Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement.

Purpose: Propofol is commonly used as an intravenous anesthetic in surgical patients. However, its usage is associated with adverse effects. Auxiliary medication can reduce the dose of intravenous anesthetics.

[The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study].

To investigate the effects of transcranial direct current stimulation (tDCS) on the disturbance of brain network dysfunction after sleep deprivation (SD). The experimental design of self-control was used in the study. All 16 subjects received 2 times of 24 h SD with an interval of 3 weeks.

A Novel 7-Days Prolonged Dietary Deprivation Regimen Improves ALT and UA After 3-6 Months Refeeding, Indicating Therapeutic Potential.

The aim of this study was to evaluate a total fasting regimen assisted by a novel prebiotic, Flexible Abrosia (FA), in more than 7 days of continual dietary deprivation (7D-CDD). Our analysis included basic physical examinations, bioelectrical impedance analysis, and clinical lab and ELISA analysis in normal volunteers. Seven healthy subjects with normal body weight participated in 7D-CDD with the assistance of a specially designed probiotic.

Hydrogen extends Caenorhabditis elegans longevity by reducing reactive oxygen species.

At present, a large number of studies have reported that hydrogen has antioxidant functions and prevents oxidative stress damage. However, it is not clear whether hydrogen can prolong longevity based on these effects. Therefore, we studied and explored the antiaging potential of exogenous hydrogen and its ability to extend longevity using Caenorhabditis elegans (C.

Corrigendum: Gender Identification of Human Cortical 3-D Morphology Using Hierarchical Sparsity.

[This corrects the article DOI: 10.3389/fnhum.2019.

The effect of acute glutamate treatment on the functional connectivity and network topology of cortical cultures.

Microelectrode arrays (MEAs) allow the investigation of the pharmacological and toxicological effects of chemicals on cultured neuronal networks. Understanding the functional connections between neurons and the resulting neuronal networks is important for evaluating drugs that affect synaptic transmission. Therefore, we acutely treated a mature cultured neuronal network on MEAs with accumulating amounts of glutamate and recorded their altered electrophysiology.

Decreased Information Replacement of Working Memory After Sleep Deprivation: Evidence From an Event-Related Potential Study.

Working memory (WM) components are altered after total sleep deprivation (TSD), both with respect to information replacement and result judgment. However, the electrophysiological mechanisms of WM alterations following sleep restriction remain largely unknown. To identify such mechanisms, event-related potentials were recorded during the n-back WM task, before and after 36 h sleep deprivation.

Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut flora in female juvenile soccer players from Suzhou, China.

Expending a considerable amount of physical energy inevitably leads to fatigue during both training and competition in football. An increasing number of experimental findings have confirmed the relationship between the generation and clearance of free radicals, fatigue, and exercise injury. Recently, hydrogen was identified as a new selective antioxidant with potential beneficial applications in sports.

Functional connectivity changes in the entorhinal cortex of taxi drivers.

Introduction: As a major interface between the hippocampus and the neocortex, the entorhinal cortex (EC) is widely known to play a pivotal role in spatial memory and navigation. Previous studies have suggested that the EC can be divided into the anterior-lateral (alEC) and the posterior-medial subregions (pmEC), with the former receiving object-related information from the perirhinal cortex and the latter receiving scene-related information from the parahippocampal cortex. However, the functional connectivity maps of the EC subregions in the context of extensive navigation experience remain elusive.

Altered expression of thrombospondin-1/-2 in the cortex and synaptophysin in the hippocampus after middle cerebral artery occlusion and reperfusion.

Blood supply returned to infracted tissue causes tissue damage. Therefore, ischemia/reperfusion (I/R) injuries are usually accompanied by synapse formation, but the exact cause is still unknown. To address this question, we established a middle cerebral artery occlusion (MCAO) rat model with different reperfusion times, and we examined neurological deficit scores and brain infarct size.

Disrupted Interactions Between Arousal and Cortical Awareness Networks in MCS and VS/UWS Patients: Evidence from Resting-state Functional Imaging Connectivity.

Clinical patients in a vegetative state or unresponsive wakefulness syndrome (VS/UWS) demonstrate distinct arousal-awareness dissociation; the neuropathological mechanisms underlying such dissociation remain poorly understood. Here, we systematically examined how functional connectivity from the brainstem areas regulating arousal to the cortical networks supporting internal and external awareness is disrupted in minimally conscious state (MCS) and VS/UWS patients. Resting-state functional imaging was conducted in 23 MCS patients, 31 VS/UWS patients, and 20 age-matched healthy individuals.

Regional entropy of functional imaging signals varies differently in sensory and cognitive systems during propofol-modulated loss and return of behavioral responsiveness.

