Exploring the neuroprotective benefits of phytochemicals extracted from indigenous edible fruits in Bangladesh.

The increasing incidence of neurodegenerative diseases (NDs) and the constraints of existing treatment methods have spurred a keen interest in investigating alternative therapies. Medicinal plants, renowned for their long-standing use in traditional medicine, offer a hopeful avenue for discovering new neuroprotective agents. This study emphasizes the potential neuroprotective characteristics of edible fruit plants in Bangladesh, specifically focusing on their traditional folk medicine uses for neurological disorders.

Polyphenols as Wnt/β-catenin pathway modulators: A promising strategy in clinical neurodegeneration.

Polyphenols, a diverse group of naturally occurring compounds found in plants, have garnered significant attention for their potential therapeutic properties in treating neurodegenerative diseases (NDs). The Wnt/β-catenin (WβC) signaling pathway, a crucial player in neurogenesis, neuronal survival, and synaptic plasticity, is involved in several cellular mechanisms related to NDs. Dysregulation of this pathway is a hallmark in the development of various NDs.

Boosting skin cancer diagnosis accuracy with ensemble approach.

Skin cancer is common and deadly, hence a correct diagnosis at an early age is essential. Effective therapy depends on precise classification of the several skin cancer forms, each with special traits. Because dermoscopy and other sophisticated imaging methods produce detailed lesion images, early detection has been enhanced.

The Influence of Genetic Polymorphisms in Cytochrome P450 (CYP1A1 and 2D6) Gene on the Susceptibility to Philadelphia Negative Chronic Myeloid Leukemia in Sudanese Patients.

The most frequent type of leukemia in Africa is chronic myeloid leukemia (CML). The genetic background of the rarer Philadelphia chromosome (Ph) Ph-ve (BCR-ABL-ve) subform of CML is largely unknown in African patients. Therefore, in this study, we aimed to investigate the role of CYP1A1 and 2D6 SNPs in the pathogenesis of Ph-ve CML in the Sudanese population.

Virtual screening assisted identification of a phytocompound as potent inhibitor against Candida lusitaniae; an in-silico study.

Candida lusitaniae is one of the fungal species which causes serious health illnesses including peritonitis, vaginitis and fungemia, among others. Several antifungal drugs have been designed to tackle its infections but their efficacy is still questionable due to their associated side effects. Hence, there is a need to design those drugs which possess comparatively higher degree of therapeutic potential.

A hybrid framework for colorectal cancer detection and U-Net segmentation using polynetDWTCADx.

"PolynetDWTCADx" is a sophisticated hybrid model that was developed to identify and distinguish colorectal cancer. In this study, the CKHK-22 dataset, comprising 24 classes, served as the introduction. The proposed method, which combines CNNs, DWTs, and SVMs, enhances the accuracy of feature extraction and classification.

From diagnosis to therapy: The role of LncRNA GAS5 in combatting some cancers affecting women.

Long non-coding RNAs (lncRNAs) are a collection of non-coding RNA molecules that consist of more than 200 nucleotides. In human malignancies, these lncRNAs exhibit abnormal expression patterns and play a significant role in either suppressing or promoting tumor growth. They achieve this by modulating various functions and mechanisms within cancer cells, including proliferation, invasion, metastasis, apoptosis, and resistance to different therapeutic approaches.

A cutting-edge investigation of the multifaceted role of SOX family genes in cancer pathogenesis through the modulation of various signaling pathways.

This detailed study examines the complex role of the SOX family in various tumorigenic contexts, offering insights into how these transcription factors function in cancer. As the study progresses, it explores the specific contributions of each SOX family member. The significant roles of the SOX family in the oncogenic environment are well-recognized, highlighting a range of regulatory mechanisms that influence tumor progression.

The effect of educational programs on parents' knowledge, behavior, and practices regarding aluminum phosphide poisoning and its first-aid measures.

Background: Aluminum phosphide is an excellent insecticide available as a chalky white or brown tablet. Aluminum phosphide is traded in the Egyptian market as tablets under the brand name celphos. To date, no specific antidotes for aluminum phosphide poisoning have been identified.

