Mapping organism-wide single cell mRNA expression linked to extracellular vesicle biogenesis, secretion and cargo.

Extracellular vesicles (EVs) are functional lipid-bound nanoparticles trafficked between cells and found in every biofluid. It is widely claimed that EVs can be secreted by every cell, but the quantity and composition of these EVs can differ greatly among cell types and tissues. Defining this heterogeneity has broad implications for EV-based communication in health and disease.

Mapping the Drivers of Multisectoral Nutrition Governance and Its Link to Nutrition Outcomes in Kenya: A Qualitative Inquiry.

Background: Malnutrition remains a significant public health issue in Kenya. Multisectoral Nutrition Governance (MNG) is increasingly being acknowledged as a catalyst for enhancing nutrition programming and outcomes. Effective MNG establishes policies, systems, and mechanisms that enable coordinated, adequately funded, and sustainable nutrition actions across sectors; however, its understanding and progress assessment remain inadequate.

Sex-specific activation of platelet purinergic signaling is key in local cytokine release and phagocytosis in the peritoneal cavity in intra-abdominal sepsis.

Intra-abdominal sepsis is a life-threatening complex syndrome caused by microbes in the gut microbiota invading the peritoneal cavity. It is one of the major complications of intra-abdominal surgery. To date, only supportive therapies are available.

Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance.

Microbial species must compete for space and nutrients to persist in the gastrointestinal (GI) tract, and our understanding of the complex pathobiont-microbiota interactions is far from complete. Klebsiella pneumoniae, a problematic, often drug-resistant nosocomial pathogen, can colonize the GI tract asymptomatically, serving as an infection reservoir. To provide insight on how K.

Associations between Driving Cessation and Mental Health among Rural and Urban Older Adults.

Driving cessation is robustly associated with poor mental health outcomes among older adults; however, the magnitude of this relationship may differ by rurality. This study examined cross-sectional and longitudinal associations between driving cessation and life satisfaction and depressive symptoms and assessed whether these relationships were moderated by rurality. Data is from participants in the 2014 and 2016 Health and Retirement Study (HRS) (mean age = 73; 58% female) with information on either depressive symptoms (n=5,650) or life satisfaction (n=1,931).

Physical activity and quality of life among breast cancer survivors: Pink SWAN.

Purpose: To describe physical activity (PA) trajectories across 10 years post-breast cancer diagnosis and examine their association with quality of life (QoL).

Methods: Participants from the longitudinal Study of Women's Health Across the Nation who developed incident breast cancer completed the Quality of Life in Adult Cancer Survivors scale (QLACS) which has 12 domains. Breast cancer survivors (BCS) with at least one post-diagnosis measure of the Kaiser Physical Activity Survey (PA) were included (n = 96).

One size does not fit all: the multifaceted impact of COVID-19 on graduate-level behavioral health professions students.

Better understanding how behavioral health professions students were impacted by COVID-19 can help educators inform their education practices. The present study examined the impact of COVID-19 among  = 83 students enrolled in two universities across five graduate-level behavioral health training programs - clinical mental health counseling, marriage and family therapy, psychiatric nursing, and social work. Participants completed the Epidemic-Pandemic Impacts Inventory (EPII), and descriptive statistics were examined.

Fostering Collaborative Practice Through Interprofessional Education.

Background And Objectives: Health care leaders use interprofessional collaborative practice as a strategy to improve health outcomes, and they have stressed its importance in the education of primary care medical providers to apply public health concepts like the social determinants of health and community collaborations. Interprofessional education (IPE) prepares students from different professions for collaborative practice as they enter the health workforce by developing core competencies. Understanding the importance of IPE is vital toward improving person and client-centered care and population health outcomes.

Causal Mediation Analysis of Foodborne Outbreaks in the United States: Serotypes and Food Vehicles.

Various serotypes have caused numerous foodborne outbreaks associated with food vehicles in different categories. This study provides evidence on the occurrence and inter-relations between serotypes and the number of deaths mediated by the number of illnesses and hospitalizations. Confirmed foodborne outbreaks of serotypes (n = 2868) that occurred between 1998 and 2021 were obtained from the Centers for Disease Control and Prevention National Outbreak Reporting System.

Healthcare Access and County-Level COVID-19 Mortality: Exploring the Impact of Hospital Proximity and Uninsurance Rates.

Background/objectives: Many social and environmental factors contribute to the disproportionate burden of COVID-19 mortality. Access to healthcare services has not been thoroughly examined as a factor contributing to COVID-19 mortality. This study examines distance to ERs and ICUs, uninsurance rates, and county-level COVID-19 mortality rates.

Insights for the Next Generation of Ketamine for the Treatment of Depressive Disorder.