The level and richness of consciousness depend on information integration in the brain. Altered interregional functional interactions may indicate disrupted information integration during anesthetic-induced unconsciousness. How anesthetics modulate the amount of information in various brain regions has received less attention.

The association between inflammation, the microbiome and urethane-induced pulmonary adenocarcinoma.

Lung cancer is amongst the most common types of cancer throughout the world. The overall 5-year survival rate is ~17%. A number of studies have demonstrated that the microbiome existing within the host may affect the level of inflammation, and consequently contribute to the carcinogenesis of certain types of cancer.

Biometric recognition via texture features of eye movement trajectories in a visual searching task.

Biometric recognition technology based on eye-movement dynamics has been in development for more than ten years. Different visual tasks, feature extraction and feature recognition methods are proposed to improve the performance of eye movement biometric system. However, the correct identification and verification rates, especially in long-term experiments, as well as the effects of visual tasks and eye trackers' temporal and spatial resolution are still the foremost considerations in eye movement biometrics.

Neuroticism is associated with altered resting-state functional connectivity of amygdala following acute stress exposure.

The amygdala, a subcortical structure responsible for fear and vigilance, is central to the stress circuitry. Aberrant amygdala connectivity with the cortical and subcortical regions is found in patients with stress-related disorders, and in healthy subjects following acute stress exposure. However, the extent to which the stress-induced alteration of amygdala functional connectivity correlates with risk-related personality measures remains unclear.

Abnormal functional connectivity density in sleep-deprived subjects.

Sleep deprivation (SD) can alter the intrinsic brain functional organization. However, its effects on intrinsic low-frequency connectivity in the whole brain have not been well characterized. In this study, we used voxel-based functional connectivity density (FCD) analysis to investigate the effects of SD on the spontaneous functional organization of the brain.

White matter integrity correlates with residual consciousness in patients with severe brain injury.

Previous studies have suggested that white matter disruption plays an important role in disorders of consciousness (DOC) after severe brain injury. Nevertheless, the integrity of white matter architecture supporting consciousness and its relations with clinical severity in patients with DOC remain to be established. In this study, diffusion tensor imaging (DTI) data was collected from 14 DOC patients and 15 healthy control subjects.

Impact of 36 h of total sleep deprivation on resting-state dynamic functional connectivity.

Resting-state functional magnetic resonance imaging (fMRI) studies using static functional connectivity (sFC) measures have shown that the brain function is severely disrupted after long-term sleep deprivation (SD). However, increasing evidence has suggested that resting-state functional connectivity (FC) is dynamic and exhibits spontaneous fluctuation on a smaller timescale. The process by which long-term SD can influence dynamic functional connectivity (dFC) remains unclear.

Mirror-normal difference in the late phase of mental rotation: An ERP study.

Mirror-normal letter discriminations are thought to require mental rotation in order to transform the rotated alphanumeric character into its canonical orientation. Moreover, out-of-plane rotation is likely to occur after in-plane rotation to fully normalize the mirror version before the final mirror-normal judgment. The so-called rotation-related negativity, which varies with orientation, is found in both ERPonset (averaged with respect to stimulus onset) and ERPRT (averaged with respect to response time), representing the involvement of mental rotation in both time windows.

Uncovering the cognitive processes underlying mental rotation: an eye-movement study.

Mental rotation is an important paradigm for spatial ability. Mental-rotation tasks are assumed to involve five or three sequential cognitive-processing states, though this has not been demonstrated experimentally. Here, we investigated how processing states alternate during mental-rotation tasks.

Making group inferences using sparse representation of resting-state functional mRI data with application to sleep deprivation.

Past studies on drawing group inferences for functional magnetic resonance imaging (fMRI) data usually assume that a brain region is involved in only one functional brain network. However, recent evidence has demonstrated that some brain regions might simultaneously participate in multiple functional networks. Here, we presented a novel approach for making group inferences using sparse representation of resting-state fMRI data and its application to the identification of changes in functional networks in the brains of 37 healthy young adult participants after 36 h of sleep deprivation (SD) in contrast to the rested wakefulness (RW) stage.

Impact of aberrant cerebral perfusion on resting-state functional MRI: A preliminary investigation of Moyamoya disease.

The impact of chronic cerebral hypoperfusion on resting-state blood oxygen level-dependent signal fluctuations remains unknown. We aimed to determine whether chronic ischemia induces changes in amplitude of low-frequency fluctuations (ALFF) and to investigate the correlation between ALFF and perfusion-weighted magnetic resonance imaging (PWI) parameters in patients with moyamoya disease (MMD). Thirty patients with pre- and postoperative resting-state functional magnetic resonance imaging and PWI were included, and thirty normal controls underwent resting-state functional magnetic resonance imaging.