5 results match your criteria: "College of Basic Medical Sciences Jilin University Changchun China.[Affiliation]"
Purpose: Understanding the molecular mechanisms of adaptive regulation in the tumor microenvironment is crucial for precision therapy in hepatocellular carcinoma (HCC). We hypothesized that cargo proteins carried by extracellular vesicles (EVs) released in a hypoxic microenvironment might promote HCC progression by remodeling tumor-associated macrophages (TAMs).
Methods: EV protein analysis by label-free proteomics mass spectrometry of HCC cell lines of different tumor grades was performed.
A novel in-frame deletion in KIF5C gene causes infantile onset epilepsy and psychomotor retardation.
MedComm (2020)
April 2024
Department of Human Genetics and Department of Ultrasound, Women's Hospital School of Basic Medical Science Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorders Zhejiang University School of Medicine Hangzhou China.
Article Synopsis
- Motor proteins from the Kinesin superfamily are vital for brain development and have been linked to neurodevelopmental disorders.
- A case involving a 6-year-old boy with severe epilepsy and intellectual disabilities revealed a novel genetic deletion in the KIF5C gene that affects crucial protein function.
- The study highlights how this genetic variant disrupts normal cellular processes and reinforces the need for further understanding of KIF5C's role in neurodevelopment to improve diagnosis and treatment options.
Cardiovascular disease (CVD) significantly impacts global society since it is the leading cause of death and disability worldwide, and extracellular vesicle (EV)-based therapies have been extensively investigated. EV delivery is involved in mediating the progression of CVDs and has great potential to be biomarker and therapeutic molecular carrier. Besides, EVs from stem cells and cardiac cells can effectively protect the heart from various pathologic conditions, and then serve as an alternative treatment for CVDs.
View Article and Find Full Text PDFAlthough there are reports that artificial sweeteners (AS) are safe, the relationship between artificial sweeteners and cancer remains controversial. The purpose of the study is to evaluate whether the consumption of artificial sweeteners is associated with the risk of cancers. We conducted a comprehensive search of multiple databases, including MEDLINE, EMBASE, Web of Science, and Cochrane Library.
View Article and Find Full Text PDFVitamin A deficiency execrates Lewis lung carcinoma via induction of type 2 innate lymphoid cells and alternatively activates macrophages.
Food Sci Nutr
April 2019
Department of Immunology, College of Basic Medical Sciences Jilin University Changchun China.
Background: Lung carcinoma is still associated with high rates of morbidity and mortality despite the advances in cancer therapy achieved in last decades. Recent studies showed that immune responses played a crucial role in the developments of cancers including lung cancer. Type 1 immune response could promote classical activated macrophages (CAMs) with antitumor properties.
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