2 results match your criteria: "Cohen Children's Medical Center of New York at Northwell Health[Affiliation]"
A Novel Brain Injury Biomarker Correlates with Cyanosis in Infants with Congenital Heart Disease.
Pediatr Cardiol
March 2019
Division of Pediatric Cardiology, Department of Pediatrics, Cohen Children's Medical Center of New York at Northwell Health, New Hyde Park, NY, 11040, USA.
Article Synopsis
- Cyanotic heart lesions are a serious type of congenital heart disease causing low oxygen levels in patients until they receive surgery, leading researchers to examine the link between oxygen desaturation, systemic inflammation, and brain injury in patients under one year old.
- They studied 50 patients, classifying them into cyanotic and acyanotic groups based on oxygen saturation levels, and measured various inflammatory markers and brain injury indicators.
- Results showed that those with cyanotic lesions had higher levels of inflammatory markers and brain injury biomarker correlated with lower oxygen saturation, suggesting that poor pre-operative oxygen levels are related to more complications after surgery, highlighting the need for better treatment strategies in these cases.
Brain injury with systemic inflammation in newborns with congenital heart disease undergoing heart surgery.
Exp Ther Med
July 2017
Division of Pediatric Cardiology, Department of Pediatrics, Cohen Children's Medical Center of New York at Northwell Health, New Hyde Park, NY 11040, USA.
Article Synopsis
- - The study examines how systemic inflammation may impact brain injury in newborns with congenital heart disease undergoing cardiac surgery, focusing on specific proteins in their serum before and after surgery.
- - Researchers analyzed the serum levels of proteins like phosphorylated neurofilament-heavy subunit (pNF-H) and S100B, finding them significantly elevated in newborns compared to healthy cord blood, indicating potential brain injury and inflammation.
- - Findings suggest that inflammation and issues like tissue hypoxia during surgery correlate with increased brain injury markers and prolonged mechanical ventilation, highlighting the risks associated with cardiopulmonary bypass.