: Routes of Infection, Antimicrobial Resistance, and Alternative Therapies as a Means to Develop Infection Control.

() is a Gram-negative, spiral-shaped bacterium that colonizes the gastric epithelium and is associated with a range of gastrointestinal disorders, exhibiting a global prevalence of approximately 50%. Despite the availability of treatment options, frequently reemerges and demonstrates increasing antibiotic resistance, which diminishes the efficacy of conventional therapies. Consequently, it is imperative to explore non-antibiotic treatment alternatives to mitigate the inappropriate use of antibiotics.

ADME, Toxicity, Molecular Docking, Molecular Dynamics, Glucokinase activation, DPP-IV, α-amylase, and α-glucosidase Inhibition Assays of Mangiferin and Friedelin for Antidiabetic Potential.

Today the alarming situation of diabetes seeks innovative antidiabetic medications, especially those derived from natural sources, as natural substances are safer than manufactured pharmaceuticals. Therefore, this study investigated the inhibitory properties of mangiferin and friedelin against glucokinase (GK), dipeptidyl peptidase-IV (DPP-IV), α-amylase, and α-glucosidase using computational methods, in vitro enzyme assays, and in-depth ADMET analysis. The study utilized a computer-aided drug design approach to assess the potential therapeutic properties of mangiferin and friedelin as Type 2 diabetes mellitus (T2DM) therapeutic agents.

Radiation Protection in the Orthopedics Department: Insights From a Cross-Sectional Study.

Objective: This study assesses radiation protection practices and knowledge among orthopedic surgeons in Saudi Arabia.

Methods: This cross-sectional study surveyed orthopedic surgeons in Saudi Arabia using an online standardized and pre-tested questionnaire. The data were analyzed using statistical software.

Association of burnout and working environment conditions in respiratory care professionals in Saudi Arabia: a cross-sectional study.

Introduction: Burnout is a pervasive issue in healthcare, and it impacts both the wellbeing of healthcare professionals and the quality of patient care. This study examines factors associated with burnout and working environment among respiratory therapists in Saudi Arabia.

Methods: A structured questionnaire was used to collect data from respiratory therapists.

Innovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy.

Millions of people worldwide suffer from cancer, facing challenges such as treatments affecting healthy cells, suboptimal responses, adverse effects, recurrence risk, drug resistance, and nonspecific targeting. Chemoresistance leads to fatalities, but phytoactives show promise in cancer management despite limitations such as high metabolism, poor absorption, and high dosage requirements. Challenges in the large-scale isolation of phytoactive compounds, solubility, bioavailability, and targeting limit their development.

Examining patient safety protocols amidst the rise of digital health and telemedicine: nurses' perspectives.

Background: Integrating digital health and telemedicine technologies is transforming healthcare delivery. In light of this transition, it is critical to ascertain the efficacy of patient safety protocols and evaluate the awareness of healthcare professionals, particularly nurses, regarding the integration of digital health technologies.

Aim: This study examines the factors influencing the successful adoption of digital health and telemedicine technologies from the nurses' perspective, focusing on ensuring patient safety and enhancing organizational readiness for digital health integration.

siRNA-based therapy for overcoming drug resistance in human solid tumours; molecular and immunological approaches.

RNA interference (RNAi) is a primordial biological process that protects against external intrusion. SiRNA has the potential to selectively silence disease-related genes in a sequence-specific way, thus offering a promising therapeutic approach. The efficacy of siRNA-based therapies in cancer treatment has gained significant recognition due to multiple studies demonstrating its ability to effectively suppress cancer cells' growth and multiplication.

Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress.

Objectives: Hepatotoxicity is a severe outcome of methotrexate (MTX) therapy, limiting its clinical use and contributing to its related morbidity and mortality. This study investigated the hepatoprotective effects of nitazoxanide (NTZ), an antiprotozoal drug, against MTX-induced hepatotoxicity and whether endoplasmic reticulum (ER) stress-modulation underlies the expected beneficial effects of NTZ.

