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Expression of the ErbB family of receptors in ovarian cancer.

J Soc Gynecol Investig

August 1998

Department of Obstetrics and Gynecology, University of Illinois at Chicago, College of Medicine 60621, USA.

Objective: To characterize the relative levels of the ErbB family of receptors and their relationship to one another in ovarian cancer.

Methods: A total of 17 serous cystadenocarcinomas were analyzed for epidermal growth factor receptor (EGF-R or ErbB-1) and ErbB-2, ErbB-3, and ErbB-4 receptor expression by Western blot analysis. Receptor levels were quantified by densitometry and expressed as relative densitometry units normalized to the level of alpha-tubulin.

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