge preservation. A comprehensive search strategy yielded 18 relevant studies, which were analyzed for bone formation and stabilization outcomes.

Trends of HIV/AIDS in Pregnant Women Presenting to a Tertiary Care Setting.

According to WHO, there are around 35 million adults living with HIV/AIDs worldwide. Of these, around 1.5 million are pregnant women.

Blurred vision: The ophthalmological effect of smog in Pakistan.

This article discusses the growing burden of smog in Pakistan, tracing its origins to vehicular emissions, industrial pollutants, and agricultural practices. It highlights current national initiatives and advocates for enhanced government interventions to mitigate smog's adverse effects on ocular health. It also emphasizes the need for collective action to safeguard ocular health amid rising smog pollution in Pakistan.

Effect of introduction of intermittently scanned continuous glucose monitoring on glycaemic control in individuals living with type 2 diabetes mellitus treated with non-insulin therapies-A randomised controlled trial.

Aims: This pilot randomised controlled trial aimed to evaluate the effect of introducing isCGM on glycaemic control and diabetes distress in individuals with T2DM receiving non-insulin therapies.

Materials And Methods: Forty adults with T2DM were randomised to either receive FreeStyle Libre 2 (Libre 2), an isCGM system, or FreeStyle Libre Pro iQ (Libre Pro) also known as 'blinded' CGM. Participants were followed for 12 weeks.

Comparative analysis of deep learning algorithms for dental caries detection and prediction from radiographic images: a comprehensive umbrella review.

Background: In recent years, artificial intelligence (AI) and deep learning (DL) have made a considerable impact in dentistry, specifically in advancing image processing algorithms for detecting caries from radiographical images. Despite this progress, there is still a lack of data on the effectiveness of these algorithms in accurately identifying caries. This study provides an overview aimed at evaluating and comparing reviews that focus on the detection of using DL algorithms from 2D radiographs.

Determination of the Late Postmortem Interval by Observing the Electrical Conductivity in Skeletal Muscles of Rats.

Objective: To determine the values of electrical conductivity (EC) of cadaveric skeletal muscles of male rats and their relationship with different postmortem intervals (PMI).

Study Design: Experimental study. Place and Duration of the Study: Department of Forensic Medicine and Toxicology, King Edward Medical University (KEMU), Lahore, in collaboration with the University of Veterinary and Animal Sciences (UVAS) Lahore, from October 2021 to September 2022.

The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review.

Background: Polynucleotides (PN), popular in biorevitalization, show promise in the current sphere of esthetic medicine due to their regenerative properties, previously used in wound healing. Currently, research investigates their use in esthetic medicine. The aim of this review was to synthesize the existing literature, focusing on the effectiveness of PN in esthetic medicine, which is concentrated on skin rejuvenation by providing patients with multiple benefits and the least side effects.

Mentor-Mentee relationship in Medicine: How to develop trust?

A mentor-mentee relationship, also known as a mentoring relationship, is a professional or personal partnership in which a more experienced or knowledgeable individual (the mentor) provides guidance, support, and advice to a less experienced or knowledgeable individual (the mentee). The primary purpose of this relationship is to facilitate the mentee's personal and professional growth. Mentors typically share their expertise, wisdom, and experiences to help mentees navigate their career or personal development paths.

Factors influencing the decision to become a supervisor: A qualitative study of early-career general practitioners and rural generalists.

Background And Objectives: General practitioner (GP) training in Australia relies on accredited GP supervisors facilitating workplace-based training for GP registrars. There is a shortage of supervisors that is likely to worsen. This research aimed to elucidate the perspectives of early-career GPs and rural generalists (RGs) about the barriers, motivators and enablers to becoming a GP supervisor.

Factors affecting the specialty choice among medical students of Saudi Arabia; an exploratory study.

Background: Career or specialty choice is one of the crucial steps of a medical student's life. It's a difficult yet important decision that is hard to reverse after getting into the residency program. The recent catastrophic experience of shortage and maldistribution of the health workforce among different specialties during the recent pandemic has made it critical for the authorities to look into the motivators and determinants for the specialty choice from the undergraduate medical student's perspective.

The Effect of Epidural Analgesia on In-Hospital Outcomes in Patients with Acute Pancreatitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Objectives: Acute pancreatitis (AP) can lead to severe complications and high mortality. Previous studies suggest that epidural analgesia (EA) may reduce AP severity and improve outcomes. This systematic review and meta-analysis aimed to evaluate the efficacy of EA on in-hospital outcomes in AP patients.

Efficacy of submucosal administration of tramadol on acute pain following third molar surgery: a systematic review and meta-analysis.

Objectives: This systematic review aimed to assess the effectiveness of submucosal tramadol injections in post-operative pain management following third molar surgical extraction.

Materials And Methods: Databases, such as PubMed, Scopus, ScienceDirect, and Cochrane Library, were systematically searched using relevant keywords. Randomized clinical trials that met the inclusion criteria were assessed to determine the effectiveness of tramadol in managing acute post-operative pain following third molar surgery.

VALIDITY OF LELLI'S TEST IN DIAGNOSING ACUTE ACL INJURY AND ITS COMPARISON WITH THE OTHER CONVENTIONAL CLINICAL EXAMS.

Background: The anterior cruciate ligament (ACL) is a vital structure in the knee responsible for preventing anterior translation; and countering rotational and valgus stress. The anteromedial and posterolateral bundles of the ACL, which are distinguished by their attachments at the tibia and femur, respectively, make up the ACL. The study is designed to evaluate the diagnostic parameters of lever sign in acute settings when compared against MRI as investigation of choice and compare them with the conventional tests.

Efficacy and Safety of LigaSure in Breast Surgery With Axillary Lymph Node Dissection in Patients With Breast Cancer: A Systematic Review and Meta-Analysis.

Background: Conventional axillary lymph node dissection (ALND) is associated with significant post-operative morbidity in patients undergoing breast surgery due to increased lymphatic leakage. LigaSure, an electrothermal bipolar vessel sealing system, provides better closure of the leakage. This study aims to compare the efficacy and safety of LigaSure against conventional techniques in patients with breast cancer underwent ALND and breast surgery.