Deletion of pagL and arnT genes involved in LPS structure and charge modulation in the Salmonella genome confer reduced endotoxicity and retained efficient protection against wild-type Salmonella Gallinarum challenge in chicken.

Fowl typhoid (FT) poses a significant threat to the poultry industry and can cause substantial economic losses, especially in developing regions. Caused by Salmonella Gallinarum (SG), vaccination can prevent FT. However, existing vaccines, like the SG9R strain, have limitations, including residual virulence and potential reversion of pathogenicity.

Exploring the potential of machine learning models to predict nasal measurements through facial landmarks.

Statement Of Problem: Information on predicting the measurements of the nose from selected facial landmarks to assist in maxillofacial prosthodontics is lacking.

Purpose: The objective of this study was to identify the efficiency of machine learning models in predicting the length and width of the nose from selected facial landmarks.

Material And Methods: Two-dimensional frontal and lateral photographs were made of 100 men and 100 women.

Sources of HIV information and women's HIV knowledge in Southwest Sumba Indonesia: a cross-sectional study with mediation analysis.

Background: Despite multiple years of government HIV educational efforts, the growing trend of new cases among women in Indonesia runs parallel with their seemingly overall lack of comprehensive knowledge about HIV. A major prevention challenge for the Indonesian government lies in delivering HIV prevention education across the world's largest archipelago. This study investigates comprehensive HIV knowledge among reproductive-age women in Southwest Sumba, Indonesia, and the sources through which they report having learned about HIV along with potential mediators of the relationship between socioeconomic status (SES) and HIV knowledge.

Development of a standardized patient-reported clinical questionnaire for children with spinal pain.

Background: Spinal pain affects up to 30% of school-age children and can interfere with various aspects of daily life, such as school attendance, physical function, and social life. Current assessment tools often rely on parental reporting which limits our understanding of how each child is affected by their pain. This study aimed to address this gap by developing MySpineData-Kids ("MiRD-Kids"), a tailored patient-reported questionnaire focusing on children with spinal pain in secondary care (Danish hospital setting).

Efficacy and safety of PD-1 blockade-activated neoantigen specific cellular therapy for advanced relapsed non-small cell lung cancer.

Background: Due to its strong immunogenicity and tumor specificity, neoplastic antigen has emerged as an immunotherapy target with wide therapeutic prospect and clinical application value. Anti-programmed death-1 (PD-1) antibodies reinvigorate T cell-mediated antitumor immunity. So, we conducted single-arm trial to assess the safety and efficacy of PD-1 blockade(Camrelizumab)-activated neoantigen specific cellular therapy (aNASCT) on advanced relapsed non-small lung cancer(NSCLC)(ClinicalTrials.

Neural Voices of Patients with Severe Brain Injury?

Studies have shown that some covertly conscious brain-injured patients, who are behaviorally unresponsive, can reply to simple questions via neuronal responses. Given the possibility of such neuronal responses, Andrew Peterson et al. have argued that there is warrant for some covertly conscious patients being included in low-stakes medical decisions using neuronal responses, which could protect and enhance their autonomy.

Intramolecular Repulsive Interactions Enable High Efficiency of NIR-II Aggregation-Induced Emission Luminogens for High-Contrast Glioblastoma Imaging.

Strategies to acquire high-efficiency luminogens that emit in the second near-infrared (NIR-II, 1000-1700 nm) range are still rare due to the impediment of the energy gap law. Herein, a feasible strategy is pioneered by installing large-volume encumbrances in a confined space to intensify the repulsive interactions arising from overlapping electron densities. The experimental results, including smaller coordinate displacement, reduced reorganization energy, and suppressed internal conversion, demonstrate that the repulsive interactions assist in the inhibition of radiationless deactivation.

Comparative Analysis of Dental Age Estimation: A Systematic Review and Meta-analysis Assessing Gender-Specific Accuracy of the Demirjian and Nolla Methods Across Different Age Groups.

Chronological age (CA) estimation is essential in medicine, forensics, and law. Teeth are often used for this due to their reliability. The Demirjian and the Nolla methods are used to estimate dental age (DA).

Interprofessional Education for Domestic Violence Safety Planning in Nursing and Social Work: A Scoping Review.

Rationale: Nurses and social workers in healthcare settings are positioned to identify abuse and contribute to improving the wellbeing of victims and their family members by screening for, providing safety education about, and reporting abuse when required by law.

Objective: The review aims to assess the current state of the simulation education for addressing the needs of domestic violence (DV) survivors to screen, assess, and intervene in DV cases in healthcare settings.

Method: A scoping review to map the peer-reviewed evidence on interprofessional education (IPE) was conducted by means of automated database search for nursing and social work students.

Critical depth prediction based on in-situ stress and gas content model of deep coalbed methane in Liupanshui Coalfield in China.

In-situ stress plays a pivotal role in influencing the desorption, adsorption, and transportation of coalbed methane. The reservoir gas content represents a pivotal physical parameter, encapsulating both the coalbed methane enrichment capacity and the underlying enrichment law of the reservoir. This investigation collates, computes, and consolidates data concerning pore pressure, breakdown pressure, closure pressure, triaxial principal stress, gas content, lateral pressure coefficient, and other pertinent variables from coal reservoirs within several coal-bearing synclines in the Liupanshui coalfield, China.

Hydrological dynamics of the Yangtze river-Dongting lake system after the construction of the three Gorges dam.

