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Human Infant Fecal Microbiota Differentially Influences the Mucosal Immune Pathways Upon Influenza Infection in a Humanized Gnotobiotic Pig Model.
Curr Microbiol
July 2024
Department of Animal Sciences, Center for Food Animal Health (CFAH), College of Food Agricultural and Environmental Sciences (CFAES), 1680 Madison Avenue, Wooster, OH, 44691, USA.
Article Synopsis
- This study explored how different gut microbiota from rural and urban infants affect immune responses in the respiratory tract of gnotobiotic piglets infected with H1N1 influenza virus.
- Piglets with urban infant fecal microbiota showed higher viral loads in the upper respiratory tract, while both groups had similar virus-specific antibody responses, indicating a complex interaction between gut bacteria and immune response.
- The research highlighted distinct immune regulation patterns and changes in gut microbiota following influenza infection in piglets, suggesting that different microbiota can influence respiratory health and may help in developing new therapies.