Clinical diagnostic value of PIMREG on liver cancer cell phenotype and tumorigenic ability in nude mice.

Objectives: In vitro experiments were manipulated to investigate the effect of the (PICALM-interacting mitotic regulator gene) expression level on the malignant phenotype of liver cancer cells and their tumorigenesis ability in nude mice, and bioinformatics were used to analyze the clinical diagnostic and prognostic value in liver cancer.

Methods: After liver cancer-related data were obtained from the TCGA database and GTEx database, the differences in expression in liver cancer and normal liver tissue were compared using bioinformatics, and their correlation with the clinical pathological characteristics of liver cancer and the prognosis value were analyzed. A knockdown and overexpression model of was constructed using Huh7 cells.

Long non-coding RNA CASC15 enhances learning and memory in mice by promoting synaptic plasticity in hippocampal neurons.

Alzheimer's disease (AD) is a debilitating systemic disorder that has a detrimental impact on the overall well-being of individuals. Emerging research suggests that long non-coding RNAs play a role in neural development and function. Nevertheless, the precise relationship between lncRNAs and Alzheimer's disease remains uncertain.

Tumor size impact on TNM staging which define post-operative complications in rectal cancer.

The purpose of this study was to see how accurate tumor size was at predicting T and N stages in rectal malignancies. Tumor sizes of 40 mm and greater than 40 mm were used to assess post-operative challenges in related to T1-T2 and T3-T4 stages, as well as between node N0 and node N1 and N2 patients. A total of 131 patients were treated for colorectal cancer, with 54 patients < 40 mm and 77 patients > 40 mm receiving Da Vinci colorectal surgery.

Traumatic biliary fistula with bile duct disconnection.

A 43-year-old man was admitted to our department for accident. Computed tomography (CT) scan revealed low-density shadows in the hepatogastric and peripancreatic space. The patient still has abdominal pain after the performation of CT-guided abdominal puncture and drainage.

Light controlled self-escape capability of non-cationic carbon nitride-based nanosheets in lysosomes for hepatocellular carcinoma targeting stimulus-responsive gene delivery.

High positive charge-induced toxicity, easy lysosomal degradation of nucleic acid drugs, and poor lesion sites targeting are major problems faced in the development of gene carriers. Herein, we proposed the concept of self-escape non-cationic gene carriers for targeted delivery and treatment of photocontrolled hepatocellular carcinoma (HCC) with sufficient lysosome escape and multiple response capacities. Functional DNA was bound to the surface of biotin-PEG-modified graphitic carbon nitride (Bio-PEG-CN) nanosheets to form non-cationic nanocomplexes Bio-PEG-CN/DNA.

Endoscopic resection of a rare duodenal polypoid mass: duodenal angiolipoma.

A 73-year-old man was hospitalized with upper abdominal pain of 1-month duration. Gastroscopy revealed a pedunculated polypoid mass with smooth surface and slightly yellowish color in the duodenal bulb. A long strip shaped mass with very low density in the duodenal was found in abdominal computed tomography .

Associations between gestational age and childhood sleep: a national retrospective cohort study.

Background: Both sleep quality and quantity are essential for normal brain development throughout childhood; however, the association between preterm birth and sleep problems in preschoolers is not yet clear, and the effects of gestational age across the full range from preterm to post-term have not been examined. Our study investigated the sleep outcomes of children born at very-preterm (<31 weeks), moderate-preterm (32-33 weeks), late-preterm (34-36 weeks), early-term (37-38 weeks), full-term (39-40 weeks), late-term (41 weeks) and post-term (>41 weeks).

Methods: A national retrospective cohort study was conducted with 114,311 children aged 3-5 years old in China.

Total glucosides of paeony inhibits liver fibrosis and inflammatory response associated with cirrhosis via the FLI1/NLRP3 axis.

Background: Total glucosides of paeony (TGP) has a myriad of hepatoprotective activities. However, its role in cirrhosis, a major risk factor for hepatocellular carcinoma, remains largely unexplored. Here, we determined the impact of TGP on liver fibrosis and inflammation in mice modeled by carbon tetrachloride with an aim to explore a possible molecular mechanism.

Food Literacy Evaluation Questionnaire (Chinese version, FLEQ-Ch): a validity and cross-cultural adaptation.

Objective: To conduct a Food Literacy Evaluation Questionnaire Chinese Version (FLEQ-Ch) through a cross-cultural validation of the original questionnaire.

Design: This was an observational, cross-sectional study undertaken in two phases: (1) translation and cross-culture adaptation, and (2) psychometric evaluation.

Sample: A total of 509 residents in Yangzhou City, China were enrolled in this study.

Association of Gestational Age at Birth With Subsequent Suspected Developmental Coordination Disorder in Early Childhood in China.

Importance: It remains unknown whether children born at different degrees of prematurity, early term, and post term might have a higher risk of developmental coordination disorder (DCD) compared with completely full-term children (39-40 gestational weeks).

Objective: To differentiate between suspected DCD in children with different gestational ages based on a national representative sample in China.

