Preventative Cancer Vaccine-Elicited Human Anti-MUC1 Antibodies Have Multiple Effector Functions.

Background/objectives: Mucin-1 (MUC1) is a transmembrane glycoprotein that is overexpressed and hypoglycosylated in premalignant and malignant epithelial cells compared to normal cells, creating a target antigen for humoral and cellular immunity. Healthy individuals with a history of advanced colonic adenomas and at high risk for colon cancer were enrolled in a clinical trial to evaluate the feasibility of using a MUC1 peptide vaccine to prevent colon cancer. Anti-MUC1 antibodies elicited by this vaccine were cloned using peripheral blood B cells and sera collected two weeks after a one-year booster.

Understanding of Key Considerations for Effective Community Engagement in Genetics and Genomics Research: A Qualitative Study of the Perspectives of Research Ethics Committee Members and National Research Regulators in a low Resource Setting.

To attain effective community engagement (CE) for genetics and genomics research (GGR) is a challenge. This study aimed to analyzed participants' perspectives on how to attain effective CE for GGR in Uganda. A cross-sectional qualitative study involving in-depth interviews with twenty research ethics committee members and three national research regulators was conducted.

Loneliness, Discrimination, Stress, and Type 2 Diabetes Risk in Young Adults.

Introduction: The aim of this study was to determine the associations between type 2 diabetes or prediabetes and loneliness and related social experiences in young adults, a population at increasingly high risk of type 2 diabetes.

Methods: This was a cross-sectional analysis using data from adults aged 18-35 years enrolled in the All of Us Research Program. Exposures included loneliness, social support, discrimination, neighborhood social cohesion, and stress, measured by standardized surveys.

Effect of Heart Rate Variability Biofeedback on Cardiac Autonomic Activation and Diabetes Self-Care in Patients with Type II Diabetes Mellitus.

In type 2 diabetes mellitus (T2DM), decreased autonomic activation and heightened negative emotions may worsen glycemic control. This study investigated the effects of heart rate variability biofeedback (HRVB) on autonomic activation, negative emotions, diabetes self-care, and glycemic control in patients with T2DM. A total of 61 participants with T2DM were assigned to either the HRVB group (n = 30; 62.

Household health expenditure does not improve people's subjective well-being in China.

Introduction: Household health expenditure plays a crucial role in the daily spending of individuals. Meanwhile, the attention of the public to subjective well-being (SWB) is constantly increasing in China. Household health expenditure could reduce real family income, harming personal SWB.

Harnessing AI and analytics to enhance cybersecurity and privacy for collective intelligence systems.

Collective intelligence systems like Chat Generative Pre-Trained Transformer (ChatGPT) have emerged. They have brought both promise and peril to cybersecurity and privacy protection. This study introduces novel approaches to harness the power of artificial intelligence (AI) and big data analytics to enhance security and privacy in this new era.

Leveraging machine learning algorithms in dynamic modeling of urban expansion, surface heat islands, and carbon storage for sustainable environmental management in coastal ecosystems.

Climate change and rapid urbanization are dramatically altering coastal ecosystems worldwide, with significant implications for land surface temperatures (LST) and carbon stock concentration (CSC). This study investigates the impacts of day and night time LST dynamics on CSC in Cox's Bazar, Bangladesh, from 1996 to 2021, with future projections to 2041. Using Landsat and MODIS imagery, we found that mean daytime LST increased by 3.

Human perceptions of social robot deception behaviors: an exploratory analysis.

Introduction: Robots are being introduced into increasingly social environments. As these robots become more ingrained in social spaces, they will have to abide by the social norms that guide human interactions. At times, however, robots will violate norms and perhaps even deceive their human interaction partners.

Dyadic and Longitudinal Influences of Sexual Communication on Relationship Satisfaction, Emotional Intimacy, and Daily Affect Among Same-Sex Male Couples.

The influences of sexual communication on relational outcomes have garnered attention in the current literature, but such dynamics have seldom been explored among same-sex couples using dyadic, longitudinal data. The current study investigates the actor (i.e.

Decision support system based on bipolar complex fuzzy Hamy mean operators.

The important feature of the multi-attribute decision-making (MADM) technique is to identify an ideal solution and aggregate collective cognitive fuzzy information of human opinion. To serve this purpose, we explore the concepts of the bipolar complex fuzzy set with positive and negative support terms. A few applications of the Hamy mean (HM) and Dual Hamy mean (DHM) models are also discussed to find out the relationship among input arguments or different preferences.

Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson's disease models.

Background: The burgeoning field of regenerative medicine has significantly advanced with recent findings on biotherapies using human platelet lysates (HPLs), derived from clinical-grade platelet concentrates (PCs), for treating brain disorders. These developments have opened new translational research avenues to explore the neuroprotective effects of platelet-extracellular vesicles (PEVs). Their potential in managing neurodegenerative conditions like traumatic brain injury (TBI) and Parkinson's disease (PD) warrants further exploration.

Explainable machine learning framework to predict the risk of work-related neck and shoulder musculoskeletal disorders among healthcare professionals.

Objective: This study aims to develop risk prediction models for neck and shoulder musculoskeletal disorders among healthcare professionals.

Methods: A stratified sampling method was employed to select employees from medical institutions in Nanning City, yielding 617 samples. The Boruta algorithm was used for feature selection, and various models, including Tree-Based Models, Single Hidden-Layer Neural Network Models (MLP), Elastic Net Models (ENet), and Support Vector Machines (SVM), were applied to predict the selected variables, utilizing SHAP algorithms for individual-level local explanations.

Long-acting injectable antiretroviral treatment: experiences of people with HIV and their healthcare providers in Uganda.

Introduction: Long-acting injectable antiretroviral treatment (LAI-ART) has emerged as a novel alternative to the burden of daily oral pills. The bi-monthly intramuscular injectable containing cabotegravir and rilpivirine holds the promise of improving adherence to ART. The perspectives of potential users of LAI-ART, the majority of whom reside in Eastern and Southern Africa, are still largely unexplored.

Seroprevalence and molecular detection of infection in livestock in the United Arab Emirates.

Small ruminants and camels are important livestock species in the United Arab Emirates (UAE), although infection can limit their productivity. This study aimed to investigate the seroprevalence of infection and its associated risk factors in small ruminants and camels in the Emirate of Abu Dhabi. Additionally, seropositive animals were tested for the DNA of .

Does stress from incarceration of family and friends contribute to signs of early vascular ageing in African American women?

Background: Early vascular ageing (EVA) contributes to elevated risk of cardiovascular disease (CVD), which disproportionately affects African American women. Incarceration, an event disproportionately impacting African Americans, may be a stressor contributing to EVA in African American women. Further, the subjective perspective, commonly referred to as appraisal, of incarceration may also be important for health.

Understanding brucellosis: knowledge, perceptions, and self-reported prevalence among agro-pastoralists in Nakasongola, Uganda.

Background: Brucellosis is an infectious zoonotic disease that poses serious health threats around the world including Uganda. Brucellosis is caused by Brucella spp., the bacteria being transmitted via contact through skin breaks, via inhalation, or orally through the consumption of raw milk and other dairy products.

Interventions for adolescent mental, sexual and reproductive health in West Africa: A scoping review.

Objectives: A quarter of West Africa's population are adolescents 10-19 years. Their mental, sexual, and reproductive health is inter-related. We therefore aimed to examine published evidence on effectiveness of interventions for adolescent mental, sexual and reproductive health in the Economic Community of West African States (ECOWAS) to inform development, implementation and de-implementation of policies and programs.