Treatment-resistant depression responds quickly to ketamine. As an -methyl-d-aspartate receptor (NMDAR) antagonist, ketamine may affect prefrontal cortex (PFC) neurons. Recent investigations reveal that the ()-enantiomer is the most effective and least abuseable antidepressant.

Simultaneous removal of heavy metals and inorganic nitrogen by using the biofilm of Marichromatium gracile YL28.

Heavy metal and nitrogen contaminations are serious concerns in aquatic environments. Marichromatium gracile YL28, a marine purple sulfur bacterium, has shown great potential as a bioremediation agent for removing inorganic nitrogen from marine water. This study further investigated its ability to simultaneously absorb heavy metals, including Pb(II), Cu(II), Cd(II) and Cr(VI), and remove inorganic nitrogen.

Increasing diversity in the nutrition, obesity, and diabetes biomedical workforce: the BRIDGES consortium.

Scientists from diverse backgrounds are underrepresented (UR) in academia. This lack of diversity impedes scientific discovery and innovation. UR scientists tend to conduct research on issues relevant to UR populations, including chronic disease prevention and management, and health disparities.

You are not fully present with me: How own and perceived partner mindfulness shape relationship outcomes.

The purpose of this study was to examine the intrapersonal and interpersonal associations among mindfulness, perceived partner mindfulness, and relationship outcomes in married couples. Mindfulness is a quality of mind that is likely to translate into observable behaviors; thus, individuals may perceive their spouse's tendency to be mindful. Despite this, the link between perceived partner mindfulness and marital outcomes has not yet been explored.

Synthesis and Characterization of Transferrin and Cell-Penetrating Peptide-Functionalized Liposomal Nanoparticles to Deliver Plasmid ApoE2 and in Mice.

Alzheimer's disease (AD) is a prevalent neurodegenerative condition characterized by the aggregation of amyloid-β plaques and neurofibrillary tangles in the brain, leading to synaptic dysfunction and neuronal degeneration. Recently, new treatment approaches involving drugs such as donanemab and lecanemab have been introduced for AD. However, these drug regimens have been associated with adverse effects, leading to the exploration of gene therapy as a potential treatment option.

Involving youth with intellectual and/or developmental disabilities as collaborators in a comparative effectiveness trial: A community-engaged research approach.

Background: Practices to include youth with intellectual and/or developmental disabilities (IDD) are necessary to design and implement research that specifically meets the behavioral health needs of this population. This article describes a protocol for engaging youth with IDD as collaborators in a comparative effectiveness clinical trial using a community-engaged research (CEnR) approach.

Methods: Our engagement protocol, guided by the Community Engaged Research (CEnR) Framework, emphasized harm avoidance, accessibility, demonstrated value, capacity bridging and co-learning, shared power and equity in decision-making, accountability and respect, and transparent communication.

Gaps and opportunities for measuring equity with the Translational Science Benefits Model: Recommendations from the Center for American Indian and Alaska Native Diabetes Translation Research.

Translational research needs to show value through impact on measures that matter to the public, including health and societal benefits. To this end, the Translational Science Benefits Model (TSBM) identified four categories of impact: Clinical, Community, Economic, and Policy. However, TSBM offers limited guidance on how these areas of impact relate to equity.

Temporal trends in online searches related to COVID-19 vaccine safety: A digital infodemiology study.

Background: The rapid development of COVID-19 vaccines may have raised public concerns about their safety and side effects in the United States (US). This study aimed to assess trends in online searches related to the safety and side effects of COVID-19 vaccines in the US from 2021-2022.

Methods: Google COVID-19 Vaccination Search Insights was used to analyze searches about COVID-19 vaccine safety and side effects in the US from January 4, 2021, to November 21, 2022 (98 weeks).

Associations Between Dietary Patterns and Quality of Life in a Longitudinal Cohort of Colorectal Cancer Survivors.

Purpose: To characterize dietary patterns and examine associations with cross-sectional and longitudinal changes in quality of life (QOL) over approximately one year after colorectal cancer (CRC) diagnosis.

Methods: The ColoCare Study is an international, multi-center, prospective cohort study of newly diagnosed CRC survivors of any stage. A subset of participants with CRC in the United States completed patient-reported outcome measures at 6- and 12-months post-enrollment, including the Food Frequency Questionnaire (FFQ) and European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30).

Physical Activity Outcomes of a Culturally Tailored, Father-Focused, and Family-Centered Health Promotion Program for Mexican-Heritage Families: (Make Room for Daddy).

Despite the health benefits of physical activity (PA), many individuals do not meet PA recommendations. Family-centered PA approaches, particularly active engagement by Mexican-heritage fathers, may support family PA. This study reports PA outcomes of a culturally tailored, father-focused, and family-centered, program for Mexican-heritage families.