Design, Setting, And Participants: A retrospective cohort study was conducted in China from April 1, 2018, to December 31, 2019.

Effects of unilateral and bilateral pedicle screw fixation on symptoms and quality of life of patients with lumbar degenerative diseases.

Objective: This research was designed to probe into the effects of unilateral and bilateral pedicle screw fixation on the VAS scores of low back pain, leg pain, ODI indexes and JOA scores in patients with lumbar degenerative diseases.

Methods: Totally 113 patients with lumbar degenerative diseases admitted in our hospital from February 2016 to December 2018 were collected as the research objects. Among them, 52 received bilateral pedicle screw fixation (BPSF) and 61 were treated by unilateral pedicle screw fixation (UPSF).

Tempol prevents isoprenaline-induced takotsubo syndrome via the reactive oxygen species/mitochondrial/anti-apoptosis /p38 MAPK pathway.

Takotsubo Syndrome (TS) is a kind of acute cardiac syndrome with a complex pathophysiological mechanism that remains to be elucidated. The relationship between TS and reactive oxygen species has received increasing attention over in recent years. Therefore, the relationship between TS and reactive oxygen species was investigated in vivo and in vitro.

Comparison on chemical compositions and antioxidant capacities of the green, oolong, and red tea from blueberry leaves.

Blueberry leaves, by-products of the blueberry industry, could be explored as source of functional foods, such as teas. Three different types of tea, including nonfermented green tea, semifermented oolong tea, and fully fermented red tea from blueberry leaves, were investigated on their chemical compositions and antioxidant capacities here. The contents of individual amino acids in three types varied, while the total amounts retained constant.

Particulate Air Pollution Exposure and Plasma Vitamin D Levels in Pregnant Women: A Longitudinal Cohort Study.

Context: No studies have assessed the association between air pollution exposure and vitamin D status in pregnant women.

Objective: To examine the association between particulate air pollution exposure and circulating 25-hydroxyvitamin [25(OH)D] levels in pregnant women.

Design: A longitudinal cohort study.

Hydroquinone Strongly Alleviates Focal Ischemic Brain Injury via Blockage of Blood-Brain Barrier Disruption in Rats.

Hydroquinone (HQ), a major benzene metabolite, occurs naturally in various plants and is manufactured for commercial use. Although HQ displays various biological effects, its neuroprotective effects following ischemic insults have not been investigated. In this study, we first examined neuroprotective effects of HQ in a rat model of transient focal cerebral ischemia.

Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance.

Background: The development of multidrug resistance (MDR) is a crucial problem of therapy failure in gastric cancer, which results in disease recurrence and metastasis. Plasmacytoma variant translocation 1 (PVT-1), a long non-coding RNA (lncRNA), was previously found to be increased in gastric cancer patients and regulated the chemotherapy sensitivity in pancreatic cancer cells. However, the role of PVT1 in multidrug resistant Gastric cancer remains largely unexplored.

Risk prognosis factors of chronic subdural hematoma evacuated by the novel YL-1 hollow needle aspiration drainage system.

Aim: The novel YL-1 hollow needle aspiration drainage system is an effective minimally invasive treatment in chronic subdural hematoma (CSDH). In order to find the risk prognosis factors of chronic subdural hematoma (CSDH) performed by the novel YL-1 hollow needle aspiration drainage system, a logistic analysis of postoperative results was performed.

Methods: One hundred ninety-four cases of chronic subdural hematoma in a period of 7 years since 2004 were collected.

Expression of multidrug resistance-related proteins p-glycoprotein, glutathione-s-transferases, topoisomerase-II and lung resistance protein in primary gastric cardiac adenocarcinoma.

Background/aims: Multidrug resistance (MDR) is closely correlated to an unfavorable prognosis in various human cancers. However, the clinical significance of the expression of MDR-related proteins p-glycoprotein (PGP), glutathione-s-transferases (GST-pi), topoisomerase-II (Topo-II) and lung resistance protein (LRP) in primary gastric cardiac adenocarcinoma (PGCA) remains unclear. In this study, the total of the four kinds of MDR-related proteins mentioned above were detected by using immunohistochemistry and their clinical significance in chemoresistance were also investigated.

[Isolation and cytological identification of a desynaptic variant in rice].

A sterile variant was found from the population of a japonica rice variety Lunhui 422. Cytological investigation was conducted in meiosis. It is showed that the sterility was caused by desynapsis.

[Studies of the correlations between DNA fingerprints and meat production traits in chickens].

This study revealed correlations between DNA fingerprints (DFPs) and slaughter traits of SR92A male x Xiaoshan female hybrids with EAV (endogenous avian retroviral element) as the probe. In the DFP patterns, the band J with molecular weight of about 4 kilobasepairs correlated significantly with alive weight, dressing weight, semi-eviscerated weight, talon weight, breast muscle weight, head weight and thigh weight. The mean alive weight, dressing weight, semi-eviscerated weight and breast muscle weight are 280 g (28.