The Yangtze River-Dongting Lake link has gotten a lot of attention as a because of the Three Gorges Project. However, the hydrological dynamic process and future direction of the river-lake interaction in the context of sediment reduction are yet unknown. Based on Dongting Lake Basin runoff and sediment data from 1961 to 2020, as well as field monitoring data of turbidity and flow velocity from Yichang to Chenglingji section of the Yangtze River, this paper examines the runoff and sediment variation law and hydrological dynamic process of Chenglingji, the only outlet connecting Dongting Lake to the Yangtze River, and reveals the development trend of the river-lake relationship.

Health needs of older people and age-inclusive health care in humanitarian emergencies in low-income and middle-income countries: a systematic review.

Health needs of older people in humanitarian settings are poorly documented, negatively affecting the appropriateness of health services they receive. This Review identified the major health needs of older people across humanitarian contexts, including non-communicable diseases and mental health conditions (eg, psychological distress and depression). Barriers to health care of older people included inaccessibility of health-care services; shortage of appropriate health care; insufficient availability of medications and medical equipment; poor geriatric expertise of health-care staff, health policy makers, and health authorities; and age discrimination by health-care personnel.

Obstacles to implementing indigenous knowledge in climate change adaptation in Africa.

In a climate change context, indigenous and local knowledge includes the use of traditional practices, crop varieties, and land management techniques that have evolved in response to local climatic conditions. This inter-generational transfer of knowledge is crucial for maintaining and adapting these practices to meet the challenges posed by climate change. Despite the many advantages of using indigenous knowledge in climate change adaptation in Africa, its implementation faces several obstacles.

Cognitive and preference disparities of Chinese consumers regarding the disclosure of unsafe food recall information.

Introduction: Information disclosure is important in promoting unsafe food recalls and reducing potential food safety risks. However, the governance of unsafe food recall information in China is distorted, leading to cognitive dissonance in Chinese consumers' perceptions of unsafe food recall information. Focusing on consumers' search and cognitive costs, this study suggests that market regulators should proactively and fully disclose unsafe food recall information to satisfy consumers' needs and preferences for recall information, thereby optimizing consumer perceptions and facilitating the improvement of the information governance system for unsafe food recalls.

Community case study: Our Wave, an online platform to facilitate survivor disclosure of sexual assault and trauma recovery.

This community case study introduces Our Wave, an online platform that provides a safe, anonymous space for survivors of sexual harm to share their stories, reflect on their healing journeys, and connect with others. Designed to empower survivors, the platform allows users to post anonymous stories or visual media, ask questions, and send messages of hope, all while prioritizing privacy and security. It also aims to create a broader impact by analyzing shared narratives to detect patterns, identify best practices for healing, and inform global approaches to SV recovery.

Winter-spring droughts exacerbated PM-O compound pollution? Evidence from China.

With the impact of global climate change, drought events are becoming more frequent, making it critically important to quantitatively evaluate the effects of these events on air pollution. This study uses the augmented synthetic control method and the mediation effect model to quantitatively evaluate the impact effect of the winter-spring drought of 2023 on PM-O compound pollution and its driving factors with Chinese prefecture-level city data. This study indicates that: firstly, compared to non-drought periods, both the monthly averaged and diurnal variations pattern of PM and O significantly increased during drought periods.

From Choice to Justice: Disrupting the Binary Political Logics of Assisted Reproduction.

Reproductive rights and reproductive justice paradigms have long been viewed as incompatible, largely because of their divergent orientations to the notion of choice. According to this oppositional framing, reproductive rights approaches have centered the right of (white, middle-class, heterosexual) women to choose not to have children while reproductive justice organizing has focused on gendered, racialized, and classed obstacles to control over whether and how to have and raise children. Amid increasing examination of assisted reproductive technologies (ARTs) vis-à-vis human rights principles, I see an opportunity to narrow the perceived gap between the politics of rights and justice.

Securing the Right to Health of Asylum Seekers: A Small-Scale Qualitative Case Study in Thessaloniki, Greece.

Deploying legal analysis and a small-scale qualitative dataset, this paper considers the right to health of asylum seekers, as a subgroup of distress migrants, in Greece in the years preceding the COVID-19 pandemic and thereafter. The public health care system in Greece is operating under significant constraints stemming from austerity policies. We analyze the legal entitlements of asylum seekers as found in Greek and international law and confirm a significant gap between the right to health in theory and the right to health in practice.

Assessing law enforcement officer skills in Crisis Intervention Team (CIT) research: developing and implementing standardized scenarios.

This paper outlines the development of standardized scenarios used to assess the efficacy of Crisis Intervention Team (CIT) training in a randomized, controlled trial. The objective was to create scenarios that accurately simulate mental health crisis situations for law enforcement officers, ensuring that each scenario tests specific CIT skills relevant to real-world encounters. Our process involved building an interdisciplinary team and drawing from the knowledge and experience of professionals in law enforcement, mental health, and performance arts to design a set of scenarios that are both realistic and challenging.

Assisted dying legislation: challenges and considerations for community nurses.

The article focuses on assisted dying, its legislation process and why it might be a political priority for UK lawmakers at this time. The author also raises questions about what the implications of this bill for nurses, particularly community nurses. The article mentions places outside the UK where assisted dying is already a feature of healthcare.

Impact of medical and recreational cannabis laws on inpatient visits for asthma.

Objective: To examine the impact of medical and recreational cannabis laws on inpatient visits for asthma and by payer-type.

Study Setting And Design: Quasi-experimental difference-in-differences regression analysis was conducted while accounting for variations in cannabis laws implementation timing by states. Inpatient visits for asthma in states with a given type of cannabis law were compared with those in states that did not implement the specific law.