Methods: Thirty-six rats were allocated to six groups, one control group and five MTX groups, where induction of hepatotoxicity was achieved via injecting MTX (20 mg/kg).

Prevalence of Glaucoma and Its Bayesian Risk Estimation Model Using Common Determinants in the Adult Population of Hail Region, Saudi Arabia.

Background/objectives: Glaucoma is a global health concern, with an anticipated rise from 64.5 million cases in 2014 to 112 million by 2040. In Saudi Arabia, it contributes to 5.

Efficacy and Safety of Prehospital Blood Transfusion in Traumatized Patients: A Systematic Review and Meta-Analysis.

Background: Approximately five million individuals have traumatic injuries annually. Implementing prehospital blood-component transfusion (PHBT), encompassing packed red blood cells (p-RBCs), plasma, or platelets, facilitates early hemostatic volume replacement following trauma. The lack of uniform PHBT guidelines persists, relying on diverse parameters and physician experience.

Effects of Massage on Self-regulatory Difficulties, Tactile and Oral Abnormalities, and Parenting Stress in Children with Autism Spectrum Disorder (ASD): A Systematic Review and Meta-analysis.

Background: The Centers for Disease Control and Prevention stated that about 1 in every 44 children between the ages of 4 and 8 years old had been identified with autism spectrum disorder (ASD). Complementary interventions such as massage are crucial for the improvement of the health outcomes of ASD patients, such as abnormal sensory response; Autism Behavior Checklist; parenting stress, self-regulatory difficulties, social, language, and communication abilities; tactile or oral abnormalities; Vineland daily living skills; Vineland socialization; Childhood Autism Rating Scale; Preschool Language Scale 5th Edition (PLS-5) auditory communication; and PLS-5 expressive communication.

Purpose: We aim to systematically investigate the effects of different types of massage on self-regulatory difficulties, tactile and oral abnormalities, and parenting stress in children with ASD.

siRNA-based knockdown of lncRNAs: A new modality to target tumor progression.

This study examines the potential of small interfering RNA (siRNA) as a therapeutic agent for cancer targeting long non-coding RNAs (lncRNAs). The article begins with an analysis of the structure and biogenesis of lncRNA. It explains the diverse functions of lncRNAs in cancer, establishing a foundation for assessing approaches to inhibit these molecules.

Investigating the effects of the ARG258HIS mutation on RAD51C in inherited Fanconi Anemia and cancer disease.

Fanconi anemia is a rare chromosomal instability disorder associated with developmental abnormalities, bone marrow failure, and a heightened susceptibility to leukemia and other cancers. It is an autosomal recessive genetic disorder, necessitating both parents to carry the faulty gene. Diagnostic methods include blood tests, chromosome breakage assessments, and genetic testing.

Designed and synthesized novel tripeptides targeting diabetes and its related pathologies.

In diabetes and its associated pathologies, glycation, α-amylase, and α-glucosidase play crucial roles. This study introduces a novel tripeptide, RWW, designed to target glycation and key enzymes in diabetes management. Using in silico methods, RWW was optimized to interact with the glycation-prone Human serum albumin (HSA) sites, as well as inhibit α-amylase and α-glucosidase.

Perceived Physical Activity Levels and Objective Measures: A Mixed-Methods Study of Residents Aged 65 and Above in Assisted Living Homes in Australia.

Communities face a mounting social, economic and health burden as the global population of older adults continues to grow. Regular physical activity is consistently reported as an effective means of maintaining health and independence in older adults, yet engagement in activity remains low. This study assesses the activity levels of adults aged over 65 years residing in Australian assisted living homes, and extended to examine their perception of their activity and explore possible factors that hinder or promote their engagement in physical activity.

Hospitalisation patterns for respiratory diseases in Australia: an ecological study.

Objectives: The objective of this study is to examine the hospitalisation profile for respiratory diseases in Australia between 1998 and 2019.

Design: An ecological study.

Setting: A population study that involved all private and public hospitalisations for respiratory diseases in Australia from 1998 to 2019.