Mutational Profile and Retinal Phenotypes of -Related Cone-Rod Dystrophies in a Mexican Cohort.

Purpose: The aim of the study is to describe the genotype and phenotype of a Mexican cohort with -related retinal disease.

Methods: The study included 14 patients from 11 unrelated pedigrees with retinal dystrophies who were demonstrated to carry biallelic pathogenic variants in . Visual assessment methods included best corrected visual acuity, color fundus photography, Goldmann visual field test, kinetic perimetry, dark/light adapted chromatic perimetry, full-field electroretinography, autofluorescence imaging, and spectral domain-optical coherence tomography imaging.

Pupil dilation evaluation of two mydriatic dosing profiles delivered by the Optejet.

To compare pupil dilation achieved by a single microdose versus two microdoses of tropicamide-phenylephrine fixed combination (TR-PH FC) delivered by the Optejet. In this assessor-masked, crossover, noninferiority study, 60 volunteers underwent two treatment visits and received either one (∼8 μl) or two sprays (∼16 μl) of TR-PH FC to both eyes in randomly assigned order. At 35 min postdose, mean change in pupil diameter was 4.

MicroRNAs as potential biomarkers and therapeutic targets in age-related macular degeneration.

Age-related macular degeneration (AMD) involves degenerative and neovascular alteration in the macular region of the retina resulting in central vision loss. AMD can be classified into dry (dAMD) and wet AMD (wAMD). There is no established treatment for dAMD, and therapies available for wAMD have limited success.

Twelve-month clinical outcomes after implantation of a new, modular, anterior shape-changing fluid optic intraocular lens.

Purpose: To report the initial safety and effectiveness profile for an anterior shape-changing, modular IOL, Juvene IOL (JIOL), for the treatment of aphakia and presbyopia after removal of the natural crystalline lens due to cataract.

Setting: 2 private practices in Monterrey and Tijuana, Mexico.

Design: Exploratory prospective multicenter open-label noncomparative clinical trial.

Toward the Treatment of Inherited Diseases of the Retina Using CRISPR-Based Gene Editing.

Inherited retinal dystrophies [IRDs] are a common cause of severe vision loss resulting from pathogenic genetic variants. The eye is an attractive target organ for testing clinical translational approaches in inherited diseases. This has been demonstrated by the approval of the first gene supplementation therapy to treat an autosomal recessive IRD, RPE65-linked Leber congenital amaurosis (type 2), 4 years ago.

Eighty-micron flap femtosecond-assisted LASIK for the correction of myopia and myopic astigmatism.

Purpose: To evaluate the safety and efficacy of 80-μm flap femtosecond laser-assisted LASIK and the early clinical and refractive outcomes in the correction of myopia and myopic astigmatism.

Setting: Private practice, outpatient.

Design: Prospective study.

Implantation of Presbyopia-Correcting Intraocular Lenses Staged After Descemet Membrane Endothelial Keratoplasty in Patients With Fuchs Dystrophy.

Purpose: To assess outcomes of presbyopia-correcting intraocular lens (IOL) implantation after Descemet membrane endothelial keratoplasty (DMEK) in patients with Fuchs endothelial corneal dystrophy.

Methods: This retrospective single-center study evaluated a consecutive series of patients with Fuchs endothelial corneal dystrophy who received presbyopia-correcting IOLs after DMEK. The main outcomes were corrected distance visual acuity, uncorrected distance visual acuity, uncorrected near visual acuity, and refractive error.

Severe mycotic keratoconjunctivitis caused by sp. in an immunocompetent child successfully treated with intravenous voriconazole and keratoplasty: case report and short review of the literature.

Background: Pediatric mycotic infections in the eye are uncommon. However, ophthalmic infections by several fungal species have been described in immunocompetent subjects. Mycotic keratitis with or without conjunctivitis (MK) may account for more than 50% of all cases, particularly in tropical and sub-tropical areas.

Pharmacodynamic profile of mydriatic agents delivered by ocular piezo-ejection microdosing compared with conventional eyedropper.

Aim: Eyedroppers deliver medication volumes exceeding conjunctival absorptive capacity, causing spillage and risking ocular/systemic complications. We evaluated piezoelectric microdosing. Results/methodology: Subjects (n = 102) received precision microdroplet delivery of phenylephrine (2.

A nonrandomized, open-label study to evaluate the effect of nasal stimulation on tear production in subjects with dry eye disease.

Background: Dry eye disease (DED), a chronic disorder affecting the tear film and lacrimal functional unit, is a widely prevalent condition associated with significant burden and unmet treatment needs. Since specific neural circuits play an important role in maintaining ocular surface health, microelectrical stimulation of these pathways could present a promising new approach to treating DED. This study evaluated the efficacy and safety of nasal electrical stimulation in patients with DED.

