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Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation: Optimizing 5-Fluorouracil Dosing in Children With Pediatric Ependymoma.

CPT Pharmacometrics Syst Pharmacol

April 2016

Department of Pharmaceutical Sciences St. Jude Children's Research Hospital Memphis Tennessee USA.

V M Daryani Y T Patel M Tagen D C Turner A M Carcaboso

We previously investigated novel therapies for pediatric ependymoma and found 5-fluorouracil (5-FU) i.v. bolus increased survival in a representative mouse model.

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Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation: Optimizing 5-Fluorouracil Dosing in Children With Pediatric Ependymoma.