2 results match your criteria: "College of Biotechnology Tianjin University of Science and Technology[Affiliation]"
Tumor vasculature-targeting PEGylated peptide-drug conjugate prodrug nanoparticles improve chemotherapy and prevent tumor metastasis.
Eur J Med Chem
July 2021
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology Tianjin University of Science and Technology, No.29 of 13 th Avenue, TEDA, Tianjin, 300457, PR China. Electronic address:
Metastasis is the main cause of death in cancer patients; therefore, new strategies or technologies that can inhibit the growth of primary tumors and their metastatic spread are extremely valuable. In this study, we selected an E-selectin-binding peptide as a targeting ligand and an inhibitor of metastasis, and conjugated this peptide with SN38 and PEG to produce an amphiphilic PEGylated peptide-drug conjugate (PDC). Novel self-assembled nanoparticles were then formed by the amphiphilic conjugate.
View Article and Find Full Text PDFReducing lactate secretion by ldhA Deletion in L-glutamate- producing strain Corynebacterium glutamicum GDK-9.
Braz J Microbiol
October 2015
College of Biotechnology Tianjin University of Science and Technology Tianjin P.R. China College of Biotechnology, Tianjin University of Science and Technology, Tianjin, P.R. China. ; Key Laboratory of Industrial Microbiology Education Ministry Tianjin P.R. China Key Laboratory of Industrial Microbiology, Education Ministry, Tianjin, P.R. China.
L-lactate is one of main byproducts excreted in to the fermentation medium. To improve L-glutamate production and reduce L-lactate accumulation, L-lactate dehydrogenase-encoding gene ldhA was knocked out from L-glutamate producing strain Corynebacterium glutamicum GDK-9, designated GDK-9ΔldhA. GDK-9ΔldhA produced approximately 10.
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