Safety and efficacy of a hydrogel inlay with laser in situ keratomileusis to improve vision in myopic presbyopic patients: one-year results.

Purpose: To study the safety and efficacy of implanting a hydrogel corneal inlay (Raindrop Near Vision Inlay) concurrently with performing laser in situ keratomileusis (LASIK) to treat myopic presbyopia and to compare the results with results of the same treatment in emmetropic and hyperopic patients.

Setting: Two private clinics, Tijuana and Monterrey, Mexico.

Design: Prospective nonrandomized clinical trial.

[Deficient prevention and late treatment of diabetic retinopathy in Mexico].

Introduction: Retinopathy is a frequent complication of diabetes, causing visual impairment in 10% and blindness in 2% of diabetic patients. The aim of this study is to describe the clinical profile of diabetic patients in an ophthalmologic unit in Tijuana, México.

Methods: Retrospective study of a random sample of 500 clinical charts of patients with diabetes who attended the Retina Service of "Fundación CODET para la Prevención de la Ceguera IBP" Ophthalmologic Center between 2006 and 2010.

Intraocular polyimide intraocular lens haptic breakage long-term postoperatively.

Unlabelled: We present 2 cases of 3-piece silicone intraoculanbsp;r lenses (IOLs) with broken polyimide haptics. In the first case, the IOL was implanted in the anterior chamber after posterior capsule rupture. Twelve years later, it was explanted and exchanged because of bullous keratopathy.

Combined hydrogel inlay and laser in situ keratomileusis to compensate for presbyopia in hyperopic patients: one-year safety and efficacy.

Purpose: To perform a feasibility study of the safety and efficacy of a corneal-contouring inlay with concurrent laser in situ keratomileusis (LASIK) to treat hyperopic presbyopia.

Setting: Private clinic, Tijuana, Mexico.

Design: Prospective interventional case series.

Prospective, randomized, double-blind, contralateral eye comparison of myopic LASIK with optimized aspheric or prolate ablations.

Purpose: To compare the postoperative outcomes of aspheric or prolate LASIK for myopia and myopic astigmatism.

Methods: In this double-blind, bilateral, randomized trial, 40 patients (80 eyes) with -0.75 to -7.

Gabapentin for postoperative pain after photorefractive keratectomy: a prospective, randomized, double-blind, placebo-controlled trial.

Purpose: To determine whether treatment with oral gabapentin reduces postoperative pain after photorefractive keratectomy (PRK).

Methods: This prospective, randomized, double-blind, placebo-controlled study comprised 40 patients scheduled for bilateral PRK. Exclusion criteria were previous refractive surgery; diseases that could affect epithelial healing; use of antihistamines, nonsteroidal anti-inflammatory drugs, or steroids; and use of mitomycin C during PRK.

Correction of astigmatism after cataract surgery using the light adjustable lens: a 1-year follow-up pilot study.

Purpose: The management of preoperative and residual astigmatism is critical to obtain optimized uncorrected visual acuity. The aim of this study was to determine whether residual astigmatism could be precisely corrected postoperatively using the Light Adjustable Lens (LAL, Calhoun Vision Inc) and to determine the stability of the adjusted refraction.

Methods: Ten eyes of 10 patients with cataract and corneal astigmatism between 1.

Corneal endothelial safety after ultraviolet light treatment of the light-adjustable intraocular lens.

Purpose: To assess the safety to the corneal endothelium of ultraviolet (UV) light treatment to a light-adjustable intraocular lens (IOL).

Setting: Codet Vision Institute, Tijuana, Mexico.

Design: Cohort study.

Use of the light-adjustable lens to correct astigmatism after cataract surgery.

Aim: To determine if residual cylindrical refractive error after cataract surgery can be adjusted using the light-adjustable lens (LAL).

Methods: The LAL is a photosensitive silicone intraocular lens whose power can be adjusted post-operatively using UV light at 365 nm. A digital light delivery device (DLD) is used to adjust LAL power in situ to correct residual refractive errors non-invasively.

Correction of myopia after cataract surgery with a light-adjustable lens.

Purpose: To determine whether residual myopia could be corrected postoperatively using the light-adjustable lens (LAL) technology in patients undergoing cataract surgery and LAL implantation.

Design: A prospective clinical study was conducted at Codet Vision Institute in Tijuana, Mexico. The LALs were implanted that would purposely result in myopic errors of up to -1.

Correction of residual hyperopia after cataract surgery using the light adjustable intraocular lens technology.

Purpose: To determine whether residual hyperopia could be corrected postoperatively using the light adjustable lens technology in patients undergoing cataract surgery and light adjustable lens implantation.

Design: Prospective, nonrandomized clinical trial.

Methods: Fourteen eyes of 14 patients were studied.